Avatrombopag
- Generic Name
- Avatrombopag
- Brand Names
- Doptelet 60 Mg Daily Dose Carton, Doptelet
- Drug Type
- Small Molecule
- Chemical Formula
- C29H34Cl2N6O3S2
- CAS Number
- 570406-98-3
- Unique Ingredient Identifier
- 3H8GSZ4SQL
- Background
Avatrombopag (Doptelet), is an orally administered, small-molecule thrombopoietin receptor (c-Mpl) agonist which increases platelet number, but not platelet activation , . This decreases the need for blood transfusions .
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- Indication
Indicated for the treatment of thrombocytopenia in adult patients with chronic liver disease who are scheduled to undergo a procedure .
- Associated Conditions
- Thrombocytopenia
- Associated Therapies
- -
A Five-Treatment-Period Study to Evaluate the Single-Dose Pharmacokinetics and Pharmacodynamics of Avatrombopag in Healthy Japanese and White Subjects
- First Posted Date
- 2014-01-17
- Last Posted Date
- 2014-12-18
- Lead Sponsor
- Eisai Inc.
- Target Recruit Count
- 48
- Registration Number
- NCT02039076
- Locations
- 🇺🇸
Parexel International Early Development Clinical Units, Glendale, California, United States
Efficacy and Safety of Oral E5501 Plus Standard of Care for the Treatment of Thrombocytopenia in Adults With Chronic Immune Thrombocytopenia (Amendment 02)
- Conditions
- Interventions
- First Posted Date
- 2011-09-22
- Last Posted Date
- 2018-02-05
- Lead Sponsor
- Eisai Inc.
- Target Recruit Count
- 49
- Registration Number
- NCT01438840
A Phase 3, Multicenter, Randomized, Double-blind,Active-controlled, Parallel-group Trial With an Open-labelExtension Phase to Evaluate the Efficacy and Safety of OralE5501 Versus Eltrombopag, in Adults With Chronic ImmuneThrombocytopenia (Idiopathic Thrombocytopenic Purpura)
- Conditions
- Interventions
- First Posted Date
- 2011-09-14
- Last Posted Date
- 2018-02-06
- Lead Sponsor
- Eisai Inc.
- Target Recruit Count
- 24
- Registration Number
- NCT01433978
- Locations
- 🇺🇸
Prairie Lakes Health Care System, Watertown, South Dakota, United States
Chronic Hepatitis C Virus Related Thrombocytopenia to Evaluate the Effects of E5501
- Conditions
- Interventions
- First Posted Date
- 2011-05-18
- Last Posted Date
- 2018-02-22
- Lead Sponsor
- Eisai Inc.
- Target Recruit Count
- 65
- Registration Number
- NCT01355289
- Locations
- 🇺🇸
Health Care Consultants, Los Angeles, California, United States
🇺🇸Metropolitan Research, Fairfax, Virginia, United States
Once-Daily Oral Avatrombopag Tablets Used in Subjects With Chronic Liver Diseases and Thrombocytopenia Prior to Elective Surgical or Diagnostic Procedures
- Conditions
- Interventions
- First Posted Date
- 2009-06-05
- Last Posted Date
- 2018-01-23
- Lead Sponsor
- Eisai Inc.
- Target Recruit Count
- 130
- Registration Number
- NCT00914927
- Locations
- 🇺🇸
Ochsner Clinic Foundation, New Orleans, Louisiana, United States
Drug Development Updates
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