MedPath

Denenicokin

Generic Name
Denenicokin
Drug Type
Biotech
CAS Number
716840-32-3
Unique Ingredient Identifier
A4LY1V9F0H
Background

Denenicokin is under investigation in clinical trial NCT01152788 (Phase II Study of Interleukin-21 (rIL-21) vs Dacarbazine (DTIC) in Patients With Metastatic or Recurrent Melanoma).

FDA Approves ORLYNVAH™: First New Oral Treatment for Uncomplicated UTIs in 25 Years

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Itolizumab Shows Promising Results in Phase 2 Ulcerative Colitis Trial, Matching Adalimumab Efficacy

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Werewolf Therapeutics Announces 2025 Milestones for IL-2 and IL-12 INDUKINE Programs

• Werewolf Therapeutics anticipates sharing preliminary monotherapy data for WTX-124 in H1 2025, potentially guiding regulatory engagement for accelerated approval. • A Phase 1/2 clinical trial of WTX-330, an IL-12 INDUKINE molecule, is expected to begin in Q1 2025, targeting immunotherapy-resistant cancers. • Interim data from combination expansion arms of WTX-124 with pembrolizumab are expected in Q4 2025, further evaluating its efficacy in solid tumors. • Werewolf's cash position is expected to fund operations through at least the second quarter of 2026, supporting ongoing clinical development.

Vivtex and Equillium Collaborate on Oral Biologic for GI Inflammation

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Allogeneic NK Cell Therapy Shows Promise in Relapsed Neuroblastoma: Phase I Trial Results

• A Phase I clinical trial evaluated the safety and efficacy of allogeneic natural killer (NK) cell therapy in children with relapsed or refractory neuroblastoma. • The study demonstrated that NK cell therapy is safe and feasible, with no dose-limiting toxicities observed across the tested dose range. • Preliminary efficacy signals were observed, including stable disease in some patients, warranting further investigation in larger trials. • This approach offers a potential new treatment option for high-risk neuroblastoma, addressing the need for more effective therapies.
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