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Rilzabrutinib

Generic Name: Rilzabrutinib

Drug Type: Small Molecule

Chemical Formula: C_₃₆H_₄₀FN_₉O_₃

CAS Number: 1575591-66-0

Unique Ingredient Identifier: 5G1WE425BI

Overview

Rilzabrutinib is an oral, reversible covalent inhibitor of Bruton's tyrosine kinase being investigated for the treatment of immune disorders, such as immune thrombocytopenic purpura.

Background

Rilzabrutinib is an oral, reversible covalent inhibitor of Bruton's tyrosine kinase being investigated for the treatment of immune disorders, such as immune thrombocytopenic purpura.

Indication

No indication information available.

Associated Conditions

No associated conditions information available.

Clinical Trials

The Efficacy and Safety of Rilzabrutinib in Patients Aged 10 to 65 Years With Sickle-cell Disease

Phase 3

Recruiting

Posted: 2025/05/16

Sponsor:Sanofi

ID:NCT06975865

A Study to Evaluate the Efficacy and Safety of Frexalimab, SAR442970, or Rilzabrutinib in Participants Aged 16 to 75 Years With Primary Focal Segmental Glomerulosclerosis or Minimal Change Disease

Phase 2

Recruiting

Posted: 2024/07/15

Sponsor:Sanofi

ID:NCT06500702

A Study to Evaluate the Effect of Mild and Moderate Hepatic Impairment on the Single-Dose Pharmacokinetics of Rilzabrutinib (PRN1008)

Phase 1

Completed

Posted: 2024/06/05

Sponsor:

Principia Biopharma,...

ID:NCT06444204

Pharmacokinetics (PK) of Rilzabrutinib (PRN1008) in Healthy Japanese and Caucasian Subjects

Phase 1

Completed

Posted: 2024/06/05

Sponsor:

Principia Biopharma,...

ID:NCT06444191

A Food Effect and Relative Bioavailability Study of Rilzabrutinib in Healthy Participants

Phase 1

Completed

Posted: 2024/04/02

Sponsor:Sanofi

ID:NCT06342700

FDA Approved Products

No FDA products found for this drug

Singapore Approved Products

No Singapore products found for this drug

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FDA Grants Orphan Drug Designation to Sanofi's Rilzabrutinib for Two Rare Diseases

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The FDA has granted orphan drug designation to Sanofi's rilzabrutinib for warm autoimmune hemolytic anemia (wAIHA) and IgG4-related disease (IgG4-RD), two rare conditions with no currently approved treatments.

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