Benzocaine

Generic Name
Benzocaine
Brand Names
Anbesol Cold Sore Therapy, Cepacol Sore Throat Plus Cough, Cetacaine, Chloraseptic Sore Throat, Chloraseptic Sore Throat + Cough, Diphen, Docusol Plus, Enemeez Plus, Medicaine Sting and Bite, One Touch Reformulated Apr 2009, Orasep Reformulated Dec 2013, Rectogel, Salinocaine, Topex, Vagisil Original Formula, Zap, Zilactin-B
Drug Type
Small Molecule
Chemical Formula
C9H11NO2
CAS Number
94-09-7
Unique Ingredient Identifier
U3RSY48JW5
Background

Benzocaine is an ester local anesthetic that acts by preventing transmission of impulses along nerve fibers and at nerve endings. It is commonly used for local anesthesia in many over the counter products. Benzocaine was first used for local anesthesia in dentistry.

Indication

Benzocaine is indicated for local anesthesia in dentistry, minor trauma, and as preparation for infiltrative anesthesia. Benzocaine products are indicated for topical anesthesia in a wide variety of conditions including skin irritation, oral pain, and hemorrhoids.

Associated Conditions
Acute Sore Throat Pain, Dental Pain, Gangrene Stomatitis, Gingivitis, Haemorrhoids, Laryngitis, Pharyngitis, Premature Ejaculation, Secondary Bacterial Infection caused by Tonsillectomy, Secondary Bacterial Infection caused by Tooth Extractions, Skin Irritation, Sore Throat, Stomatitis, Sunburn, Teething pain, Tonsillitis, Tooth Pain, Vomiting, Pruritic dermatosis, Ulceration of the mouth
Associated Therapies
Buccopharyngeal anesthesia

Role of the Foregut in Nutrient Metabolism in Lean and Obese Humans

Phase 1
Completed
Conditions
Interventions
First Posted Date
2015-09-01
Last Posted Date
2022-12-09
Lead Sponsor
Vanderbilt University Medical Center
Target Recruit Count
27
Registration Number
NCT02537314
Locations
🇺🇸

Vanderbilt University Medical Center, Nashville, Tennessee, United States

Study to Assess the Safety and Efficacy of Benzocaine for Pain Relief in Children Presenting With Acute Otitis Media

Phase 2
Completed
Conditions
Interventions
First Posted Date
2014-03-20
Last Posted Date
2015-05-25
Lead Sponsor
Otic Therapy, LLC
Target Recruit Count
65
Registration Number
NCT02092454

Comparison of Two Topical Anesthetics: Benzocaine Versus Pliaglis

First Posted Date
2013-09-27
Last Posted Date
2016-07-22
Lead Sponsor
University of Michigan
Target Recruit Count
64
Registration Number
NCT01951820
Locations
🇺🇸

University of Michigan Dental School, Ann Arbor, Michigan, United States

Benzocaine Versus Placebo Spray for Pain Relief at Hysterosalpingogram

Phase 4
Completed
Conditions
Interventions
First Posted Date
2013-08-19
Last Posted Date
2017-04-28
Lead Sponsor
University of Pennsylvania
Target Recruit Count
30
Registration Number
NCT01925469
Locations
🇺🇸

University of Pennsylvania, Philadelphia, Pennsylvania, United States

Study of FAECC Scale (Modified FLACC) to Evaluate Ear Pain in Children With Acute Otitis Media

Phase 2
Completed
Conditions
Interventions
First Posted Date
2012-05-01
Last Posted Date
2015-05-04
Lead Sponsor
Arbor Pharmaceuticals, Inc.
Target Recruit Count
38
Registration Number
NCT01588535
Locations
🇺🇸

DiscoveReseach, Inc., Bryan, Texas, United States

🇺🇸

COMMUNITY Medical Research, Miami Beach, Florida, United States

🇺🇸

Nda Baptist Clinic, Jonesboro, Arkansas, United States

and more 11 locations

Comparative Efficacy of 20% Benzocaine Versus TAC Alternate Gel

First Posted Date
2009-02-19
Last Posted Date
2009-02-19
Lead Sponsor
The University of Texas Health Science Center, Houston
Target Recruit Count
20
Registration Number
NCT00846690
Locations
🇺🇸

UT Pediatric Dentistry Clinic Houston Medical Center, 6655 Travis Suite 460, Texas, United States

Benzocaine Gel Toothache Dose-Response Study

Phase 4
Completed
Conditions
Interventions
First Posted Date
2007-05-16
Last Posted Date
2013-02-28
Lead Sponsor
Wyeth is now a wholly owned subsidiary of Pfizer
Target Recruit Count
577
Registration Number
NCT00474175
Locations
🇺🇸

Pfizer Investigational Site, Pittsburgh, Pennsylvania, United States

Efficacy and Tolerability of Ambroxol Lozenge 20 mf in Relieving Pain of Sore Throat in Pat. With Acute/Viralpharyngitis

Phase 3
Completed
Conditions
First Posted Date
2005-09-08
Last Posted Date
2017-12-28
Lead Sponsor
Boehringer Ingelheim
Target Recruit Count
751
Registration Number
NCT00148499
Locations
🇷🇴

Medicover, Bucharest, Romania

🇺🇦

City Clinical Otolaryngological Hospital, Kharkov, Ukraine

🇷🇴

Victor Babes Clincial Hospital, Bucharest, Romania

and more 7 locations
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