Acetazolamide

Generic Name: Acetazolamide

Brand Names: -

Drug Type: Small Molecule

Chemical Formula: C_₄H_₆N_₄O_₃S_₂

CAS Number: 59-66-5

Unique Ingredient Identifier: O3FX965V0I

Background: One of the carbonic anhydrase inhibitors that is sometimes effective against absence seizures. It is sometimes useful also as an adjunct in the treatment of tonic-clonic, myoclonic, and atonic seizures, particularly in women whose seizures occur or are exacerbated at specific times in the menstrual cycle. However, its usefulness is transient often because of rapid development of tolerance. Its antiepileptic effect may be due to its inhibitory effect on brain carbonic anhydrase, which leads to an increased transneuronal chloride gradient, increased chloride current, and increased inhibition. (From Smith and Reynard, Textbook of Pharmacology, 1991, p337)

Indication: For adjunctive treatment of: edema due to congestive heart failure; drug-induced edema; centrencephalic epilepsies; chronic simple (open-angle) glaucoma

Associated Conditions: Acute angle-closure glaucoma, Edema, Familial periodic paralysis, Generalized Tonic-Clonic Seizures, Metabolic Alkalosis, Open Angle Glaucoma (OAG), Other and unspecified effects of high altitude, Cystine renal calculi, Drug-induced edema, Nonuveitic secondary glaucoma, Salicylate intoxication

Associated Therapies: Urine alkalinization therapy

Clinical Trials

Effect of Antiglaucoma Agents on Short Term Intraocular Pressure Fluctuations After Intravitreal Bevacizumab Injection

Not Applicable

Completed

Conditions: Intraocular Pressure Change in Intravitreal Injection

Interventions: Drug: Timolol
Drug: Brimonidine
Drug: Acetazolamide
Drug: Mannitol
Drug: Placebo

First Posted Date: 2014-05-16

Last Posted Date: 2014-05-16

Lead Sponsor: Mashhad University of Medical Sciences

Target Recruit Count: 70

Registration Number: NCT02140450

Locations: 🇮🇷
Retina Research Center, Khatam eye Hospital, Mashhad, Khorasan Razavi, Iran, Islamic Republic of

Immediate Anterior Chamber Paracentesis With A 30-Gauge Needle for Acute Primary Angle - Closure

Not Applicable

Completed

Conditions: Glaucoma, Angle-closure

Interventions: Procedure: Paracentesis
Drug: Acetazolamide
Procedure: Peripheral iridotomy

First Posted Date: 2013-08-15

Last Posted Date: 2013-08-15

Lead Sponsor: Siriraj Hospital

Target Recruit Count: 15

Registration Number: NCT01923454

Locations: 🇹🇭
Naris Kitnarong, Bangkok, Thailand

Effectiveness of Acetazolamide in Reducing Paralysis of the Leg in Patients Undergoing Aortic Aneurysm Surgery Surgery

Phase 4

Conditions: Thoracic Aneurysm

Interventions: Drug: Acetazolamide

First Posted Date: 2013-06-28

Last Posted Date: 2014-12-31

Lead Sponsor: Liverpool Heart and Chest Hospital NHS Foundation Trust

Target Recruit Count: 100

Registration Number: NCT01889498

Locations: 🇬🇧
Liverpool heart & chest hospital, Liverpool, United Kingdom
🇬🇧
Liverpool Heart & Chest Hospital, Liverpool, United Kingdom

Effect of Acetazolamide & Position in CSF Leakage and Collection and Wound Dehiscence

Phase 2

Conditions: Tumor
Tethered Cord Syndrome
Lipomyelomeningocele
Dermal Sinus
Fibrolipoma of Filum Terminale
Split Cord Malformation

Interventions: Other: prone positioning
Drug: Acetazolamide
Other: Acetazolamide+ prone positioning

