Sodium citrate

Overview

Sodium citrate is the sodium salt of citric acid. It is white, crystalline powder or white, granular crystals, slightly deliquescent in moist air, freely soluble in water, practically insoluble in alcohol. Like citric acid, it has a sour taste. From the medical point of view, it is used as alkalinizing agent. It works by neutralizing excess acid in the blood and urine. It has been indicated for the treatment of metabolic acidosis.

Indication

Used as an anticoagulant during plasmophoresis as well as a neutralizing agent in the treatment of upset stomach and acidic urine .

Associated Conditions

Acidosis
Allergic Reaction
Allergic cough
Asthma
Asthma Chronic, Cough
Common Cold
Cough
Coughing caused by Bronchitis
Dehydration
Gout
Heartburn
Metabolic Acidosis
Phlegm

Clinical Trials

Title	Posted	Study ID	Phase	Status	Sponsor
The Impact of Nafamostat Mesylate on the Prognosis of Patients With Sepsis-Induced Coagulopathy Undergoing Hemofiltration	2025/05/29	NCT06994312	Not Applicable	Not yet recruiting	The First Hospital of Jilin University
Sodium Citrate in Smell Retraining for People With Post-COVID-19 Olfactory Dysfunction	2024/01/12	NCT06204432	Phase 2	Active, not recruiting	University of North Carolina, Chapel Hill
Comparison of Biocompatibility of Plasmapheresis Procedures With Citrate and Heparin Anticoagulation	2022/01/13	NCT05191290	Phase 4	Completed	University Medical Centre Ljubljana
A Study of Infusion Site Pain After Infusion of Excipients in Participants With Type 1 Diabetes Mellitus	2021/10/05	NCT05067270	Phase 1	Completed	Eli Lilly and Company
Pravastatin and Alkali Therapy in Patients With Autosomal Dominant Polycystic Kidney Disease	2020/02/26	NCT04284657	Phase 2	Completed	University of Southern California
Study Using Citrate to Replace Heparin in Babies Requiring Extracorporeal Membrane Oxygenation (ECMO)	2009/08/31	NCT00968565	Early Phase 1	Completed	Vanderbilt University
Study of the Relationship Between Calcium Levels and Intact Parathyroid Hormone (iPTH) in Adults With Repaired or Palliated Conotruncal Cardiac Defects	1999/10/19	NCT00004361	N/A	Completed	National Center for Research Resources (NCRR)

FDA Drug Approvals

Approved Product	Manufacturer	NDC Code	Route	Strength	Effective Date
ACD-A	Haemonetics Manufacturing Inc	53157-796	INTRAVENOUS	2.20 g in 100 mL	2/9/2015
Sodium Citrate and Citric Acid	Pharmaceutical Associates, Inc.	0121-0595	ORAL	500 mg in 5 mL	12/15/2022
STERILE CORD BLOOD COLLECTION UNIT (MSC123D)	Maco Productions	14498-005	INTRAVENOUS	0.92 g in 35 mL	8/14/2021
Sterile Cord Blood Collection Unit (MSC128D)	Maco Productions	14498-004	INTRAVENOUS	0.76 g in 29 mL	12/21/2017
TRICITRATES	PAI Holdings, LLC	0121-0677	ORAL	500 mg in 5 mL	4/10/2023
Leukotrap WB System	Haemonetics Corporation	53157-736	INTRAVENOUS	1.66 g in 63 mL	7/19/2023
Sodium Citrate and Citric Acid	Chartwell RX, LLC	62135-434	ORAL	500 mg in 5 mL	10/5/2023
Pall Sterile Cord Blood Collection Unit	Global Life Sciences Solutions USA LLC	79403-791	INTRAVENOUS	0.921 g in 35 mL	12/20/2023
TRICITRATES	ATLANTIC BIOLOGICALS CORP.	17856-0677	ORAL	500 mg in 5 mL	9/26/2018
Sodium Citrate	Haemonetics Manufacturing Inc	53157-798	INTRAVENOUS	10.0 g in 250 mL	2/9/2015

EMA Drug Approvals

Approved Product	Authorization Holder	Status	Issued Date
No EMA approvals found for this drug.

