Astemizole
未知生产厂商
Astemizole is a second generation antihistamine used to treat allergy symptoms.
Astemizole is a second generation antihistamine used to treat allergy symptoms.
Astemizole competes with histamine for binding at H-receptor sites in the GI tract, uterus, large blood vessels, and bronchial muscle. This reversible binding of astemizole to H-receptors suppresses the formation of edema, flare, and pruritus resulting from histaminic activity. As the drug does not readily cross the blood-brain barrier and preferentially binds at H1 receptors in the peripehery rather than within the brain, CNS depression is minimal. Astemizole may also act on H-receptors, producing adverse effects.
Astemizole was indicated for use in the relieving allergy symptoms, particularly rhinitis and conjunctivitis. It has been withdrawn from the market however due to concerns of arrhythmias.
每项发明一条，涵盖美国、欧洲、PCT 与中国的同族专利。
