Prostaglandin E2
- Generic Name
- Prostaglandin E2
- Brand Names
- Cervidil, Prepidil, Prostin E2
- Drug Type
- Small Molecule
- Chemical Formula
- C20H32O5
- CAS Number
- 363-24-6
- Unique Ingredient Identifier
- K7Q1JQR04M
- Background
Dinoprostone is a naturally occurring prostaglandin E2 (PGE2). It has important effects in labour. It also stimulates osteoblasts to release factors which stimualtes bone resorption by osteoclasts. As a prescription drug it is used as a vaginal suppository, to prepare the cervix for labour and to induce labour.
- Indication
For the termination of pregnancy during the second trimester (from the 12th through the 20th gestational week as calculated from the first day of the last normal menstrual period), as well as for evacuation of the uterine contents in the management of missed abortion or intrauterine fetal death up to 28 weeks of gestational age as calculated from the first d...
- Associated Conditions
- Gestational Trophoblastic Neoplasia
- Associated Therapies
- Induction of cervix ripening therapy, Medically induced abortion, Uterus evacuation
Premature Rupture of Membranes With a Bishop Score<6: Comparison of Medical Induction/Expectant Management
- Conditions
- Interventions
- First Posted Date
- 2016-07-07
- Last Posted Date
- 2022-10-26
- Lead Sponsor
- Rambam Health Care Campus
- Target Recruit Count
- 458
- Registration Number
- NCT02825641
- Locations
- đźđ±
Rambam health care campus, Haifa, Israel
Comparing Cervical Foley Catheter, Dinoprostone and a Combination of the Two for Labor Induction
- Conditions
- Interventions
- First Posted Date
- 2016-06-28
- Last Posted Date
- 2016-07-01
- Lead Sponsor
- Kaplan Medical Center
- Target Recruit Count
- 360
- Registration Number
- NCT02815865
Oxytocin vs. Prostaglandin for Induction of Labor in Primiparas With Prelabor Rupture of Membrane and Low Bishop
- Conditions
- Interventions
- First Posted Date
- 2016-06-15
- Last Posted Date
- 2016-06-15
- Lead Sponsor
- Shaare Zedek Medical Center
- Target Recruit Count
- 68
- Registration Number
- NCT02801227
Comparing the Efficiency of Cervical Ripening BALLoon (Cook) to the DINOprostone (Propess) for the Cervical Maturation in Case of Unfavorable Cervix (Bishop <6) in the Population of Obese Pregnant Women (BMI >= 30 kg/mÂČ)
- Conditions
- Interventions
- First Posted Date
- 2016-01-08
- Last Posted Date
- 2024-08-15
- Lead Sponsor
- Centre Hospitalier Departemental Vendee
- Target Recruit Count
- 2
- Registration Number
- NCT02649920
- Locations
- đ«đ·
Centre Hospitalier Vendée, La Roche sur Yon, France
đ«đ·Centre Hospitalier, Le Mans, France
Concurrent Oxytocin With Membrane Sweeping Versus Dinoprostone Pessary in Labor Induction of Multiparous Women at Term
- Conditions
- Interventions
- First Posted Date
- 2015-12-01
- Last Posted Date
- 2020-03-04
- Lead Sponsor
- Seoul National University Hospital
- Target Recruit Count
- 154
- Registration Number
- NCT02618096
- Locations
- đ°đ·
Department of Obstetrics and Gynecology Seoul National University Bundang Hospital, Seongnam-si, Gyeonggi-do, Korea, Republic of
Concurrent Oxytocin With Membrane Sweeping Versus Dinoprostone Pessary in Labor Induction of Nulliparas at Term
- Conditions
- Interventions
- First Posted Date
- 2015-04-15
- Last Posted Date
- 2020-03-03
- Lead Sponsor
- Seoul National University Hospital
- Target Recruit Count
- 140
- Registration Number
- NCT02416583
- Locations
- đ°đ·
Department of Obstetrics and Gynecology Seoul National University Bundang Hospital, Seongnam-si, Gyeonggi-do, Korea, Republic of
Oral Misoprostol Versus Vaginal Dinoprostone For Induction Of Labour: A Randomized Controlled Clinical Trial
- First Posted Date
- 2014-06-20
- Last Posted Date
- 2014-06-20
- Lead Sponsor
- Ain Shams University
- Target Recruit Count
- 342
- Registration Number
- NCT02168881
- Locations
- đȘđŹ
Ain Shams Maternity hospital, Cairo, Egypt
Randomized Controlled Trial: Induction of Labour of Obese Women With Dinoprostone or Single Balloon Catheter
- Conditions
- Interventions
- First Posted Date
- 2013-10-14
- Last Posted Date
- 2016-10-13
- Lead Sponsor
- Saskatchewan Health Authority - Regina Area
- Target Recruit Count
- 41
- Registration Number
- NCT01962831
- Locations
- đšđŠ
Regina Qu'Appelle Health Region, Regina, Saskatchewan, Canada
Comparison Between 25 ”g Vaginal Misoprostol vs Slow Release Pessary PGE2
- First Posted Date
- 2013-01-10
- Last Posted Date
- 2016-04-28
- Lead Sponsor
- University Hospital, Toulouse
- Target Recruit Count
- 1700
- Registration Number
- NCT01765881
- Locations
- đ«đ·
BicĂȘtre Hospital, Le Kremlin-BicĂȘtre, France
đ«đ·Hospital Poissy, Poissy, France
đ«đ·HĂŽpitaux Universitaires de Strasbourg, Strasbourg, France
Efficacy of Induction of Labor on Term Using a Double Balloon Catheter Compared to Dinoprostone Vaginal-insert
- Conditions
- Interventions
- First Posted Date
- 2012-11-02
- Last Posted Date
- 2018-09-11
- Lead Sponsor
- Medical University of Graz
- Target Recruit Count
- 253
- Registration Number
- NCT01720394
- Locations
- đŠđč
UniversitÀtsfrauenklinik Innsbruck, Medizinische UniversitÀt Innsbruck, Innsbruck, Austria
đŠđčUniversitĂ€tsklinik fĂŒr Frauenheilkunde und Geburtshilfe, Medizinische UniversitĂ€t Graz, Graz, Austria
đŠđčUniversitĂ€tsfrauenklinik Wien, Abteilung fĂŒr Geburtshilfe und fetomaternale Medizin, Medizinische UniversitĂ€t Wien, Vienna, Austria
Drug Development Updates
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