Overview
A metallic element found in certain minerals, in nearly all soils, and in mineral waters. It is an essential constituent of hemoglobin, cytochrome, and other components of respiratory enzyme systems. Its chief functions are in the transport of oxygen to tissue (hemoglobin) and in cellular oxidation mechanisms. Depletion of iron stores may result in iron-deficiency anemia. Iron is used to build up the blood in anemia.
Indication
Used in preventing and treating iron-deficiency anemia.
Associated Conditions
- Anemia
- Iron Deficiency (ID)
- Iron Deficiency Anemia (IDA)
- Restless Legs Syndrome (RLS)
- Concomitant myelosuppressive chemotherapy
Research Report
Iron (DB01592): A Comprehensive Monograph on its Pharmacology, Clinical Utility, and Safety Profile
Introduction to Iron: An Essential Element
Iron stands as a fundamental element not only in the Earth's crust but also within the intricate biological machinery of virtually all living organisms. Its unique chemical properties allow it to participate in a vast array of metabolic processes, making it indispensable for life. However, this same chemical reactivity renders it potentially toxic, necessitating a complex and tightly regulated system of absorption, transport, and storage within the body. This monograph provides a comprehensive examination of iron, identified by DrugBank ID DB01592, from its basic chemical profile to its complex pharmacology, diverse clinical applications, and extensive safety considerations. It synthesizes current knowledge to offer a detailed resource on iron's dual role as an essential nutrient and a critical therapeutic agent.
Chemical and Physical Profile
Elemental iron is a small molecule drug with the chemical symbol Fe.[1] It is unequivocally identified in scientific and regulatory databases by its Chemical Abstracts Service (CAS) Number 7439-89-6.[1] As a fundamental element, its molecular properties are defined by its atomic characteristics.
Clinical Trials
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Title | Posted | Study ID | Phase | Status | Sponsor |
---|---|---|---|---|---|
2024/09/19 | Not Applicable | Completed | Central Park Medical College | ||
2024/08/15 | Phase 4 | Completed | Centre Hospitalier Hassan II - Fès | ||
2024/07/23 | Phase 1 | Completed | |||
2024/07/22 | Phase 1 | Recruiting | |||
2024/07/18 | Phase 2 | Withdrawn | Mateusz Opyrchal | ||
2024/07/05 | Phase 2 | Not yet recruiting | The Second Hospital of Nanjing Medical University | ||
2024/06/20 | Phase 1 | Recruiting | |||
2024/05/31 | Not Applicable | Active, not recruiting | Akram Medical Complex | ||
2024/05/30 | Phase 3 | Not yet recruiting | |||
2024/05/23 | Phase 4 | Not yet recruiting |
FDA Drug Approvals
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Approved Product | Manufacturer | NDC Code | Route | Strength | Effective Date |
---|---|---|---|---|---|
Everett Laboratories, Inc. | 0642-0092 | ORAL | 27 mg in 1 1 | 4/18/2012 | |
MARTIN EKWEALOR PHARMACEUTICALS, INC. | 58607-112 | ORAL | 150 mg in 1 1 | 2/20/2014 | |
Everett Laboratories, Inc. | 0642-0070 | ORAL | 29 mg in 1 1 | 9/1/2021 | |
Nephro-Tech, Inc. | 59528-4456 | ORAL | 66 mg in 1 1 | 7/14/2021 | |
Acella Pharmaceuticals, LLC | 42192-343 | ORAL | 28 mg in 1 1 | 9/11/2018 | |
MISSION PHARMACAL COMPANY | 0178-0799 | ORAL | 28 mg in 1 1 | 6/3/2011 | |
Bryant Ranch Prepack | 63629-3545 | ORAL | 27 mg in 1 1 | 7/17/2014 | |
MISSION PHARMACAL COMPANY | 0178-0798 | ORAL | 30 mg in 1 1 | 1/18/2012 | |
CarWin Pharmaceutical Associates, LLC | 15370-250 | ORAL | 31 mg in 1 1 | 12/23/2019 | |
Everett Laboratories, Inc. | 0642-0120 | ORAL | 29 mg in 1 1 | 7/21/2014 |
EMA Drug Approvals
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NMPA Drug Approvals
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PPB Drug Approvals
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TGA Drug Approvals
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Health Canada Drug Approvals
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Approved Product | Company | DIN | Dosage Form | Strength | Market Date |
---|---|---|---|---|---|
LIPOTOX | bio active canada ltd. | 02233643 | Liquid - Oral | 12 X | 5/26/1998 |
FERRUM METALLICUM | seroyal international inc. | 02233134 | Tablet
,
Liquid
,
Drops
,
Pellet
,
Granules
,
Globules - Oral | 1 X | 4/6/1998 |
FERRUM SIDERIUM D8(D10 D12 D15 D20) DPS | weleda ag heilmittelbetriebe | 02088452 | Drops - Oral | 8 D / ML | 12/31/1995 |
FERO GRAD FILMTAB | ABBOTT LABORATORIES, LIMITED | 00038857 | Tablet (Extended-Release) - Oral | 105 MG | 12/31/1961 |
TRIOGENE FOR | produits francais labs inc. | 00166219 | Powder - Oral | 209.82 MG / 30 G | 12/31/1930 |
NUTRILITE DOUBLE X PACK | amway of canada, ltd. | 00763047 | Tablet - Oral | 3.3 MG / PCK | 12/31/1988 |
MULTIPLE VITAMINS AND MINERALS | d.c. labs limited | 01922572 | Tablet - Oral | 15 MG | 12/31/1976 |
MULTIVITAMINS W MINERALS EXTRA STRENGTH | watkins incorporated | 00240931 | Capsule - Oral | 18 MG | 12/31/1972 |
HOMEOPATHIC MEDICINE (S137) DPS 30C | total health centre | 02071525 | Drops - Oral | 30 C / ML | 12/31/1994 |
HEMAREXIN TAB | lab bio chimique inc.,division of technilab pharma inc. | 00514764 | Tablet - Oral | 5 MG | 12/17/1997 |
CIMA AEMPS Drug Approvals
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UK EMC Drug Information
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