Topiramate
- Generic Name
- Topiramate
- Brand Names
- Eprontia, Qsymia, Qudexy, Topamax, Trokendi
- Drug Type
- Small Molecule
- Chemical Formula
- C12H21NO8S
- CAS Number
- 97240-79-4
- Unique Ingredient Identifier
- 0H73WJJ391
- Background
Topiramate is a anti-epileptic drug used to manage seizures and prevent migraines. It was initially approved by the FDA in 1996. In 2004, topiramate was approved for the prevention of migraine in adults. Since 2012, the extended-release formulation has been approved in combination with phentermine for chronic weight management therapy in adults.
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- Indication
Topiramate is indicated for the following conditions: 1)Monotherapy for partial onset or primary generalized tonic-clonic seizures for patients 2 years of age and above 2)Adjunctive therapy for partial onset seizures or primary generalized tonic-clonic seizures for both adult and pediatric patients above 2 years old 3)Adjunctive therapy for seizures associat...
- Associated Conditions
- Alcohol Dependency, Epilepsy, Primary Generalized Tonic-Clonic Seizures, Generalized Tonic-Clonic Seizures, Lennox-Gastaut Syndrome, Migraine, Moods Disorders, Partial-Onset Seizures, Seizures, Weight
- Associated Therapies
- Chronic Weight Management therapy, Weight Reduction
Clinical Trial of Topiramate for Cocaine Addiction
- Conditions
- Interventions
- First Posted Date
- 2008-05-28
- Last Posted Date
- 2017-07-11
- Lead Sponsor
- Johns Hopkins University
- Target Recruit Count
- 250
- Registration Number
- NCT00685178
- Locations
- 🇺🇸
Behavioral Pharmacology Research Unit, Baltimore, Maryland, United States
Topiramate Treatment of Problem Drinkers
- First Posted Date
- 2008-02-29
- Last Posted Date
- 2018-03-08
- Lead Sponsor
- UConn Health
- Target Recruit Count
- 200
- Registration Number
- NCT00626925
- Locations
- 🇺🇸
University of Pennsylvania, Philadelphia, Pennsylvania, United States
Preventing Epilepsy After Traumatic Brain Injury With Topiramate
- Conditions
- Interventions
- First Posted Date
- 2008-01-23
- Last Posted Date
- 2017-06-27
- Lead Sponsor
- University of Pennsylvania
- Target Recruit Count
- 6
- Registration Number
- NCT00598923
Adjunctive Topiramate for Treatment of Alcohol Dependence in Patients With Bipolar Disorder
- First Posted Date
- 2007-12-12
- Last Posted Date
- 2017-01-09
- Lead Sponsor
- Stanford University
- Target Recruit Count
- 12
- Registration Number
- NCT00572117
- Locations
- 🇺🇸
Stanford/VA Palo Alto Mood Disorder Research Program, Palo Alto, California, United States
The Use of Anticonvulsants for Treatment of Patients With Alcohol Dependence and Post Traumatic Stress Disorder
- Conditions
- Interventions
- First Posted Date
- 2007-12-11
- Last Posted Date
- 2020-11-16
- Lead Sponsor
- Yale University
- Registration Number
- NCT00571246
- Locations
- 🇺🇸
VA Connecticut Healthcare System, West Haven, Connecticut, United States
Carisbamate Retention Study (CaReS): Comparative Study on the Long Term Effectiveness, Safety and Tolerability of Carisbamate Compared to Two Other Frequently Prescribed Anti-epileptic Drugs (AEDs) in Patients With Epilepsy.
- Conditions
- Interventions
- First Posted Date
- 2007-11-26
- Last Posted Date
- 2013-01-29
- Lead Sponsor
- SK Life Science, Inc.
- Target Recruit Count
- 89
- Registration Number
- NCT00563459
A Study Comparing Multiple Doses of VI-0521 With Placebo and Their Single-agent Constituents for Treatment of Obesity in Adults
- First Posted Date
- 2007-11-26
- Last Posted Date
- 2015-03-30
- Lead Sponsor
- VIVUS LLC
- Target Recruit Count
- 756
- Registration Number
- NCT00563368
- Locations
- 🇺🇸
Research Site, Philadelphia, Pennsylvania, United States
Pharmacokinetic Comparison of Multiple Formulations of Topiramate and Phentermine in Obese Adults
- First Posted Date
- 2007-08-20
- Last Posted Date
- 2011-06-08
- Lead Sponsor
- VIVUS LLC
- Target Recruit Count
- 64
- Registration Number
- NCT00518466
- Locations
- 🇺🇸
VIVUS, Inc., Mountain View, California, United States
Topiramate for Treatment of Patients With Borderline Personality Disorder and Alcohol Dependence
- Conditions
- First Posted Date
- 2007-04-20
- Last Posted Date
- 2012-01-31
- Lead Sponsor
- Elizabeth Ralevski
- Registration Number
- NCT00463775
Detoxification and Treatment of Subjects With Medication Overuse Headache
- Conditions
- First Posted Date
- 2007-02-08
- Last Posted Date
- 2007-02-08
- Lead Sponsor
- The New England Center for Headache, P.C.
- Target Recruit Count
- 60
- Registration Number
- NCT00432549
- Locations
- 🇺🇸
The New England Center for Headache, P.C., Stamford, Connecticut, United States
Drug Development Updates
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