Procaine benzylpenicillin
- Generic Name
- Procaine benzylpenicillin
- Brand Names
- Bicillin
- Drug Type
- Small Molecule
- Chemical Formula
- C29H38N4O6S
- CAS Number
- 54-35-3
- Unique Ingredient Identifier
- 1LW5K9CIR1
Overview
Procaine benzylpenicillin (INN), also known as procaine G penicillin, is an injectable antiobiotic. It is a poorly soluble salt form of penicillin which is a combination of naturally occuring benzylpenicillin (penicillin G) and the local anaesthetic agent procaine in equimolar amounts. Procaine benzylpenicillin is administered by deep intramuscular injection. It is slowly absorbed and hydrolyzed to benzylpenicillin. This drug is used where prolonged exposure to benzylpenicillin at a low concentration is required. This combination is aimed at reducing the pain and discomfort associated with a large intramuscular injection of penicillin. It is widely used in veterinary settings. Benzylpenicillin is active against a wide range of organisms and is the drug of first choice for many infections.
Background
Procaine benzylpenicillin (INN), also known as procaine G penicillin, is an injectable antiobiotic. It is a poorly soluble salt form of penicillin which is a combination of naturally occuring benzylpenicillin (penicillin G) and the local anaesthetic agent procaine in equimolar amounts. Procaine benzylpenicillin is administered by deep intramuscular injection. It is slowly absorbed and hydrolyzed to benzylpenicillin. This drug is used where prolonged exposure to benzylpenicillin at a low concentration is required. This combination is aimed at reducing the pain and discomfort associated with a large intramuscular injection of penicillin. It is widely used in veterinary settings. Benzylpenicillin is active against a wide range of organisms and is the drug of first choice for many infections.
Indication
For the treatment of a number of bacterial infections such as syphilis, anthrax, mouth infections, pneumonia and diphtheria.
Associated Conditions
- Anthrax
- Bacterial Infections
- Diphtheria
- Endocarditis, Subacute Bacterial
- Erysipelas
- Erysipelas caused by susceptible streptococci
- Erysipeloid
- Necrotizing ulcerative gingivostomatitis
- Non-venereal endemic syphilis
- Otitis Media caused by susceptible pneumococci
- Pinta
- Pneumonia caused by susceptible pneumococci
- Primary Syphilis
- Respiratory Tract Infections (RTI)
- Scarlet Fever
- Scarlet Fever caused by susceptible streptococci
- Secondary Syphilis
- Skin Structures and Soft Tissue Infections caused by susceptible streptococci
- Skin and Subcutaneous Tissue Bacterial Infections
- Tertiary syphilis
- Upper Respiratory Tract Infection caused by susceptible streptococci
- Yaws
- Rat bite fever
Clinical Trials
Title | Posted | Study ID | Phase | Status | Sponsor |
|---|
No clinical trials found
No clinical trials found for this drug
FDA Approved Products
Product Name | Manufacturer | Route | Strength | Approved | NDC Code |
|---|---|---|---|---|---|
BICILLIN CR | Pfizer Laboratories Div Pfizer Inc | INTRAMUSCULAR | 600000 [iU] in 2 mL | 2023/09/12 | 60793-601 |
BICILLIN C-R 900/300 | Pfizer Laboratories Div Pfizer Inc | INTRAMUSCULAR | 300000 [iU] in 2 mL | 2023/09/12 | 60793-602 |
BICILLIN CR | Pfizer Laboratories Div Pfizer Inc | INTRAMUSCULAR | 600000 [iU] in 2 mL | 2023/09/12 | 60793-600 |
BICILLIN CR | Dispensing Solutions, Inc. | INTRAMUSCULAR | 600000 [iU] in 2 mL | 2013/10/29 | 68258-8910 |
EMA Approved Products
Medicine Name | EMA Number | Auth. Holder | Country | Drug Type | Status | Issued | Opinion | Revision |
|---|
No EMA products found
No EMA products found for this drug
Singapore Approved Products
Product Name | Manufacturer | Dosage Form | Strength | Approved | Approval No. | Online |
|---|
No Singapore products found
No Singapore products found for this drug
China Approved Products
Product Name | Approval No. | Manufacturer | Dosage Form | Trade Name | Strength | Type | Status | Date | Import |
|---|---|---|---|---|---|---|---|---|---|
Procaine Benzylpenicillin for Injection | 国药准字H31020690 | 上海新先锋药业有限公司 | 注射剂 | N/A | 400万单位(普鲁卡因青霉素300万单位及青霉素钠(钾)100万单位) | Chemical Drug | Approved | 2002/09/13 | Domestic |
Procaine Benzyl penicillin for Injection | 国药准字H20033317 | 瑞阳制药股份有限公司 | 注射剂(无菌分装粉针剂) | N/A | 80万单位[普鲁卡因青霉素60万单位、青霉素钠(钾)20万单位] | Chemical Drug | Approved | 2020/03/25 | Domestic |
Procaine Benzylpenicillin for Injection | 国药准字H36020250 | 江西东风药业股份有限公司 | 注射剂 | N/A | 80万单位[普鲁卡因青霉素60万单位,青霉素钠(钾)20万单位] | Chemical Drug | Approved | 2021/07/14 | Domestic |
Procaine Benzyl Penicillin for Injection | 国药准字H35020355 | 郑州豫港之星制药有限公司 | 注射剂 | N/A | 40万单位[普鲁卡因青霉素30万单位, 青霉素钠(钾)10万单位] | Chemical Drug | Approved | 2019/08/14 | Domestic |
Procaine Benzylpenicillin for Injection | 国药准字H20023079 | 天津南华制药有限公司 | 粉针剂 | N/A | 40万单位 | Chemical Drug | Approved | 2002/02/20 | Domestic |
Procaine Benzyl penicillin for Injection | 国药准字H20003037 | 华北制药股份有限公司 | 注射剂 | N/A | 100万单位 | Chemical Drug | Approved | 2020/04/13 | Domestic |
Procaine Benzylpenicillin for Injection | 国药准字H51023281 | 成都第一制药有限公司 | 注射剂(注射用无菌粉末) | N/A | 40万单位(普鲁卡因30万单位,青霉素钠(钾)10万单位) | Chemical Drug | Approved | 2021/06/23 | Domestic |
Procaine Benzyl penicillin for Injection | 国药准字H20033316 | 瑞阳制药股份有限公司 | 注射剂(无菌分装粉针剂) | N/A | 40万单位[普鲁卡因青霉素30万单位、青霉素钠(钾)10万单位] | Chemical Drug | Approved | 2020/03/25 | Domestic |
Procaine Benzylpenicillin for Injection | 国药准字H31020951 | 上海新先锋药业有限公司 | 注射剂 | N/A | 40万单位(普鲁卡因青霉素30万单位及青霉素钠(钾)10万单位) | Chemical Drug | Approved | 2002/09/13 | Domestic |
Procaine Benzylpenicillin for Injection | 国药准字H31021036 | 上海新先锋药业有限公司 | 注射剂 | N/A | 200万单位(普鲁卡因青霉素150万单位及青霉素钠(钾)50万单位) | Chemical Drug | Approved | 2002/09/13 | Domestic |
Australia Approved Products
Product Name | ARTG ID | Sponsor | Status | Reg. Date | Ingredient |
|---|---|---|---|---|---|
CILICAINE SYRINGE 1.5 procaine benzylpenicillin (procaine penicillin) 1.5g injection syringe | 288818 | Viatris Pty Ltd | Active | 2017/08/04 | procaine benzylpenicillin |