Amiloride
- Generic Name
- Amiloride
- Brand Names
- Midamor
- Drug Type
- Small Molecule
- Chemical Formula
- C6H8ClN7O
- CAS Number
- 2609-46-3
- Unique Ingredient Identifier
- 7DZO8EB0Z3
- Background
A pyrazine compound inhibiting sodium reabsorption through sodium channels in renal epithelial cells. This inhibition creates a negative potential in the luminal membranes of principal cells, located in the distal convoluted tubule and collecting duct. Negative potential reduces secretion of potassium and hydrogen ions. Amiloride is used in conjunction with ...
- Indication
For use as adjunctive treatment with thiazide diuretics or other kaliuretic-diuretic agents in congestive heart failure or hypertension.
- Associated Conditions
- Ascites, Calcium Nephrolithiasis, Congestive Heart Failure (CHF), Hypertension, Hypokalemia, Metabolic Alkalosis, Polyuria
- Associated Therapies
- -
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