Bupivacaine
- Generic Name
- Bupivacaine
- Brand Names
- Exparel, Kenalog, Marbeta, Marcaine, Marcaine With Epinephrine, Marvona Suik, P-Care M, P-Care MG, P-care, Posimir, Readysharp Anesthetics Plus Ketorolac, Readysharp-A, Readysharp-p40, Readysharp-p80, Sensorcaine, Sensorcaine With Epinephrine, Vivacaine, Xaracoll, Exparel liposomal
- Drug Type
- Small Molecule
- Chemical Formula
- C18H28N2O
- CAS Number
- 38396-39-3
- Unique Ingredient Identifier
- Y8335394RO
- Background
Bupivacaine is a widely used local anesthetic agent.
- Indication
As an implant, bupivacaine is indicated in adults for placement into the surgical site to produce postsurgical analgesia for up to 24 hours following open inguinal hernia repair.
Bupivacaine, in liposome suspension, is indicated in patients aged 6 years and older for single-dose infiltration to produce postsurgical local analgesia. In adults, it is also indicated as an interscalene brachial plexus nerve block to produce postsurgical regional analgesia.
Bupivacaine, in combination with meloxicam, is indicated for postsurgical analgesia in adult patients for up to 72 hours following foot and ankle, small-to-medium open abdominal, and lower extremity total joint arthroplasty surgical procedures.
Bupivacaine, alone or in combination with epinephrine, is indicated in adults for the production of local or regional anesthesia or analgesia for surgery, dental and oral surgery procedures, diagnostic and therapeutic procedures, and for obstetrical procedures. Specific concentrations and presentations are recommended for each type of block indicated to produce local or regional anesthesia or analgesia. Finally, its use is not indicated in all blocks given clinically significant risks associated with use.
- Associated Conditions
- Acute Gouty Arthritis, Adrenocortical Insufficiency, Alopecia Areata (AA), Ankylosing Spondylitis (AS), Berylliosis, Bullous dermatitis herpetiformis, Congenital Adrenal Hyperplasia (CAH), Congenital Hypoplastic Anemia, Dermatomyositis (DM), Discoid Lupus Erythematosus (DLE), Edema of the cerebrum, Epicondylitis, Hemolytic Anemia, Hypercalcemia caused by Cancer, Keloids Scars, Leukemias, Mycosis Fungoides (MF), Necrobiosis lipoidica diabeticorum, Ocular Inflammation, Ophthalmia, Sympathetic, Osteoarthritis (OA), Pain, Labor, Polymyositis, Postoperative pain, Psoriatic Arthritis, Psoriatic plaque, Pure Red Cell Aplasia, Regional Enteritis, Rheumatoid Arthritis, Secondary thrombocytopenia, Stevens-Johnson Syndrome, Synovitis, Systemic Lupus Erythematosus, Temporal Arteritis, Trichinosis, Tuberculous Meningitis, Ulcerative Colitis, Uveitis, Acute Bursitis, Acute Idiopathic Nephrotic Syndrome, Acute Lupus Erythematosus, Acute Multiple sclerosis, Acute Rheumatic heart disease, unspecified, Acute nonspecific tenosynovitis, Cystic tumors of aponeurosis, Cystic tumors of tendon, Disseminated Pulmonary Tuberculosis (TB), Exfoliative erythroderma, Inflammatory lesions of granuloma annulare, Inflammatory lesions of lichen planus, Inflammatory lesions of lichen simplex, Non-suppurative Thyroiditis, Permphigus, Severe Allergic Reactions
- Associated Therapies
- General Anesthesia, Local Anaesthesia therapy, Regional nerve block therapy
Ultrasound-Guided Extrafascial Versus Intrafascial Interscalene Brachial Plexus Block in Shoulder Arthroscopy
- First Posted Date
- 2022-02-03
- Last Posted Date
- 2022-02-03
- Lead Sponsor
- Tanta University
- Target Recruit Count
- 50
- Registration Number
- NCT05222334
The Effect of Caudal Block on Optic Nerve Sheath Diameter in Pediatric Patients
