MedPath

Riboflavin

Generic Name
Riboflavin
Brand Names
Alertonic, Concept Ob, Irospan 24/6 Kit, Mvc-fluoride, Natafort, Pregvit, Tandem Plus, Vitafol-one
Drug Type
Small Molecule
Chemical Formula
C17H20N4O6
CAS Number
83-88-5
Unique Ingredient Identifier
TLM2976OFR

Overview

Nutritional factor found in milk, eggs, malted barley, liver, kidney, heart, and leafy vegetables. The richest natural source is yeast. It occurs in the free form only in the retina of the eye, in whey, and in urine; its principal forms in tissues and cells are as flavin mononucleotide and flavin-adenine dinucleotide.

Background

Nutritional factor found in milk, eggs, malted barley, liver, kidney, heart, and leafy vegetables. The richest natural source is yeast. It occurs in the free form only in the retina of the eye, in whey, and in urine; its principal forms in tissues and cells are as flavin mononucleotide and flavin-adenine dinucleotide.

Indication

For the treatment of ariboflavinosis (vitamin B2 deficiency).

Associated Conditions

  • Ariboflavinosis
  • Beriberi
  • Constipation
  • Functional Gastrointestinal Disorders (FGID)
  • Joint Pain
  • Metabolic cardiomyopathy
  • Migraine
  • Myalgia
  • Neuropathic Pain
  • Peripheral neuritis
  • Peripheral paralysis
  • Vitamin B complex deficiency
  • Vitamin B1 deficiency
  • Vitamin Deficiency
  • Wernicke's encephalopathy

FDA Drug Approvals

Approved Product
Manufacturer
NDC Code
Route
Strength
Effective Date
AvPAK
50268-677
ORAL
3 mg in 1 1
4/12/2022
CarWin Pharmaceutical Associates, LLC
15370-105
ORAL
1.3 mg in 1 1
1/10/2024
Method Pharmaceuticals, LLC
58657-164
ORAL
1.2 mg in 1 1
12/9/2023
Exeltis USA, Inc.
0642-7473
ORAL
1.8 mg in 1 1
2/14/2023
Marnel Pharmaceuticals, Inc.
0682-3001
ORAL
20 mg in 1 1
5/2/2014
Centurion Labs, LLC
23359-105
ORAL
3 mg in 1 1
1/22/2024
PureTek Corporation
59088-193
ORAL
3.4 mg in 1 1
1/11/2023
BonGeo Pharmaceuticals, Inc.
52796-174
ORAL
1.5 mg in 1 1
2/2/2024
Cameron Pharmaceuticals
42494-432
ORAL
1.2 mg in 1 1
9/18/2023
Carilion Materials Management
68151-2640
ORAL
3 mg in 1 1
4/1/2013

EMA Drug Approvals

Approved Product
Authorization Holder
Status
Issued Date
No EMA approvals found for this drug.

HSA Drug Approvals

Approved Product
Manufacturer
Approval Number
Dosage Form
Strength
Approval Date
ENZYPLEX TABLET
SIN06211P
ENTERIC COATED TABLET
5 mg
5/3/1991
IBERET-FOLIC-500 TABLET
SIN05447P
TABLET, FILM COATED
6 mg
2/19/1991
FBC FILMTAB
SIN05814P
TABLET, FILM COATED
2 mg
5/3/1991
CERNEVIT FOR INJECTION
SIN11975P
INJECTION, POWDER, FOR SOLUTION
4.14 mg/vial
6/5/2002

NMPA Drug Approvals

Approved Product
Company
Approval Number
Drug Type
Dosage Form
Approval Date
Vitamin B2 Tablets
国药准字H12020169
化学药品
片剂
8/13/2020
Vitamin B2 Tablets
国药准字H22020790
化学药品
片剂
10/10/2020
Vitamin B2 Tablets
国药准字H46020369
化学药品
片剂
3/26/2020
Vitamin B2 Tablets
国药准字H44022759
化学药品
片剂
1/11/2021
Vitamin B2 Tablets
国药准字H14022479
化学药品
片剂
8/18/2020
Vitamin B2 Tablets
国药准字H61022321
化学药品
片剂
7/14/2022
Vitamin B2 Tablets
国药准字H36021088
化学药品
片剂
7/14/2021
Vitamin B2 Tablets
国药准字H34021622
化学药品
片剂
6/2/2020
Vitamin B2 Tablets
国药准字H61020800
化学药品
片剂
5/28/2020
Vitamin B2 Tablets
国药准字H44021854
化学药品
片剂
11/27/2020

PPB Drug Approvals

Approved Product
Registration No.
Company
Licence No.
Strength
Registration Date
MULTIMAX SYRUP
N/A
vickmans laboratories ltd
N/A
N/A
7/8/2014
CERNEVIT FOR INJ
N/A
N/A
N/A
4/18/2008
BIOCATALIN INJECTABLE SOLN (VET)
N/A
wai lung hong agribusiness ltd
N/A
N/A
8/9/1984
CHLORAFORTE CAP
N/A
meyer pharmaceuticals ltd
N/A
N/A
6/2/1992
BIHAKU TAB
N/A
sato pharmaceutical (hk) co ltd
N/A
N/A
7/1/1994
BOGEN-50 S C TAB
N/A
wilcome pharmaceutical co ltd
N/A
N/A
4/28/1982
HUAZIN INJ
N/A
wilcome pharmaceutical co ltd
N/A
N/A
4/28/1982

TGA Drug Approvals

Approved Product
ARTG ID
Sponsor
Registration Type
Status
Registration Date
Energy Multi
453128
Medicine
A
6/21/2024
Cellula-T oral powder jar
43995
Hong Sp & Hs
Medicine
A
4/13/1993
Men's Multi
326959
Medicine
A
12/2/2019
Super B Complex tablets
126510
Medicine
A
3/28/2006
BLACKMORES SUPERKIDS MULTI CHEWABLES
289492
Medicine
A
5/30/2017
BLACKMORES B+C TABLETS
215811
Medicine
A
10/9/2013
Wealthy Health Bio-Maxi B Excellent Stress Relief Formula with Herbs
139048
Medicine
A
5/21/2007
Caruso's Hair Food
130857
Medicine
A
8/30/2006
MaxN-Fuze Multivitamins
288444
Max Health & Living Australia Pty Ltd
Medicine
A
5/1/2017
Berocca Performance Original effervescent tablets
193893
Medicine
A
1/17/2012
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