DeepMed Research

Dydrogesterone

Generic Name: Dydrogesterone

Drug Type: Small Molecule

Chemical Formula: C_₂₁H_₂₈O_₂

CAS Number: 152-62-5

Unique Ingredient Identifier: 90I02KLE8K

Background: A synthetic progestational hormone with no androgenic or estrogenic properties. Unlike many other progestational compounds, dydrogesterone produces no increase in temperature and does not inhibit ovulation.

Indication: Used to treat irregular duration of cycles and irregular occurrence and duration of periods caused by progesterone deficiency. Also used to prevent natural abortion in patients who have a history of habitual abortions.

Associated Conditions: Infertility, Menstrual Distress (Dysmenorrhea), Premenstrual Syndrome (PMS), Recurrent Miscarriages, Spontaneous Abortions

Associated Therapies: Assisted Reproductive Technology therapy, Menstrual Regulation

Clinical Trials

Addition of Dydrogesterone to the Luteal Phase Support After Fresh Embryo Transfer

Not Applicable

Conditions: Infertility
IVF

Interventions: Drug: Dydrogesterone 10mg Oral Tablet

First Posted Date: 2020-05-29

Last Posted Date: 2021-10-04

Lead Sponsor: Laniado Hospital

Target Recruit Count: 300

Registration Number: NCT04408144

Locations: 🇮🇱
Laniado Hospital, Netanya, Israel

The Effect of Dydrogesterone on Sexual Function in Women With Endometriosis

Not Applicable

Completed

Conditions: Sexual Dysfunction
Endometriosis

Interventions: Drug: Dydrogesterone

First Posted Date: 2020-02-27

Last Posted Date: 2020-03-18

Lead Sponsor: Kanuni Sultan Suleyman Training and Research Hospital

Target Recruit Count: 79

Registration Number: NCT04287205

Locations: 🇹🇷
Pinar Yalcin Bahat, Istanbul, İ̇stanbul, Turkey

Predictors of Pregnancy Rate in Assisted Reproductive Technology According to Actual Guidelines

Conditions: Infertility

Interventions: Drug: Duphaston® (Dydrogesteron)

First Posted Date: 2020-01-30

Last Posted Date: 2021-12-28

Lead Sponsor: Abbott

Target Recruit Count: 1150

Registration Number: NCT04249297

Locations: 🇰🇿
PERSONA International Clinical Center for Reproductology, Almaty, Kazakhstan
🇷🇺
ART Department Irkutsk Regional Clinical Hospital, Irkutsk, Russian Federation
🇷🇺
Reproduction Clinic ' Philosophy of Life', Perm, Russian Federation

and more 45 locations

IVF Outcome Following Progestogen Ovarian Stimulation

Phase 1

Completed

Conditions: Clinical Pregnancy Rate
Oocyte Maturation Defect 1
Ovarian Hyperstimulation
IVF

Interventions: Drug: Dydrogesterone Pill

First Posted Date: 2019-11-25

Last Posted Date: 2019-11-26

Lead Sponsor: National University of Malaysia

Target Recruit Count: 155

Registration Number: NCT04175990

Locations: 🇲🇾
Medically Assisted Conception Unit, Ukm Medical Centre, Cheras, Kuala Lumpur, Malaysia

Oral Dydrogesterone vs. Micronized Vaginal Progesterone for Luteal Phase Support in Frozen-thawed Embryo Transfer Cycles

Phase 4

Conditions: Infertility, Female
Infertility, Male
Embryo Transfer
Fertilization in Vitro
Drug Effect
Reproductive Techniques, Assisted
Progesterone
Dydrogesterone

Interventions: Drug: Dydrogesterone 10 MG Oral Tablet
Drug: Progesterone Vaginal Gel [Crinone]

First Posted Date: 2019-10-14

Last Posted Date: 2019-10-14

Lead Sponsor: Memorial Sisli Hospital, Istanbul

Target Recruit Count: 140

Registration Number: NCT04124913

Locations: 🇹🇷
Memorial Şişli Hospital, Istanbul, Şişli, Turkey

Progesterone Versus Progesterone Plus Dydrogesterone in FET

Not Applicable

Completed

Conditions: Infertility

Interventions: Drug: Micronized progesterone plus dydrogesterone
Drug: Micronized Progesterone

First Posted Date: 2019-06-26

Last Posted Date: 2021-02-24

Lead Sponsor: Mỹ Đức Hospital

Target Recruit Count: 1364

Registration Number: NCT03998761

Locations: 🇻🇳
Mỹ Đức Hospital, Ho Chi Minh City, Tan Binh, Vietnam

Luteal Support in Frozen-Thawed Embryo Transfer Cycles

Phase 4

Completed

Conditions: Luteal Support
Assisted Reproduction
Implantation; Placenta
Pregnancy Loss
Frozen Embryo
Luteal Phase Defect

Interventions: Drug: Progesterone 50Mg/mL Oil
Drug: Crinone 8% Vaginal Gel
Drug: Dydrogesterone 10Mg Tablet (duphaston)

First Posted Date: 2019-05-13

Last Posted Date: 2022-01-11

Lead Sponsor: Centrum Clinic IVF Center

Target Recruit Count: 151

Registration Number: NCT03948022

Locations: 🇹🇷
Ufuk University School of Medicine, Ankara, Turkey

Oral Dydrogesterone in the Management of Preterm Labor

Phase 4

Completed

Conditions: Preterm Labor

Interventions: Drug: placebo
Drug: Dydrogesterone

First Posted Date: 2019-05-02

Last Posted Date: 2021-01-22

Lead Sponsor: Chulalongkorn University

Target Recruit Count: 48

Registration Number: NCT03935152

Locations: 🇹🇭
Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand

Oral Dydrogesterone as Luteal Phase Support in Natural Cycle FET

Phase 3

Recruiting

Conditions: Subfertility

Interventions: Drug: Placebo
Drug: Dydrogesterone

First Posted Date: 2019-03-01

Last Posted Date: 2024-05-09

Lead Sponsor: The University of Hong Kong

Target Recruit Count: 716

Registration Number: NCT03859921

Locations: 🇨🇳
Department of Obstetrics and Gynaecology, Hong Kong, Hong Kong, China

Efficacy and Safety of Crinone Versus Combination Medication (ACCESS)

Phase 4

Terminated

Conditions: Infertility

Interventions: Drug: Crinone
Drug: Duphaston

First Posted Date: 2019-02-28

Last Posted Date: 2024-03-12

Lead Sponsor: Merck KGaA, Darmstadt, Germany

Target Recruit Count: 172

Registration Number: NCT03858049

Locations: 🇨🇳
Peking University Third Hospital, Beijing, China

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