Silibinin
- Generic Name
- Silibinin
- Brand Names
- -
- Drug Type
- Small Molecule
- Chemical Formula
- C25H22O10
- CAS Number
- 22888-70-6
- Unique Ingredient Identifier
- 33X338MNE4
- Background
Silibinin is the major active constituent of silymarin, a standardized extract of the milk thistle seeds, containing a mixture of flavonolignans consisting of silibinin, isosilibinin, silicristin, silidianin and others. Silibinin is presented as a mixture of two diastereomers, silybin A and silybin B, which are found in an approximately equimolar ratio. Both...
- Indication
Currently being tested as a treatment of severe intoxications with hepatotoxic substances, such as death cap (Amanita phalloides) poisoning.
- Associated Conditions
- Acute Hepatitis, Amanita Poisoning, Cirrhosis of the Liver, Clinical Deterioration of the Liver, Fatty Liver Disease, Hepatitis, Chronic, Non Alcoholic Steatohepatitis (NASH), Nonalcoholic Fatty Liver, Recurrent Hepatitis, Severe alcoholic liver disease, Uncomplicated hepatic dysfunction
- Associated Therapies
- -
Flavonoids attenuate inflammation of HGF and HBMSC while modulating the osteogenic ...
References discuss periodontitis, RANKL/OPG regulation by Porphyromonas gingivalis, silibinin's anti-inflammatory effects, oxidative injury in periodontal diseases, mesenchymal stem cell therapy, 2D/3D culture impacts, organ-on-a-chip applications, periodontal tissue regeneration, local adjuncts in periodontal therapy, icariin's benefits, microfluidic platforms, 3D cell printing, hMSC cocultures, osteogenesis regulation, quercetin and catechin effects, nanoemulgel development, and Wnt/β-catenin signaling.
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