Pentoxifylline
- Generic Name
- Pentoxifylline
- Brand Names
- -
- Drug Type
- Small Molecule
- Chemical Formula
- C13H18N4O3
- CAS Number
- 6493-05-6
- Unique Ingredient Identifier
- SD6QCT3TSU
- Background
Pentoxifylline (PTX) is a synthetic dimethylxanthine derivative that modulates the rheological properties of blood and also has both anti-oxidant and anti-inflammatory properties. Although originally developed to treat intermittent claudication, a form of exertion-induced leg pain common in patients with peripheral arterial disease, PTX has been investigated...
- Indication
Pentoxifylline is indicated for the treatment of intermittent claudication in patients with chronic occlusive arterial disease. Pentoxifylline may improve limb function and reduce symptoms but cannot replace other therapies such as surgical bypass or removal of vascular obstructions.
- Associated Conditions
- Intermittent Claudication, Venous Leg Ulcer (VLU), Severe alcoholic liver disease
- Associated Therapies
- -
Pentoxifylline Effect in Patients With Diabetic Nephropathy.(PENFOSIDINE STUDY)
- Conditions
- Interventions
- First Posted Date
- 2018-09-10
- Last Posted Date
- 2019-02-07
- Lead Sponsor
- Maria Eugenia Galván Plata
- Target Recruit Count
- 196
- Registration Number
- NCT03664414
- Locations
- 🇲🇽
Cibimi - Hgz 83 Imss, Morelia, Michoacán, Mexico
Pentoxifylline in Diabetic Kidney Disease
- First Posted Date
- 2018-08-10
- Last Posted Date
- 2024-11-19
- Lead Sponsor
- VA Office of Research and Development
- Target Recruit Count
- 2510
- Registration Number
- NCT03625648
- Locations
- 🇺🇸
James A. Haley Veterans' Hospital, Tampa, FL, Tampa, Florida, United States
🇺🇸Atlanta VA Medical and Rehab Center, Decatur, GA, Decatur, Georgia, United States
🇺🇸Edward Hines Jr. VA Hospital, Hines, IL, Hines, Illinois, United States
Effects of Pentoxifylline and Vitamin E on Pregnancy Rate in Infertile Women Treated by ICSI:
- First Posted Date
- 2018-03-26
- Last Posted Date
- 2018-03-26
- Lead Sponsor
- Benha University
- Target Recruit Count
- 140
- Registration Number
- NCT03476564
- Locations
- 🇪🇬
El Galaa Teaching hosptial, Cairo, Ghamra, Egypt
Erectile Recovery After Robotic-Assisted Laparoscopic Prostatectomy
- Conditions
- Interventions
- First Posted Date
- 2018-01-23
- Last Posted Date
- 2018-01-23
- Lead Sponsor
- Brooke Army Medical Center
- Target Recruit Count
- 180
- Registration Number
- NCT03406169
- Locations
- 🇺🇸
Brooke Army Medical Center, San Antonio, Texas, United States
Pentoxifylline and Tocopherol (PENTO) in the Treatment of Medication-related Osteonecrosis of the Jaw (MRONJ)
- First Posted Date
- 2017-02-02
- Last Posted Date
- 2024-05-31
- Lead Sponsor
- University of Washington
- Target Recruit Count
- 100
- Registration Number
- NCT03040778
- Locations
- 🇺🇸
University of Alabama at Birmingham, Birmingham, Alabama, United States
🇺🇸University of Washington, Seattle, Washington, United States
🇺🇸New York Center for Orthognathic and Maxillofacial Surgery, Lake Success, New York, United States
Add-on Pentoxifylline to Losartan Versus Increasing Dose of Losartan on NT-PRO BNP in Type 2 Diabetics With Nephropathy
- First Posted Date
- 2016-12-30
- Last Posted Date
- 2016-12-30
- Lead Sponsor
- Tehran University of Medical Sciences
- Target Recruit Count
- 59
- Registration Number
- NCT03006952
- Locations
- 🇮🇷
Tehran University of Medical Sciences, Tehran, Iran, Islamic Republic of
Pentoxifylline for the Prevention of PEP
- First Posted Date
- 2016-12-14
- Last Posted Date
- 2016-12-14
- Lead Sponsor
- Anhui Provincial Hospital
- Target Recruit Count
- 110
- Registration Number
- NCT02992678
- Locations
- 🇨🇳
Department of General Surgery, Anhui Provincial Hospital Affiliated with Anhui Medical University, HeFei, Anhui, China
Synergistic Effect of Vedolizumab and Pentoxifylline
- Conditions
- Interventions
- First Posted Date
- 2016-11-02
- Last Posted Date
- 2019-07-11
- Lead Sponsor
- University of Miami
- Target Recruit Count
- 37
- Registration Number
- NCT02953275
- Locations
- 🇺🇸
University of Miami Crohn's and Colitis Center, Miami, Florida, United States
Clinical Benefit of Spa Care on Severe Radiation-induced Fibrosis After Postoperative Radiotherapy for Breast Cancer
- Conditions
- Interventions
- First Posted Date
- 2016-09-13
- Last Posted Date
- 2018-08-08
- Lead Sponsor
- Institut de Cancérologie de Lorraine
- Target Recruit Count
- 142
- Registration Number
- NCT02898376
- Locations
- 🇫🇷
Hôpitaux Civils de Colmar, Colmar, France
🇫🇷Institut Daniel Hollard, Grenoble, France
🇫🇷CLCC Saint Etienne, Saint-Priest en Jarez, France
Meta-Analysis of Drug Therapy in Patients With Severe Alcoholic Hepatitis
- Conditions
- Interventions
- First Posted Date
- 2016-06-10
- Last Posted Date
- 2016-06-10
- Lead Sponsor
- University Hospital, Lille
- Target Recruit Count
- 1974
- Registration Number
- NCT02796469
Drug Development Updates
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