MedPath

Cyproheptadine

Generic Name
Cyproheptadine
Drug Type
Small Molecule
Chemical Formula
C21H21N
CAS Number
129-03-3
Unique Ingredient Identifier
2YHB6175DO

Overview

Cyproheptadine is a potent competitive antagonist of both serotonin and histamine receptors. It is used primarily to treat allergic symptoms, though it is perhaps more notable for its use in appetite stimulation and its off-label use in the treatment of serotonin syndrome.

Background

Cyproheptadine is a potent competitive antagonist of both serotonin and histamine receptors. It is used primarily to treat allergic symptoms, though it is perhaps more notable for its use in appetite stimulation and its off-label use in the treatment of serotonin syndrome.

Indication

In the US, prescription cyproheptadine is indicated for the treatment of various allergic symptomatologies - including dermatographia, rhinitis, conjunctivitis, and urticaria - as well as adjunctive therapy in the management of anaphylaxis following treatment with epinephrine. In Canada, cyproheptadine is available over-the-counter and is indicated for the treatment of pruritus and for appetite stimulation. In Australia, cyproheptadine is additionally indicated for the treatment vascular headaches. Cyproheptadine is also used off-label for the treatment of serotonin syndrome.

Associated Conditions

  • Allergic Reactions caused by Transfusions
  • Anaphylaxis
  • Angioedema and urticaria
  • Cold urticaria
  • Conjunctivitis allergic caused by Food Allergy
  • Conjunctivitis allergic caused by inhalant allergens
  • Perennial Allergic Rhinitis (PAR)
  • Pruritus
  • Seasonal Allergic Rhinitis
  • Serotonin Syndrome
  • Vasomotor Rhinitis
  • Dermatographism

FDA Approved Products

CYPROHEPTADINE HYDROCHLORIDE
Manufacturer:Strides Pharma Science Limited
Route:ORAL
Strength:4 mg in 1 1
Approved: 2022/11/22
NDC:64380-795
Cyproheptadine Hydrochloride
Manufacturer:Chartwell RX, LLC
Route:ORAL
Strength:4 mg in 1 1
Approved: 2023/01/27
NDC:62135-236
CYPROHEPTADINE HYDROCHLORIDE
Manufacturer:Ingenus Pharmaceuticals LLC
Route:ORAL
Strength:4 mg in 1 1
Approved: 2017/12/18
NDC:50742-190
Cyproheptadine Hydrochloride
Manufacturer:State of Florida DOH Central Pharmacy
Route:ORAL
Strength:4 mg in 1 1
Approved: 2015/01/03
NDC:53808-1030
CYPROHEPTADINE HYDROCHLORIDE
Manufacturer:QUAGEN PHARMACEUTICALS LLC
Route:ORAL
Strength:4 mg in 1 1
Approved: 2022/07/08
NDC:70752-107

Singapore Approved Products

No Singapore products found for this drug

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