Overview
Helium is a second most abundant chemical element in the universe with symbol He and atomic number 2. It is a colorless, odorless, tasteless, non-toxic, inert, monatomic gas located at the top of the noble gases on the periodic table. Its boiling and melting points are the lowest among all the elements. Its clinical benefit in inhalation therapy arises from its advantageous physical properties than ambient air. Helium has lower density than air and generates less resistance than to provide improved lung ventilation. It is also used as an analytical reagent in diagnostic/imaging tests to detect respiratory function of the patient.
Indication
For use in patients who are not getting enough oxygen into their blood due to blockages in the lungs from pathological conditions or injuries. Suggested potential benefit in upper airway obstruction, in severe asthma, and in exacerbations of COPD/COLD. Helium may be used in place of carbon monoxide during laparoscopic surgeries as it lowers the risk of developing respiratory acidosis in selected patients.
Associated Conditions
- Increased upper airway resistance
- Upper Airway Obstruction
Clinical Trials
Title | Posted | Study ID | Phase | Status | Sponsor |
|---|---|---|---|---|---|
2006/10/31 | Not Applicable | Completed |
FDA Drug Approvals
Approved Product | Manufacturer | NDC Code | Route | Strength | Effective Date |
|---|---|---|---|---|---|
| Airgas Intermountain Inc | 58420-004 | RESPIRATORY (INHALATION) | 992 mL in 1 L | 6/22/2010 | |
| Machine & Welding Supply Company dba Arc3 Gases South | 49575-020 | RESPIRATORY (INHALATION) | 990 mL in 1 L | 12/8/2023 | |
| Aero All Gas Company | 10014-004 | RESPIRATORY (INHALATION) | 990 mL in 1 L | 10/17/2023 | |
| Encompass Medical & Specialty Gases, Ltd. | 48883-006 | RESPIRATORY (INHALATION) | 990 mL in 1 L | 12/6/2010 | |
| Praxair Distribution, Inc. | 59579-009 | RESPIRATORY (INHALATION) | 800 mL in 1 L | 1/19/2023 | |
| Airgas Northern California and Nevada, Inc. | 58789-005 | RESPIRATORY (INHALATION) | 999 mL in 1 L | 5/20/2010 | |
| Airgas Usa, LLC | 11054-032 | RESPIRATORY (INHALATION) | 700 mL in 1 L | 7/12/2018 | |
| Aero All Gas Company | 10014-006 | RESPIRATORY (INHALATION) | 800 mL in 1 L | 5/25/2010 | |
| Airgas Intermountain Inc | 58420-007 | RESPIRATORY (INHALATION) | 800 mL in 1 L | 6/22/2010 | |
| Airgas-West, Inc. | 10678-007 | RESPIRATORY (INHALATION) | 600 mL in 1 L | 4/30/2010 |
EMA Drug Approvals
Approved Product | Authorization Holder | Status | Issued Date |
|---|---|---|---|
| No EMA approvals found for this drug. | |||
HSA Drug Approvals
Approved Product | Manufacturer | Approval Number | Dosage Form | Strength | Approval Date |
|---|---|---|---|---|---|
| No HSA approvals found for this drug. | |||||
NMPA Drug Approvals
Approved Product | Company | Approval Number | Drug Type | Dosage Form | Approval Date |
|---|---|---|---|---|---|
| No NMPA approvals found for this drug. | |||||
PPB Drug Approvals
Approved Product | Registration No. | Company | Licence No. | Strength | Registration Date |
|---|---|---|---|---|---|
| No PPB approvals found for this drug. | |||||
TGA Drug Approvals
Approved Product | ARTG ID | Sponsor | Registration Type | Status | Registration Date |
|---|---|---|---|---|---|
| HELIOX 28 oxygen/helium 28/72% v/v medical gas mixture | 90662 | Medicine | A | 8/21/2003 | |
| MEDICAL MIXTURE, OXYGEN/HELIUM | 34473 | Medicine | A | 1/2/1992 | |
| HELIUM, MEDICAL GRADE | 34467 | Medicine | A | 1/2/1992 | |
| MEDICAL SPECIAL GAS MIXTURES | 34465 | Medicine | A | 1/2/1992 |
Health Canada Drug Approvals
Approved Product | Company | DIN | Dosage Form | Strength | Market Date |
|---|---|---|---|---|---|
| HELIUM USP | 02014475 | Gas - Inhalation | 99 % / V/V | 12/31/1993 | |
| LUNG DIFFUSION TEST MIXTURE | matheson gas products canada inc. | 00580759 | Gas - Inhalation | 15 % | 12/31/1982 |
| HELIUM / OXYGEN MIXTURE | 02154846 | Gas - Inhalation | 50 % / V/V | 12/31/1995 | |
| LUNG DIFFUSION TEST MIX NOHCO | liquid carbonic inc. | 00588067 | Gas - Inhalation | 10 % | 12/31/1968 |
| HELIUM 100% | Air Liquide Canada Inc. | 00572888 | Gas - Inhalation | 100 % | 12/31/1911 |
| HELIUM-OXYGEN MIX GAS | Praxair Canada Inc | 01906801 | Gas - Inhalation | 50 % | 12/30/1970 |
| OXYGEN IN HELIUM MIX | matheson gas products canada inc. | 00588105 | Gas - Inhalation | 70 % | 12/31/1983 |
| HELIUM 100% | matheson gas products canada inc. | 00581186 | Gas - Inhalation | 100 % | 12/31/1983 |
| CO-HE-O2-N2 MIXTURE | 02154773 | Gas - Inhalation | 10.0 % | 12/31/1995 | |
| HELIUM OXYGEN MIXTURE | Air Liquide Canada Inc. | 00572896 | Gas - Inhalation | 80 % | 12/31/1911 |
CIMA AEMPS Drug Approvals
Approved Product | Company | Registration Number | Pharmaceutical Form | Prescription Type | Status |
|---|---|---|---|---|---|
| No CIMA AEMPS (Spain) approvals found for this drug. | |||||
Philippines FDA Drug Approvals
Approved Product | Company | License Number | Dosage Form | Strength | Approval Date |
|---|---|---|---|---|---|
| No Philippines FDA approvals found for this drug. | |||||
Saudi SFDA Drug Approvals
Approved Product | Company | License Number | Dosage Form | Strength | Approval Date |
|---|---|---|---|---|---|
| No Saudi SFDA approvals found for this drug. | |||||
Malaysia NPRA Drug Approvals
Approved Product | Company | Registration Number | Dosage Form | Strength | Approval Date |
|---|---|---|---|---|---|
| No Malaysia NPRA approvals found for this drug. | |||||
UK EMC Drug Information
Medicine Name | MA Holder | MA Number | Pharmaceutical Form | Active Ingredient | Authorization Date |
|---|---|---|---|---|---|
| No UK EMC drug information found for this drug. | |||||
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