Treatment with camrelizumab, rivoceranib, and chemotherapy (SOXRC) showed better pre- and postsurgical responses in advanced gastric cancer compared to chemotherapy alone (SOX). The phase 3 DRAGON IV/CAP 05 study reported pathologic complete response rates of 18.3% vs. 5% and major pathologic response rates of 51.1% vs. 37.8% in the SOXRC and SOX groups, respectively. The study suggests an early signal of efficacy for combined PD-1/VEGFR inhibition plus chemotherapy, though not yet ready for routine use.