Cyproheptadine
- Generic Name
- Cyproheptadine
- Brand Names
- -
- Drug Type
- Small Molecule
- Chemical Formula
- C21H21N
- CAS Number
- 129-03-3
- Unique Ingredient Identifier
- 2YHB6175DO
- Background
Cyproheptadine is a potent competitive antagonist of both serotonin and histamine receptors. It is used primarily to treat allergic symptoms, though it is perhaps more notable for its use in appetite stimulation and its off-label use in the treatment of serotonin syndrome.
- Indication
In the US, prescription cyproheptadine is indicated for the treatment of various allergic symptomatologies - including dermatographia, rhinitis, conjunctivitis, and urticaria - as well as adjunctive therapy in the management of anaphylaxis following treatment with epinephrine. In Canada, cyproheptadine is available over-the-counter and is indicated for the treatment of pruritus and for appetite stimulation. In Australia, cyproheptadine is additionally indicated for the treatment vascular headaches.
Cyproheptadine is also used off-label for the treatment of serotonin syndrome.
- Associated Conditions
- Allergic Reactions caused by Transfusions, Anaphylaxis, Angioedema and urticaria, Cold urticaria, Conjunctivitis allergic caused by Food Allergy, Conjunctivitis allergic caused by inhalant allergens, Perennial Allergic Rhinitis (PAR), Pruritus, Seasonal Allergic Rhinitis, Serotonin Syndrome, Vasomotor Rhinitis, Dermatographism
- Associated Therapies
- Appetite stimulation
Molecular Markers of Neuroplasticity During Exercise in People With Incomplete Spinal Cord Injury
- Conditions
- Spinal Cord Injury
- Interventions
- First Posted Date
- 2012-02-24
- Last Posted Date
- 2015-05-19
- Lead Sponsor
- T. George Hornby
- Target Recruit Count
- 30
- Registration Number
- NCT01538693
- Locations
- 🇺🇸
Rehabiliation Institute of Chicago, Chicago, Illinois, United States
Cyproheptadine as an Appetite Stimulant
- First Posted Date
- 2011-03-15
- Last Posted Date
- 2011-03-15
- Lead Sponsor
- St. Justine's Hospital
- Target Recruit Count
- 20
- Registration Number
- NCT01314989
- Locations
- 🇨🇦
Ste-Justine University Health Center, Montreal, Quebec, Canada
A Study on the Biobehavioral Mechanisms of Baclofen and Alcohol Drinking
- First Posted Date
- 2010-02-26
- Last Posted Date
- 2013-10-17
- Lead Sponsor
- Brown University
- Target Recruit Count
- 14
- Registration Number
- NCT01076283
- Locations
- 🇺🇸
Brown University Center for Alcohol and Addiction Studies, Providence, Rhode Island, United States
Drug Development Updates
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