Riboflavin
- Generic Name
- Riboflavin
- Brand Names
- Alertonic, Concept Ob, Irospan 24/6 Kit, Mvc-fluoride, Natafort, Pregvit, Tandem Plus, Vitafol-one
- Drug Type
- Small Molecule
- Chemical Formula
- C17H20N4O6
- CAS Number
- 83-88-5
- Unique Ingredient Identifier
- TLM2976OFR
- Background
Nutritional factor found in milk, eggs, malted barley, liver, kidney, heart, and leafy vegetables. The richest natural source is yeast. It occurs in the free form only in the retina of the eye, in whey, and in urine; its principal forms in tissues and cells are as flavin mononucleotide and flavin-adenine dinucleotide.
- Indication
For the treatment of ariboflavinosis (vitamin B2 deficiency).
- Associated Conditions
- Ariboflavinosis, Beriberi, Constipation, Functional Gastrointestinal Disorders (FGID), Joint Pain, Metabolic cardiomyopathy, Migraine, Myalgia, Neuropathic Pain, Peripheral neuritis, Peripheral paralysis, Vitamin B complex deficiency, Vitamin B1 deficiency, Vitamin Deficiency, Wernicke's encephalopathy
- Associated Therapies
- Dietary and Nutritional Therapies, Nutritional supplementation, Vitamin supplementation, Dietary supplementation
Treatment of Keratoconus With Advanced CXL-II
- Conditions
- Keratoconus
- Interventions
- Procedure: Topography-based CXL (KXL2)Procedure: Conventional pulsed CXL (pCXL)Drug: RiboflavinDevice: Avedro KXL II
- First Posted Date
- 2015-08-03
- Last Posted Date
- 2018-05-16
- Lead Sponsor
- Umeå University
- Target Recruit Count
- 50
- Registration Number
- NCT02514200
Evaluation of a Compliance Marker in Prescription Opioid Abusers With Chronic Pain
- Conditions
- ComplianceChronic Pain
- Interventions
- First Posted Date
- 2014-10-28
- Last Posted Date
- 2017-02-10
- Lead Sponsor
- Georgetown University
- Registration Number
- NCT02276989
- Locations
- 🇺🇸
Georgetown University, Washington, District of Columbia, United States
The Effects of mETHotrexate Therapy on ST Segment Elevation MYocardial InfarctionS (TETHYS Trial)
- First Posted Date
- 2012-12-05
- Last Posted Date
- 2013-04-09
- Lead Sponsor
- Instituto de Cardiologia do Rio Grande do Sul
- Target Recruit Count
- 80
- Registration Number
- NCT01741558
- Locations
- 🇧🇷
Instituto de Cardiologia do Rio Grande do Sul / Fundação Universitária de Cardiologia, Porto Alegre, Rio Grande do Sul, Brazil
🇧🇷Instituto de Cardiologia de Santa Catarina, São José, Santa Catarina, Brazil
Combined CXL//UV and PRK or LASIK in Forme Fruste Keratoconus or Eyes With Potential Risk of Ectasia
- Conditions
- Fruste KeratoconusRisk of Ectasia
- Interventions
- Device: Corneal Cross-LinkingDrug: Riboflavin
- First Posted Date
- 2012-11-14
- Last Posted Date
- 2015-08-24
- Lead Sponsor
- Cxlusa
- Target Recruit Count
- 22
- Registration Number
- NCT01726283
- Locations
- 🇺🇸
Talamo Laser Eye Center, Waltham, Massachusetts, United States
🇺🇸Schwartz Laser Eye Center, Scottsdale, Arizona, United States
🇺🇸Cleveland Eye Clinic, Breckville, Ohio, United States
Use of Cross-linked Donor Corneas as Carriers for the Boston Keratoprosthesis
- Conditions
- Chemical InjuriesAutoimmune DiseasesOcular Cicatricial PemphigoidStevens Johnson SyndromeOther Autoimmune DiseasesUnspecified Complication of Corneal TransplantLupus Erythematosus, SystemicRheumatoid Arthritis
- Interventions
- First Posted Date
- 2012-04-23
- Last Posted Date
- 2019-10-21
- Lead Sponsor
- Joseph B. Ciolino, MD
- Target Recruit Count
- 1
- Registration Number
- NCT01582880
- Locations
- 🇺🇸
Massachusetts Eye and Ear Infirmary, Boston, Massachusetts, United States
Transepithelial Corneal Collagen Crosslinking for Keratoconus and Corneal Ectasia
- First Posted Date
- 2011-11-03
- Last Posted Date
- 2023-02-08
- Lead Sponsor
- Cornea and Laser Eye Institute
- Target Recruit Count
- 160
- Registration Number
- NCT01464268
- Locations
- 🇺🇸
Cornea and Laser Eye Institute, Teaneck, New Jersey, United States
Safety Study of the VEGA UV-A System to Treat Ectasia
- Conditions
- Ectasia
- Interventions
- Device: VEGA UV-A Illumination SystemDrug: Riboflavin
- First Posted Date
- 2011-07-21
- Last Posted Date
- 2022-06-29
- Lead Sponsor
- Topcon Medical Systems, Inc.
- Target Recruit Count
- 103
- Registration Number
- NCT01398839
- Locations
- 🇺🇸
Barnet Dulaney Perkins Eye Center, Phoenix, Arizona, United States
🇺🇸Slade & Baker Vision, Houston, Texas, United States
🇺🇸The Eye Institute of Utah, Salt Lake City, Utah, United States
Safety and Effectiveness Study of the VEGA UV-A System for Cross-linking in Eyes With Keratoconus and Ectasia
- Conditions
- Keratoconus and Ectasia
- Interventions
- Drug: RiboflavinDevice: VEGA UV-A Illumination System
- First Posted Date
- 2011-07-21
- Last Posted Date
- 2022-06-29
- Lead Sponsor
- Topcon Medical Systems, Inc.
- Target Recruit Count
- 500
- Registration Number
- NCT01398852
- Locations
- 🇺🇸
Woolfson Eye Institute, Atlanta, Georgia, United States
🇺🇸ReVision Advanced Laser Eye Center, Columbus, Ohio, United States
🇺🇸OSU Department of Ophthalomogy, Columbus, Ohio, United States
UVA-Riboflavin Crosslinking Treatment of Corneal Ectasia
- First Posted Date
- 2011-03-29
- Last Posted Date
- 2011-03-29
- Lead Sponsor
- Mercy Center for Corrective Eye Surgery
- Target Recruit Count
- 250
- Registration Number
- NCT01325298
- Locations
- 🇺🇸
Mercy Center for Corrective Eye Surgery, McHenry, Illinois, United States
Riboflavin Corneal Crosslinking for Brittle Cornea Syndrome and Ehlers-Danlos Syndrome Type VI
- Conditions
- Brittle Cornea SyndromeEhlers-Danlos Syndrome Type 6
- First Posted Date
- 2011-03-03
- Last Posted Date
- 2011-03-03
- Lead Sponsor
- Hadassah Medical Organization
- Target Recruit Count
- 1
- Registration Number
- NCT01307527
- Locations
- 🇮🇱
Hadassah Medical Organization, Jerusalem, Israel
Drug Development Updates
Stay informed with timely notifications on clinical trials, regulatory changes, and research advancements related to this medication.