Mannitol

Generic Name
Mannitol
Brand Names
Aridol, Bronchitol, Cystosol, Osmitrol, Sag-M
Drug Type
Small Molecule
Chemical Formula
C6H14O6
CAS Number
69-65-8
Unique Ingredient Identifier
3OWL53L36A
Background

Mannitol is an osmotic diuretic that is metabolically inert in humans and occurs naturally, as a sugar or sugar alcohol, in fruits and vegetables. Mannitol elevates blood plasma osmolality, resulting in enhanced flow of water from tissues, including the brain and cerebrospinal fluid, into interstitial fluid and plasma. As a result, cerebral edema, elevated i...

Indication

Used for the promotion of diuresis before irreversible renal failure becomes established, the reduction of intracranial pressure, the treatment of cerebral edema, and the promotion of urinary excretion of toxic substances.
...

Associated Conditions
Acute Renal Failure (ARF), Cystic Fibrosis (CF), Edema of the cerebrum, Increased Intra Ocular Pressure (IOP)
Associated Therapies
Bladder irrigation therapy
Clinical Trials
Related News

Evaluation of the Performance of Two Neutral Oral Contrast Agents in CT Enterography

Not Applicable
Conditions
CTE
Interventions
Drug: mannitol
Drug: polyethylene glycol
First Posted Date
2018-04-12
Last Posted Date
2018-08-24
Lead Sponsor
Shandong University
Target Recruit Count
60
Registration Number
NCT03495804
Locations
🇨🇳

Department of Gastroenterology, Qilu Hospital, Shandong University, Jinan, Shandong, China

The Therapeutic Time Window of Mannitol During Craniotomy for Optimal Brain Relaxation in Patients With Supratentorial Tumours

Not Applicable
Completed
Conditions
Supratentorial Tumors
Interventions
Drug: Mannitol
First Posted Date
2018-02-23
Last Posted Date
2020-11-20
Lead Sponsor
Huashan Hospital
Target Recruit Count
100
Registration Number
NCT03444519
Locations
🇨🇳

Fudan University affiliated Huashan Hospital, Shanghai, Shanghai, China

Coagulation Activation by Hyperosmolar Agents in Intracranial Hypertension

First Posted Date
2018-01-24
Last Posted Date
2020-11-19
Lead Sponsor
Neuromed IRCCS
Registration Number
NCT03409237
Locations
🇮🇹

IRCCS INM Neuromed, Department of Epidemiology and Prevention, Pozzilli, IS, Italy

Effect of Mannitol on Optic Nerve Sheath Diameter in Patients Undergoing Robotic Prostatectomy

Completed
Conditions
Prostate Cancer
First Posted Date
2017-07-11
Last Posted Date
2017-08-25
Lead Sponsor
Asan Medical Center
Target Recruit Count
39
Registration Number
NCT03214055
Locations
🇰🇷

Asan Medical center, Seoul, Korea, Republic of

Effect of Allopurinol for Hypoxic-ischemic Brain Injury on Neurocognitive Outcome

First Posted Date
2017-05-22
Last Posted Date
2023-07-11
Lead Sponsor
University Hospital Tuebingen
Target Recruit Count
760
Registration Number
NCT03162653
Locations
🇫🇮

Helsingin Ja Uudenmaan Sairaanhoitopiirin Kuntayhtymä, Helsinki, Finland

🇵🇱

Uniwersytet Medyczny Im Karola Marcinkowskiego W Poznaniu, Poznań, Poland

🇪🇪

Tartu Ulikool, Tartu, Estonia

and more 9 locations

Assessment of Oncological and Functional Outcomes After Robot Assisted Partial Nephrectomy Versus Laparoscopic Partial Nephrectomy

First Posted Date
2016-10-05
Last Posted Date
2020-09-01
Lead Sponsor
Luzerner Kantonsspital
Target Recruit Count
85
Registration Number
NCT02924922
Locations
🇨🇭

Klinik für Urologie, Kantonsspital Luzern, Luzern, Switzerland

Evaluation of the Effect of Acetazolamide, Mannitol and N-acetylcysteine on Cisplatin-Induced Nephrotoxicity

First Posted Date
2016-05-04
Last Posted Date
2017-01-24
Lead Sponsor
Ain Shams University
Target Recruit Count
52
Registration Number
NCT02760901

Topical Menthol +/- Mannitol for Painful Diabetic Peripheral Neuropathy

Phase 1
Completed
Conditions
Diabetic Peripheral Neuropathy
Interventions
Drug: Menthol
Drug: Mannitol
First Posted Date
2016-04-05
Last Posted Date
2021-03-02
Lead Sponsor
University of British Columbia
Target Recruit Count
72
Registration Number
NCT02728687
Locations
🇨🇦

Dr. Helene Bertrand Inc., 220-1940 Lonsdale Ave., North Vancouver, British Columbia, Canada

🇨🇦

Private Physician's Office, Courtenay, British Columbia, Canada

🇨🇦

Okanagan Interventional Pain Clinic,, Kelowna, British Columbia, Canada

and more 2 locations

High Volume Plasma Exchange in Children With Acute Liver Failure and Acute on Chronic Liver Failure

First Posted Date
2016-03-25
Last Posted Date
2018-12-06
Lead Sponsor
Institute of Liver and Biliary Sciences, India
Target Recruit Count
75
Registration Number
NCT02719210
Locations
🇮🇳

Institute of liver and Biliary Sciences, New Delhi, Delhi, India

Brain Relaxation With Mannitol and Furosemide

Not Applicable
Completed
Conditions
Brain Tumors
Interventions
Drug: mannitol
Drug: Furosemide
Drug: placebo
First Posted Date
2016-03-18
Last Posted Date
2016-03-18
Lead Sponsor
Istanbul University
Target Recruit Count
47
Registration Number
NCT02712476
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