HSA Drug Approvals

Approved Product	Manufacturer	Approval Number	Dosage Form	Strength	Approval Date
HOVA EXPECTORANT	HOVID BHD	SIN03251P	SYRUP	57 mg/5 ml	6/12/1989
SEMERIN COUGH SYRUP	SUNWARD PHARMACEUTICAL PRIVATE LIMITED	SIN03526P	SYRUP	150 mg/5 ml	5/25/1989
REGIOCIT SOLUTION FOR HAEMOFILTRATION	Bieffe Medital S.p.A	SIN15513P	SOLUTION, STERILE	5.29 g/l	7/19/2018
MINICA S ENEMA	Yukinomoto Honten CO., LTD	SIN03514P	ENEMA	9% w/w	6/15/1989
SW BENA-EXPECTORANT	SUNWARD PHARMACEUTICAL PRIVATE LIMITED	SIN02911P	SYRUP	46 mg/5 ml	5/22/1989
SW-BENA PAEDIATRIC EXPECTORANT	SUNWARD PHARMACEUTICAL PRIVATE LIMITED	SIN07609P	SYRUP	50 mg/5 ml	1/14/1994
Ural Effervescent Granules	Aspen Pharma Pty Ltd	SIN14374P	GRANULE, EFFERVESCENT	0.63g	6/26/2013
XSP-BENA EXPECTORANT	XEPA-SOUL PATTINSON (MALAYSIA) SDN BHD	SIN03335P	SUSPENSION	57.5 mg/5 ml	6/16/1989

NMPA Drug Approvals

Approved Product	Company	Approval Number	Drug Type	Dosage Form	Approval Date
No NMPA approvals found for this drug.

PPB Drug Approvals

Approved Product	Registration No.	Company	Licence No.	Strength	Registration Date
DIPHENMIN EXPECTORANT	N/A	MARCHING PHARMACEUTICAL LIMITED	N/A	N/A	4/27/1979
U-BANOL "S" EXPECTORANT	N/A	synco (h.k.) limited	N/A	N/A	4/20/1979
GUSILON COUGH LINCTUS	N/A	karen laboratories o/b karen pharmaceutical co ltd	N/A	N/A	5/17/1982
NA-DRAMINE EXPECTORANT (BROWN)	N/A	NATIONAL PHARMACEUTICAL INDUSTRIES CO.	N/A	N/A	5/3/1979
MIST EXPECT STIM	N/A	MARCHING PHARMACEUTICAL LIMITED	N/A	N/A	2/25/1984
REGIOCIT SOLUTION FOR HAEMOFILTRATION	N/A	Vantive Healthcare Limited	N/A	N/A	8/11/2017
DIPHENHYDRAMINE COMPOUND LINCTUS	N/A	MARCHING PHARMACEUTICAL LIMITED	N/A	N/A	4/30/1998
CORY SYRUP	N/A	NEOCHEM PHARMACEUTICAL LABORATORIES LIMITED	N/A	N/A	4/27/1979
BANOLIN EXPECTORANT	N/A	AMERICAN UNICORN LABORATORIES LIMITED	N/A	N/A	1/7/1984
BENYL EXPECTORANT SYRUP	N/A	MARCHING PHARMACEUTICAL LIMITED	N/A	N/A	4/14/1987

