Topiramate
- Generic Name
- Topiramate
- Brand Names
- Eprontia, Qsymia, Qudexy, Topamax, Trokendi
- Drug Type
- Small Molecule
- Chemical Formula
- C12H21NO8S
- CAS Number
- 97240-79-4
- Unique Ingredient Identifier
- 0H73WJJ391
- Background
Topiramate is a anti-epileptic drug used to manage seizures and prevent migraines. It was initially approved by the FDA in 1996. In 2004, topiramate was approved for the prevention of migraine in adults. Since 2012, the extended-release formulation has been approved in combination with phentermine for chronic weight management therapy in adults.
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- Indication
Topiramate is indicated for the following conditions: 1)Monotherapy for partial onset or primary generalized tonic-clonic seizures for patients 2 years of age and above 2)Adjunctive therapy for partial onset seizures or primary generalized tonic-clonic seizures for both adult and pediatric patients above 2 years old 3)Adjunctive therapy for seizures associat...
- Associated Conditions
- Alcohol Dependency, Epilepsy, Primary Generalized Tonic-Clonic Seizures, Generalized Tonic-Clonic Seizures, Lennox-Gastaut Syndrome, Migraine, Moods Disorders, Partial-Onset Seizures, Seizures, Weight
- Associated Therapies
- Chronic Weight Management therapy, Weight Reduction
Topiramate vs. Placebo in Preventing Weight Gain in Bipolar Disorder Treated With Olanzapine
- First Posted Date
- 2006-10-31
- Last Posted Date
- 2013-04-04
- Lead Sponsor
- University of Cincinnati
- Target Recruit Count
- 31
- Registration Number
- NCT00394095
- Locations
- 🇺🇸
University of Cincinnati Medical Center, Cincinnati, Ohio, United States
Topiramate on Gambling-Related Behaviours
- Conditions
- First Posted Date
- 2006-08-30
- Last Posted Date
- 2015-07-22
- Lead Sponsor
- Centre for Addiction and Mental Health
- Registration Number
- NCT00370188
- Locations
- 🇨🇦
Centre for Addiction and Mental Health, Toronto, Ontario, Canada
Topiramate for the Treatment of Methamphetamine Dependence - 1
- First Posted Date
- 2006-06-28
- Last Posted Date
- 2017-03-27
- Lead Sponsor
- National Institute on Drug Abuse (NIDA)
- Target Recruit Count
- 140
- Registration Number
- NCT00345371
- Locations
- 🇺🇸
Matrix Institute on Addictions, Costa Mesa, California, United States
🇺🇸John A. Burns School of Medicine, Honolulu, Hawaii, United States
🇺🇸University of Missouri - Kansas City, Kansas City, Missouri, United States
An Efficacy and Tolerability Study for Topiramate in Obese Patients With Binge Eating Disorder.
- Conditions
- First Posted Date
- 2006-03-28
- Last Posted Date
- 2011-01-31
- Lead Sponsor
- Janssen-Cilag Farmaceutica Ltda.
- Target Recruit Count
- 73
- Registration Number
- NCT00307619
Topiramate for the Treatment of Alcohol Dependent Binge-Eating Disordered Individuals
- First Posted Date
- 2006-03-09
- Last Posted Date
- 2017-07-12
- Lead Sponsor
- University of Virginia
- Target Recruit Count
- 5
- Registration Number
- NCT00300742
- Locations
- 🇺🇸
UVA CARE, Charlottesville, Virginia, United States
🇺🇸UVA CARE Richmond, Richmond, Virginia, United States
An Observational Study Evaluating the Safety of Topiramate for the Prevention of Migraine
- First Posted Date
- 2006-02-28
- Last Posted Date
- 2010-04-27
- Lead Sponsor
- Janssen Cilag Pharmaceutica S.A.C.I., Greece
- Target Recruit Count
- 80
- Registration Number
- NCT00297336
A Study of the Safety of Topiramate Given in Combination With Other Medications in Adults and Children With Seizures
- First Posted Date
- 2006-02-28
- Last Posted Date
- 2010-04-27
- Lead Sponsor
- Janssen Cilag Pharmaceutica S.A.C.I., Greece
- Target Recruit Count
- 153
- Registration Number
- NCT00297349
An Observational Study of the Safety of Topiramate in Adults and Children With Epilepsy
- First Posted Date
- 2006-02-28
- Last Posted Date
- 2010-04-27
- Lead Sponsor
- Janssen Cilag Pharmaceutica S.A.C.I., Greece
- Target Recruit Count
- 80
- Registration Number
- NCT00297323
Does Topiramate Adjust the Excitability of the Brain in Migraine Sufferers?
- Conditions
- First Posted Date
- 2006-02-06
- Last Posted Date
- 2006-02-14
- Lead Sponsor
- Emerald City Headache Organization
- Target Recruit Count
- 10
- Registration Number
- NCT00286923
- Locations
- 🇺🇸
Swedish Headache Clinic, Seattle, Washington, United States
Topiramate for the Prophylactic Treatment of Cyclic Vomiting Syndrome in Children
- Conditions
- First Posted Date
- 2006-02-06
- Last Posted Date
- 2011-01-06
- Lead Sponsor
- Monarch Medical Research
- Target Recruit Count
- 12
- Registration Number
- NCT00286988
- Locations
- 🇺🇸
Monarch Medical Research - Child and Adolescent Neurology, Norfolk, Virginia, United States
Drug Development Updates
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