Topiramate
- Generic Name
- Topiramate
- Brand Names
- Eprontia, Qsymia, Qudexy, Topamax, Trokendi
- Drug Type
- Small Molecule
- Chemical Formula
- C12H21NO8S
- CAS Number
- 97240-79-4
- Unique Ingredient Identifier
- 0H73WJJ391
- Background
Topiramate is a anti-epileptic drug used to manage seizures and prevent migraines. It was initially approved by the FDA in 1996. In 2004, topiramate was approved for the prevention of migraine in adults. Since 2012, the extended-release formulation has been approved in combination with phentermine for chronic weight management therapy in adults.
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- Indication
Topiramate is indicated for the following conditions: 1)Monotherapy for partial onset or primary generalized tonic-clonic seizures for patients 2 years of age and above 2)Adjunctive therapy for partial onset seizures or primary generalized tonic-clonic seizures for both adult and pediatric patients above 2 years old 3)Adjunctive therapy for seizures associat...
- Associated Conditions
- Alcohol Dependency, Epilepsy, Primary Generalized Tonic-Clonic Seizures, Generalized Tonic-Clonic Seizures, Lennox-Gastaut Syndrome, Migraine, Moods Disorders, Partial-Onset Seizures, Seizures, Weight
- Associated Therapies
- Chronic Weight Management therapy, Weight Reduction
Efficacy of Adding Topiramate to Current Treatment in Refractory Obsessive Compulsive Disorder (OCD)
- First Posted Date
- 2005-09-16
- Last Posted Date
- 2020-09-01
- Lead Sponsor
- McMaster University
- Target Recruit Count
- 23
- Registration Number
- NCT00182520
- Locations
- 🇨🇦
MacAnxiety Research Centre, Hamilton, Ontario, Canada
Topiramate for Alcohol and Cocaine Dependence
- First Posted Date
- 2005-09-14
- Last Posted Date
- 2020-07-07
- Lead Sponsor
- Kyle Kampman
- Target Recruit Count
- 170
- Registration Number
- NCT00167245
- Locations
- 🇺🇸
University of Pennsylvania, Treatment Research Center, Philadelphia, Pennsylvania, United States
A Multicenter Comparative Trial of Zonisamide and Topiramate as Initial Monotherapy in Untreated Epilepsies
- First Posted Date
- 2005-09-12
- Last Posted Date
- 2009-09-02
- Lead Sponsor
- Eisai Korea Inc.
- Target Recruit Count
- 140
- Registration Number
- NCT00154076
- Locations
- 🇰🇷
Daegu Catholic University Medical Center, Daegu, Korea, Republic of
A Study of Topiramate in Pediatric Subjects With Basilar/Hemiplegic Migraine
- Conditions
- First Posted Date
- 2005-09-12
- Last Posted Date
- 2007-04-05
- Lead Sponsor
- Monarch Medical Research
- Target Recruit Count
- 40
- Registration Number
- NCT00158002
- Locations
- 🇺🇸
Monarch Medical Research - Child and Adolescent Neurology, Norfolk, Virginia, United States
Relationship Between Topiramate Use and Ocular Angle Status
- Conditions
- First Posted Date
- 2005-09-12
- Last Posted Date
- 2007-10-31
- Lead Sponsor
- Chinese University of Hong Kong
- Target Recruit Count
- 15
- Registration Number
- NCT00153699
- Locations
- 🇭🇰
Hong Kong Eye Hospital, Kowloon, Hong Kong
🇭🇰Prince of Wales Hospital, Shatin, Hong Kong
Dose Comparison Study of Topiramate in Pediatric Subjects With Basilar/Hemiplegic Migraine
- Conditions
- First Posted Date
- 2005-08-18
- Last Posted Date
- 2012-11-12
- Lead Sponsor
- Monarch Medical Research
- Target Recruit Count
- 40
- Registration Number
- NCT00131443
- Locations
- 🇺🇸
Monarch Medical Research - Child and Adolescent Neurology, Norfolk, Virginia, United States
Topiramate as Adjunctive Therapy in Infants 1-24 Months for the Control of Partial Onset Seizures
- Conditions
- Interventions
- First Posted Date
- 2005-06-13
- Last Posted Date
- 2014-03-26
- Target Recruit Count
- 118
- Registration Number
- NCT00113815
Treatment of Self-Injurious Behavior in Individuals With Prader-Willi Syndrome
- Conditions
- First Posted Date
- 2003-08-05
- Last Posted Date
- 2013-05-01
- Target Recruit Count
- 10
- Registration Number
- NCT00065923
- Locations
- 🇺🇸
University of Florida-Brain Institute, Gainesville, Florida, United States
A Study on the Safety and Efficacy of Topiramate in the Treatment of Patients With Bipolar I Disorder
- Conditions
- First Posted Date
- 2002-05-21
- Last Posted Date
- 2011-05-18
- Target Recruit Count
- 434
- Registration Number
- NCT00037674
A Study to Evaluate the Safety and Effectiveness of Topiramate Compared to Placebo in the Treatment of Patients With Bipolar I Disorder
- Conditions
- Interventions
- First Posted Date
- 2002-05-07
- Last Posted Date
- 2011-06-27
- Target Recruit Count
- 13
- Registration Number
- NCT00035802
Drug Development Updates
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