TGA Drug Approvals

Approved Product	ARTG ID	Sponsor	Registration Type	Status	Registration Date
APOHEALTH Cystitis Relief oral powder sachet	227717	Arrotex Pharmaceuticals Pty Ltd	Medicine	A	9/8/2014
Chemists' Own Cystitis Relief effervescent granules sachet	297741	Arrotex Pharmaceuticals Pty Ltd	Medicine	A	12/19/2017
Gout Shield	445410	Aspen Pharmacare Australia Pty Ltd	Medicine	A	4/5/2024
URIZ URINARY ALKALINISER effervescent granules oral powder sachet	314267	Nova Pharmaceuticals Australasia Pty Ltd	Medicine	A	2/15/2019
PHARMACY HEALTH CYSTITIS RELIEF powder for oral liquid sachet	314974	NOUMED PHARMACEUTICALS PTY LTD	Medicine	A	3/1/2019
URACT CRANBERRY FLAVOUR EFFERVESCENT POWDER oral sachet	482087	Neo Health (OTC) Pty Ltd	Medicine	A	3/7/2025
AMCAL URICALM EFFERVESCENT CYSTITIS RELIEF powder for oral liquid sachet	479007	NOUMED PHARMACEUTICALS PTY LTD	Medicine	A	2/14/2025
GUARDIAN URICALM EFFERVESCENT CYSTITIS RELIEF powder for oral liquid sachet	479008	NOUMED PHARMACEUTICALS PTY LTD	Medicine	A	2/14/2025
Citrate Buffer 500 mL	477665	Baxter Healthcare Pty Ltd	Medicine	A	2/4/2025
AMCAL URICALM EFFERVESCENT granules oral powder sachet	210402	NOUMED PHARMACEUTICALS PTY LTD	Medicine	A	5/31/2013

Health Canada Drug Approvals

Approved Product	Company	DIN	Dosage Form	Strength	Market Date
MERCODOL WITH DECAPRYN	aventis pharma inc	02048183	Syrup - Oral	200 MG / 5 ML	12/31/1994
BALANCED SALT SOLUTION	pharma stulln inc.	02023709	Solution - Irrigation	1.7 MG / ML	12/31/1994
METRATE	medic laboratory ltée	00230200	Syrup - Oral	40 MG / 5 ML	12/31/1963
LEMON ENO 2650MG/PCK	smithkline beecham consumer healthcare, division of smithkline beecham inc.	02038234	Powder - Oral	2.65 G / PCK	12/31/1994
DALMACOL	laboratoire atlas inc	00507407	Syrup - Oral	200 MG / 5 ML	12/31/1983
BROMO SELTZER	warner-lambert canada inc.	00376469	Powder - Oral	3.5 G / 5.83 G	12/31/1976
ANTICOAGULANT SODIUM CITRATE SOLUTION USP	FENWAL INC	02344416	Solution - 0-Unassigned	4 G / 100 ML	11/1/2011
ANTICOAGULANT SOD CITRATE SOLTN 4GM/100ML	baxter corporation	00060313	Solution - 0-Unassigned	4 G / 100 ML	12/31/1990
ANTICOAGULANT SODIUM CITRATE SOLUTION, USP	fresenius kabi canada ltd	02529637	Solution - 0-Unassigned	4 G / 100 ML	10/31/2023
ANTICOAGULANT CITRATE DEXTROSE SOLUTION USP (ACD) FORMULA A	Fresenius Kabi AG	02516675	Solution - 0-Unassigned	2.14 G / 100 ML	N/A

CIMA AEMPS Drug Approvals

Approved Product	Company	Registration Number	Pharmaceutical Form	Prescription Type	Status
No CIMA AEMPS (Spain) approvals found for this drug.

Philippines FDA Drug Approvals

Approved Product	Company	License Number	Dosage Form	Strength	Approval Date
No Philippines FDA approvals found for this drug.

Saudi SFDA Drug Approvals

Approved Product	Company	License Number	Dosage Form	Strength	Approval Date
No Saudi SFDA approvals found for this drug.

Malaysia NPRA Drug Approvals

Approved Product	Company	Registration Number	Dosage Form	Strength	Approval Date
No Malaysia NPRA approvals found for this drug.

UK EMC Drug Information

Medicine Name	MA Holder	MA Number	Pharmaceutical Form	Active Ingredient	Authorization Date
No UK EMC drug information found for this drug.

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