Odevixibat, or A4250, is an ileal sodium/bile acid cotransporter inhibitor indicated for the treatment of pruritus in patients older than 3 months, with progressive familiar intrahepatic cholestasis (PFIC). Odevixibat is the first approved non-surgical treatment option for PFIC. Previous therapies for PFIC included a bile acid sequestrant such as ursodeoxych...
Odevixibat is indicated for the treatment of pruritus in patients older than 3 months with progressive familiar intrahepatic cholestasis (PFIC) and cholestatic pruritus in patients 12 months of age and older with Alagille Syndrome. It may not be effective in patients with PFIC type 2 with ABCB11 variants since these patients lack a functional bile salt expor...
Boston Children's Hospital, Boston, Massachusetts, United States
Indiana University school of Medicine, Indianapolis, Indiana, United States
Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, United States
Texas Liver Institute, San Antonio, Texas, United States
UCSF, San Francisco, California, United States
University of California San Francisco (UCSF), San Francisco, California, United States
Antenne pédiatrique du CIC - Hopital Jeanne De Flandre, Lille, France
Hopital Necker Enfants Malades, Paris, France
Istanbul University Medical Faculty Hospital, Fatih, Turkey
Albireo Pharma Inc., Boston, Massachusetts, United States
Children's Healthcare of Atlanta - Emory University School of Medicine, Atlanta, Georgia, United States
Johns Hopkins Children's Center, Baltimore, Maryland, United States
Seattle Children's Hospital, Seattle, Washington, United States
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