雷替曲塞 (Tomudex)

概览

Raltitrexed is a folate analog thymidylate synthase inhibitor used in the treatment of advanced colorectal cancer.

作用机制

Raltitrexed is an antineoplastic Agents and folic acid antagonists. Raltitrexed inhibits thymidylate synthase (TS) leading to DNA fragmentation and cell death. It is transported into cells via a reduced folate carrier. Inside the cell Raltitrexed is extensively polyglutamated, which enhances thymidylate synthase inhibitory power and duration. Inhibition of this enzyme results in decreased synthesis of thymidine triphosphate which is required for DNA synthesis.

适应症

For the treatment of malignant neoplasm of colon and rectum

• Advanced Colorectal Cancer
• Pleural Mesotheliomas