- Conditions
- Interventions
- First Posted Date
- 2022-01-31
- Last Posted Date
- 2022-12-23
- Lead Sponsor
- Ataturk University
- Target Recruit Count
- 60
- Registration Number
- NCT05216211
- Locations
- 🇹🇷
Ataturk University School of Medicine, Erzurum, Yakutiye, Turkey
Dexamethasone & Ketamine as Adjuvants to Bupivacaine for Incisional Infiltration in Pediatric Abdominal Operations
- Conditions
- Interventions
- First Posted Date
- 2022-01-13
- Last Posted Date
- 2022-01-13
- Lead Sponsor
- Ain Shams University
- Target Recruit Count
- 150
- Registration Number
- NCT05190952
- Locations
- 🇪🇬
Ain Shams university hospitals, Cairo, Al Abbassia, Egypt
Postoperative Pain Control by Use of Many Drugs in Small Doses Intrathecally
- Conditions
- Interventions
- First Posted Date
- 2022-01-11
- Last Posted Date
- 2022-01-28
- Lead Sponsor
- Sohag University
- Target Recruit Count
- 60
- Registration Number
- NCT05186454
- Locations
- 🇪🇬
Fouad Soliman, Sohag, Egypt
Post-operative Pain Control-TAP Block Using Exparel vs. Marcaine for Hernia Repairs
- Conditions
- Interventions
- First Posted Date
- 2022-01-05
- Last Posted Date
- 2023-10-31
- Lead Sponsor
- Leslie Son
- Target Recruit Count
- 200
- Registration Number
- NCT05177991
- Locations
- 🇺🇸
Karl LeBlanc, Baton Rouge, Louisiana, United States
The Use of Pecs Blocks in Combination With Exparel in Breast Reconstruction Surgery
- Conditions
- Interventions
- First Posted Date
- 2021-12-28
- Last Posted Date
- 2023-11-09
- Lead Sponsor
- Northwestern University
- Target Recruit Count
- 90
- Registration Number
- NCT05171179
- Locations
- 🇺🇸
Northwestern Memorial Hospital, Chicago, Illinois, United States
Phase 3, Sciatic Nerve Block With EXPAREL for Subjects Undergoing Bunionectomy
- Conditions
- Interventions
- First Posted Date
- 2021-12-15
- Last Posted Date
- 2022-09-08
- Lead Sponsor
- Pacira Pharmaceuticals, Inc
- Target Recruit Count
- 185
- Registration Number
- NCT05157841
- Locations
- 🇺🇸
Lotus Clinical Research, Pasadena, California, United States
🇺🇸Midwest Clinical Research Center, Dayton, Ohio, United States
🇺🇸HD Research- First Surgical Hospital, Bellaire, Texas, United States
Phase 3 Adductor Canal Block With EXPAREL in Subjects Undergoing Primary Unilateral Total Knee Arthroplasty
- Conditions
- Interventions
- First Posted Date
- 2021-12-01
- Last Posted Date
- 2024-10-24
- Lead Sponsor
- Pacira Pharmaceuticals, Inc
- Target Recruit Count
- 167
- Registration Number
- NCT05139030
- Locations
- 🇺🇸
Woodland International Research Group, Little Rock, Arkansas, United States
🇺🇸Endeavor Clinical Trials, San Antonio, Texas, United States
🇺🇸Lotus Clinical Research, Pasadena, California, United States
Low-Doses Of Isobaric Bupivacaine On Intraoperative Hemodynamics In Spinal Anesthesia During Cesarean Section
- Conditions
- Interventions
- First Posted Date
- 2021-11-26
- Last Posted Date
- 2021-12-08
- Lead Sponsor
- Ataturk University
- Target Recruit Count
- 80
- Registration Number
- NCT05136040
- Locations
- 🇹🇷
Aysenur Dostbil, Yakutiye, Erzurum, Turkey
The Hemodynamic Effects of Different Volumes of Bupivacaine 0.25% Caudal Blocks in Pediatrics Undergoing Lower Abdominal Surgeries as Measured by Electrical Cardiometry
- First Posted Date
- 2021-11-24
- Last Posted Date
- 2024-07-09
- Lead Sponsor
- Kasr El Aini Hospital
- Target Recruit Count
- 105
- Registration Number
- NCT05133687
- Locations
- 🇪🇬
Cairo university hospitals, kasralainy, Cairo, Egypt
Drug Development Updates
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