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10-1074-LS is a long-acting (LS) broadly neutralizing antibody against HIV-1. Together with 3BNC117-LS it was evaluated in the randomized, double-blind, placebo-controlled phase 2 RIO trial during analytical treatment interruption in adults who initiated antiretroviral therapy during primary or early HIV-1 infection; the bNAb combination significantly delayed viral rebound and prolonged ART-free control compared with placebo.
10-1074-LS is a long-acting (LS) broadly neutralizing antibody against HIV-1. Together with 3BNC117-LS it was evaluated in the randomized, double-blind, placebo-controlled phase 2 RIO trial during analytical treatment interruption in adults who initiated antiretroviral therapy during primary or early HIV-1 infection; the bNAb combination significantly delayed viral rebound and prolonged ART-free control compared with placebo.
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