Evinacumab is a recombinant human IgG4 monoclonal antibody targeted against angiopoietin-like protein 3 (ANGPTL3) and the first drug of its kind. The ANGPTL family of proteins serve a number of physiologic functions - including involvement in the regulation of lipid metabolism - which have made them desirable therapeutic targets in recent years. Loss-of-function mutations in ANGPTL3 have been noted to result in hypolipidemia and subsequent reductions in cardiovascular risk, whereas increases in function appear to be associated with cardiovascular risk, and it was these observations that provided a rationale for the development of a therapy targeted against ANGPTL3.
In February 2021, evinacumab became the first-and-only inhibitor of ANGPTL3 to receive FDA approval after it was granted approval for the adjunctive treatment of homozygous familial hypercholesterolemia (HoFH) under the brand name "Evkeeza". Evinacumab is novel in its mechanism of action compared with other lipid-lowering therapies and therefore provides a unique and synergistic therapeutic option in the treatment of HoFH.
Evinacumab is indicated, as an adjunct with other lipid-lowering therapies, for the treatment of familial homozygous hypercholesterolemia (HoFH) in patients 5 years of age and older.
Ecogene-21, Saguenay, Quebec, Canada
Saint Louis University, Saint Louis, Missouri, United States
Clinique des maladies lipidiques de Quebec, Quebec, Canada
Excel Medical Clinical Trials, LLC, Boca Raton, Florida, United States
Regeneron Research Center, Taipei, Taiwan
Regeneron Research Site, Kyiv, Ukraine
Regeneron Research Facility, Manchester, United Kingdom
Clinical Trial Site #2, Kharkiv, Ukraine
Clinical Trial Site, Kyiv, Ukraine
Regeneron Study Site, Cape Town, Western Cape, South Africa
Regeneron Research Site #2, Kyiv, Ukraine
Regeneron Research Site, Kyiv, Ukraine
Regeneron Research Site # 2, Napoli, Italy
Azienda Ospedaliero Universitaria Federico II di Napoli, Napoli, Italy
Dipartimento di Medicina Traslazionale e di Precisione dell'Università degli Studi di, Rome, Italy
Office of Dr. John D Homan MD, Newport Beach, California, United States
WCCT Global, Inc., Cypress, California, United States
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