Valproic acid
- Generic Name
- Valproic acid
- Brand Names
- Depakene, Depakote, Epival
- Drug Type
- Small Molecule
- Chemical Formula
- C8H16O2
- CAS Number
- 99-66-1
- Unique Ingredient Identifier
- 614OI1Z5WI
- Background
Valproic acid, or valproate, is an fatty acid derivative and anticonvulsant originally synthesized in 1881 by Beverly S. Burton. It enjoyed use as a popular organic solvent in industry and pharmaceutical manufacturing for nearly a century. In 1963, a serendipitous discovery was made by George Carraz during his investigations into the anticonvulsant effects o...
- Indication
Indicated for:
1) Use as monotherapy or adjunctive therapy in the management of complex partial seizures and simple or complex absence seizures.
2) Adjunctive therapy in the management of multiple seizure types that include absence seizures.
3) Prophylaxis of migraine headaches.
4) Acute management of mania associated with bipolar disorder.
...
- Associated Conditions
- Bipolar Disorder (BD), Complex Partial Seizure Disorder, Depressive Episodes, Migraine, Petit Mal Epilepsy, Seizure, multiple types, Acute Manic episode
- Associated Therapies
- -
Effect of Valproic Acid Concentration on Photic Response
- First Posted Date
- 2008-02-06
- Last Posted Date
- 2017-06-14
- Lead Sponsor
- Vanderbilt University Medical Center
- Target Recruit Count
- 13
- Registration Number
- NCT00609245
- Locations
- 🇺🇸
The Comprehensive Epilepsy Care Center for Children & Adults, Chesterfield, Missouri, United States
🇺🇸Vanderbilt University, Nashville, Tennessee, United States
Valproic Acid (Depakote[Registered Trademark]) to Treat Autoimmune Lymphoproliferative Syndrome (ALPS)
- Conditions
- Interventions
- First Posted Date
- 2008-01-31
- Last Posted Date
- 2013-03-21
- Lead Sponsor
- Koneti Rao
- Target Recruit Count
- 6
- Registration Number
- NCT00605657
- Locations
- 🇺🇸
National Institutes of Health Clinical Center, 9000 Rockville Pike, Bethesda, Maryland, United States
The Effect of Valproate on Benzodiazepine Withdrawal Severity
- First Posted Date
- 2007-12-10
- Last Posted Date
- 2008-10-17
- Lead Sponsor
- University of Helsinki
- Target Recruit Count
- 30
- Registration Number
- NCT00570219
- Locations
- 🇫🇮
Helsinki University Central Hospital, Department of Psychiatry, Psychiatric Unit for Drug Dependence, Helsinki, Uusimaa, Finland
Effectiveness of Lithium and Valproate in Treating High-Risk Bipolar Disorder
- First Posted Date
- 2007-11-27
- Last Posted Date
- 2012-05-01
- Lead Sponsor
- New York State Psychiatric Institute
- Target Recruit Count
- 98
- Registration Number
- NCT00563992
- Locations
- 🇺🇸
New York State Psychiatric Institute/Columbia University, New York, New York, United States
Valproic Acid and Bevacizumab in Patients With Advanced Cancer
- First Posted Date
- 2007-09-18
- Last Posted Date
- 2015-01-08
- Lead Sponsor
- M.D. Anderson Cancer Center
- Target Recruit Count
- 71
- Registration Number
- NCT00530907
- Locations
- 🇺🇸
UT MD Anderson Cancer Center, Houston, Texas, United States
Azacitidine and Valproic Acid Plus Carboplatin in Patients With Ovarian Cancer
- Conditions
- Interventions
- First Posted Date
- 2007-09-14
- Last Posted Date
- 2013-02-20
- Lead Sponsor
- M.D. Anderson Cancer Center
- Target Recruit Count
- 36
- Registration Number
- NCT00529022
- Locations
- 🇺🇸
UT MD Anderson Cancer Center, Houston, Texas, United States
Valproic Acid (Depakote ER) in Patients With Advanced Thyroid Cancer
- First Posted Date
- 2007-09-05
- Last Posted Date
- 2015-02-03
- Lead Sponsor
- University of California, San Francisco
- Target Recruit Count
- 5
- Registration Number
- NCT00525135
- Locations
- 🇺🇸
UCSF Comprehensive Cancer Center, San Francisco, California, United States
Safety and Efficiency Study of Valproic Acid In HAM/TSP
- Conditions
- First Posted Date
- 2007-08-22
- Last Posted Date
- 2007-08-22
- Lead Sponsor
- University Hospital Pierre Zobda-Quitman
- Target Recruit Count
- 19
- Registration Number
- NCT00519181
Valproate and Etoposide for Patients With Neuronal Tumors and Brain Metastases
- Conditions
- Interventions
- First Posted Date
- 2007-08-08
- Last Posted Date
- 2012-09-19
- Lead Sponsor
- M.D. Anderson Cancer Center
- Target Recruit Count
- 8
- Registration Number
- NCT00513162
- Locations
- 🇺🇸
UT MD Anderson Cancer Center, Houston, Texas, United States
Azacytidine and Valproic Acid in Patients With Advanced Cancers
- First Posted Date
- 2007-07-04
- Last Posted Date
- 2012-08-01
- Lead Sponsor
- M.D. Anderson Cancer Center
- Target Recruit Count
- 69
- Registration Number
- NCT00496444
- Locations
- 🇺🇸
U.T.M.D. Anderson Cancer Center, Houston, Texas, United States
Drug Development Updates
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