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Chlorquinaldol

Generic Name
Chlorquinaldol
Drug Type
Small Molecule
Chemical Formula
C10H7Cl2NO
CAS Number
72-80-0
Unique Ingredient Identifier
D6VHC87LLS

Overview

Chlorquinaldol was used historically as a topical antiseptic under the trade name Sterosan. It was marketed in the 1950s as an iodine-free alternative which was also unrelated to sulfa drugs or hormones. Chlorquinaldol is currently approved by the European Medicines Agency as a combination tablet with promestriene for the treatment of bacterial vaginosis.

Indication

Chlorquinaldol was used historically as a topical antiseptic agent for skin infections. It maintains use in European countries as a combination vaginal tablet with promestriene for use in the treatment of vaginal infections.

Associated Conditions

  • Allergic Skin Reaction
  • Dermatitis
  • Fungal skin infection
  • Skin Infections
  • Vaginal atrophy with infection

Research Report

Published: May 16, 2025

Chlorquinaldol Report

Name: Chlorquinaldol Name (English): Chlorquinaldol DrugBank ID: DB13306 Type: Small Molecule CAS Number: 72-80-0

Synonyms: 2-methyl-5,7-dichloro-8-hydroxyquinoline, 5,7-dichloro-2-methyl-8-hydroxyquinoline, 5,7-dichloro-2-methyl-8-quinolinol, 5,7-dichloro-8-hydroxy-2-methylquinoline, 5,7-dichloro-8-hydroxyquinaldine, 5,7-dichloro-8-quinaldinol, Chlorchinaldol, Chlorquinaldolum, Chloquinan, Chlorchinaldin, Chlorguinaldon, Chloroquinaldol, Florabina, Gyno-Sterosan, Hydroxydichloroquinaldine, Intensol, Saprosan, Siogen, Siogenal, Siogene, Siogeno, Siogenon, Siosept, Siosteran, Sterosan, Steroxin, Sterozan, Vagisteran, 5,7-dichloro-2-methylquinolin-8-ol.

Pharmacology:

  • Indication: Historically used as a topical antiseptic agent for skin infections. Currently used in European countries as a combination vaginal tablet with promestriene for the treatment of vaginal infections. Also used for skin, gastrointestinal, and vaginal infections with fungi, protozoa, and certain bacteria. Used in combination to treat vaginal atrophy with infection and for symptomatic treatment of allergic skin manifestations, and prophylaxis and treatment of mycotic skin infection (in combination with difluocortolone).
  • Mechanism of Action: Bactericidal against both gram-positive and gram-negative bacteria, more effective against gram-positive bacteria, particularly staphylococci. The exact mechanism of its bactericidal effect is unknown, but 8-hydroxyquinolines are known to be bidentate chelators of several metal ions which act as critical enzyme cofactors. Does not appear to rely on chelation as the primary mechanism. Disrupts the cell membranes of bacteria and fungi and may interfere with their DNA replication processes. Exhibits anti-inflammatory properties.
  • Pharmacodynamics: Bactericidal effect against various microorganisms.
  • Absorption: Variable absorption (4.2 to 23.5%) after topical application. Oral absorption i

Continue reading the full research report

Clinical Trials

Title
Posted
Study ID
Phase
Status
Sponsor
2010/06/30
Phase 4
Terminated

FDA Drug Approvals

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No FDA approvals found for this drug.

EMA Drug Approvals

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No EMA approvals found for this drug.

HSA Drug Approvals

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No HSA approvals found for this drug.

NMPA Drug Approvals

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No NMPA approvals found for this drug.

PPB Drug Approvals

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No PPB approvals found for this drug.

TGA Drug Approvals

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No TGA approvals found for this drug.

Health Canada Drug Approvals

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No Health Canada approvals found for this drug.

CIMA AEMPS Drug Approvals

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No CIMA AEMPS (Spain) approvals found for this drug.

Philippines FDA Drug Approvals

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No Philippines FDA approvals found for this drug.

Saudi SFDA Drug Approvals

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No Saudi SFDA approvals found for this drug.

Malaysia NPRA Drug Approvals

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No Malaysia NPRA approvals found for this drug.

UK EMC Drug Information

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No UK EMC drug information found for this drug.

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