Overview
Procaine benzylpenicillin (INN), also known as procaine G penicillin, is an injectable antiobiotic. It is a poorly soluble salt form of penicillin which is a combination of naturally occuring benzylpenicillin (penicillin G) and the local anaesthetic agent procaine in equimolar amounts. Procaine benzylpenicillin is administered by deep intramuscular injection. It is slowly absorbed and hydrolyzed to benzylpenicillin. This drug is used where prolonged exposure to benzylpenicillin at a low concentration is required. This combination is aimed at reducing the pain and discomfort associated with a large intramuscular injection of penicillin. It is widely used in veterinary settings. Benzylpenicillin is active against a wide range of organisms and is the drug of first choice for many infections.
Indication
For the treatment of a number of bacterial infections such as syphilis, anthrax, mouth infections, pneumonia and diphtheria.
Associated Conditions
- Anthrax
- Bacterial Infections
- Diphtheria
- Endocarditis, Subacute Bacterial
- Erysipelas
- Erysipelas caused by susceptible streptococci
- Erysipeloid
- Necrotizing ulcerative gingivostomatitis
- Non-venereal endemic syphilis
- Otitis Media caused by susceptible pneumococci
- Pinta
- Pneumonia caused by susceptible pneumococci
- Primary Syphilis
- Respiratory Tract Infections (RTI)
- Scarlet Fever
- Scarlet Fever caused by susceptible streptococci
- Secondary Syphilis
- Skin Structures and Soft Tissue Infections caused by susceptible streptococci
- Skin and Subcutaneous Tissue Bacterial Infections
- Tertiary syphilis
- Upper Respiratory Tract Infection caused by susceptible streptococci
- Yaws
- Rat bite fever
Clinical Trials
Title | Posted | Study ID | Phase | Status | Sponsor |
|---|
No clinical trials found
No clinical trials found for this drug
FDA Drug Approvals
Approved Product | Manufacturer | NDC Code | Route | Strength | Effective Date |
|---|---|---|---|---|---|
| Dispensing Solutions, Inc. | 68258-8910 | INTRAMUSCULAR | 600000 [iU] in 2 mL | 10/29/2013 | |
| Pfizer Laboratories Div Pfizer Inc | 60793-602 | INTRAMUSCULAR | 300000 [iU] in 2 mL | 9/12/2023 | |
| Pfizer Laboratories Div Pfizer Inc | 60793-600 | INTRAMUSCULAR | 600000 [iU] in 2 mL | 9/12/2023 | |
| Pfizer Laboratories Div Pfizer Inc | 60793-601 | INTRAMUSCULAR | 600000 [iU] in 2 mL | 9/12/2023 |
EMA Drug Approvals
Approved Product | Authorization Holder | Status | Issued Date |
|---|---|---|---|
| No EMA approvals found for this drug. | |||
HSA Drug Approvals
Approved Product | Manufacturer | Approval Number | Dosage Form | Strength | Approval Date |
|---|---|---|---|---|---|
| No HSA approvals found for this drug. | |||||
NMPA Drug Approvals
Approved Product | Company | Approval Number | Drug Type | Dosage Form | Approval Date |
|---|---|---|---|---|---|
| No NMPA approvals found for this drug. | |||||
PPB Drug Approvals
Approved Product | Registration No. | Company | Licence No. | Strength | Registration Date |
|---|---|---|---|---|---|
| No PPB approvals found for this drug. | |||||
TGA Drug Approvals
Approved Product | ARTG ID | Sponsor | Registration Type | Status | Registration Date |
|---|---|---|---|---|---|
| CILICAINE SYRINGE 1.5 procaine benzylpenicillin (procaine penicillin) 1.5g injection syringe | 288818 | Medicine | A | 8/4/2017 |
Health Canada Drug Approvals
Approved Product | Company | DIN | Dosage Form | Strength | Market Date |
|---|---|---|---|---|---|
| AYERCILLIN SUSPENSION | ayerst laboratories | 00002402 | Suspension - Intramuscular | 300000 UNIT / ML | 12/31/1951 |
| BICILLIN A-P INJECTION PWS | wyeth-ayerst canada inc. | 02041588 | Powder For Solution - Intramuscular | 300000 UNIT / 2 ML | 12/31/1995 |
CIMA AEMPS Drug Approvals
Approved Product | Company | Registration Number | Pharmaceutical Form | Prescription Type | Status |
|---|---|---|---|---|---|
| No CIMA AEMPS (Spain) approvals found for this drug. | |||||
Philippines FDA Drug Approvals
Approved Product | Company | License Number | Dosage Form | Strength | Approval Date |
|---|---|---|---|---|---|
| No Philippines FDA approvals found for this drug. | |||||
Saudi SFDA Drug Approvals
Approved Product | Company | License Number | Dosage Form | Strength | Approval Date |
|---|---|---|---|---|---|
| No Saudi SFDA approvals found for this drug. | |||||
Malaysia NPRA Drug Approvals
Approved Product | Company | Registration Number | Dosage Form | Strength | Approval Date |
|---|---|---|---|---|---|
| No Malaysia NPRA approvals found for this drug. | |||||
UK EMC Drug Information
Medicine Name | MA Holder | MA Number | Pharmaceutical Form | Active Ingredient | Authorization Date |
|---|---|---|---|---|---|
| No UK EMC drug information found for this drug. | |||||
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