First Posted Date: 2013-06-03

Last Posted Date: 2015-04-21

Lead Sponsor: Tehran University of Medical Sciences

Target Recruit Count: 144

Registration Number: NCT01867268

Locations: 🇮🇷
Children'S Medical Center, Tehran, Iran, Islamic Republic of

Interactions Between Intravenous Cocaine and Acetazolamide or Quinine

Phase 1

Completed

Conditions: Cocaine Use
Pharmacokinetics

First Posted Date: 2013-05-10

Last Posted Date: 2018-07-05

Lead Sponsor: National Institute on Drug Abuse (NIDA)

Target Recruit Count: 14

Registration Number: NCT01851473

Locations: 🇺🇸
National Institute on Drug Abuse, Baltimore, Maryland, United States

Acetazolamide's Headache Inducing Characteristics and Effects on the Cerebral Arteries and Blood Flow

Not Applicable

Completed

Conditions: Migraine
Headache

Interventions: Drug: Acetazolamide

First Posted Date: 2012-12-17

Last Posted Date: 2013-07-09

Lead Sponsor: Danish Headache Center

Target Recruit Count: 12

Registration Number: NCT01750723

Locations: 🇩🇰
Department of Neurology, Copenhagen, Glostrup, Denmark
🇩🇰
Danish Headache Center, Copenhagen, Glostrup, Denmark

Effectiveness of Acetazolamide for Reversal of Metabolic Alkalosis in Mechanically Ventilated Chronic Obstructive Pulmonary Disease Patients

Phase 4

Completed

Conditions: Decompensated Chronic Obstructive Pulmonary Disease

Interventions: Drug: Acetazolamide
Drug: Placebo

First Posted Date: 2012-06-26

Last Posted Date: 2015-10-06

Lead Sponsor: Assistance Publique - Hôpitaux de Paris

Target Recruit Count: 380

Registration Number: NCT01627639

Locations: 🇫🇷
Clinical Research Unit, European Georges Pompidou Hospital, Assistance Publique - Hôpitaux de Paris, Paris, France

Comparison of Temazepam and Acetazolamide to Treat Difficulty Sleeping at High Altitude

Not Applicable

Completed

Conditions: High-altitude Sleep Disturbance

Interventions: Drug: Acetazolamide
Drug: Temazepam

First Posted Date: 2012-01-27

Last Posted Date: 2015-04-23

Lead Sponsor: Massachusetts General Hospital

Target Recruit Count: 34

Registration Number: NCT01519544

Locations: 🇳🇵
Himalayan Rescue Location clinic in Manang, Manang, District of Manang, Nepal

Treatment of Metabolic Alkalosis With Acetazolamide. Effect on the Length of Mechanical Ventilation.

Phase 3

Completed

Conditions: Obesity Hypoventilation Syndrome
Metabolic Alkalosis
Pulmonary Disease, Chronic Obstructive

Interventions: Drug: Acetazolamide
Drug: Placebo

First Posted Date: 2011-12-26

Last Posted Date: 2015-03-17

Lead Sponsor: Hospital Son Llatzer

Target Recruit Count: 140

Registration Number: NCT01499485

Locations: 🇪🇸
Hospital de Manacor, Manacor, Illes Balears, Spain
🇪🇸
Fundación Jiménez Díaz, Madrid, Comunidad de Madrid, Spain
🇪🇸
Hospital Son Espases, Palma de Mallorca, Illes Balears, Spain

and more 5 locations

Treatment of Sleep Related Breathing Disorders in Patients With Pulmonary Hypertension

Phase 2

Completed

Conditions: Pulmonary Hypertension
Breathing-Related Sleep Disorder

Interventions: Drug: Placebo tablet
Drug: acetazolamide
Other: Supplemental oxygen
Procedure: Non-invasive ventilation
Other: Room air

First Posted Date: 2011-09-01

Last Posted Date: 2012-12-12

Lead Sponsor: University of Zurich

Target Recruit Count: 23

Registration Number: NCT01427192

Locations: 🇨🇭
Respiratory Clinic, University Hospital of Zurich, Zurich, Switzerland

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