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GC-373 is a peptide aldehyde which is metabolized from the bisulfide adduct, GC-376 free acid. It is an inhibitor of M (otherwise known as 3CL), a viral encoded protease that cleaves and activates functional proteins involved in viral replication and transcription. GC-373 has been shown to inhibit the M target in various coronavirus strains, including feline, mink, and ferret M . Along with its prodrug, GC-376, GC-373 was recently investigated in vitro in cell culture against SARS-Cov-2 M . The results showed potent inhibition of the target, suggesting that GC-373 holds therapeutic potential for Covid-19.
GC-373 is a peptide aldehyde which is metabolized from the bisulfide adduct, GC-376 free acid. It is an inhibitor of M (otherwise known as 3CL), a viral encoded protease that cleaves and activates functional proteins involved in viral replication and transcription. GC-373 has been shown to inhibit the M target in various coronavirus strains, including feline, mink, and ferret M . Along with its prodrug, GC-376, GC-373 was recently investigated in vitro in cell culture against SARS-Cov-2 M . The results showed potent inhibition of the target, suggesting that GC-373 holds therapeutic potential for Covid-19.
每项发明一条，涵盖美国、欧洲、PCT 与中国的同族专利。
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专利文献通常使用化学名或研发代号指代药物，而非通用名；且专利申请在提交约 18 个月后才公开，较新的药物可能尚未出现在这里。
