Aminolevulinic Acid
- Generic Name
- Aminolevulinic Acid
- Brand Names
- Ameluz, Gliolan, Levulan
- Drug Type
- Small Molecule
- Chemical Formula
- C5H9NO3
- CAS Number
- 106-60-5
- Unique Ingredient Identifier
- 88755TAZ87
- Background
A compound produced from succinyl-CoA and glycine as an intermediate in heme synthesis. It is used as a photochemotherapy for actinic keratosis. [PubChem]
- Indication
用于皮肤癌及鲍温病、牛皮癣，男性尿道尖锐湿疣等皮肤病。可治疗消化道肿瘤、口腔癌。可诊断和治疗膀胱癌、尿路上皮肿瘤。能阻止血管成形术后在狭窄。
- Associated Conditions
- Actinic Cheilitis, Actinic Keratoses of the face, Actinic Keratoses of the scalp, Actinic Keratosis (AK) of the Upper Extremity, Basal Cell Carcinoma (BCC), Cutaneous Squamous Cell Carcinoma in Situ (CSCCis), Glioma
- Associated Therapies
- -
TRK Inhibitor Active in Treatment-Refractory Glioblastoma
27% of patients with TRK fusion primary central nervous system tumors responded to the TRK inhibitor larotrectinib, with 37% of pediatric patients responding. The drug showed a manageable safety profile and supported the use of next-generation sequencing panels for CNS tumors. Additionally, an investigational ATM pathway inhibitor demonstrated preliminary activity in combination with radiotherapy for glioblastoma, and a novel sonodynamic therapy device showed promising results in recurrent high-grade glioma patients.
Alpheus Medical Announces Positive Phase 1/2 Trial Results for the Treatment of Recurrent High-Grade Gliomas
Alpheus Medical announced positive Phase 1/2 trial results for sonodynamic therapy (SDT) in treating recurrent high-grade gliomas, showing extended median overall survival (OS) and progression-free survival (PFS) with a strong safety profile. The therapy combines low-intensity diffuse ultrasound (LIDU™) with oral 5-aminolevulinic acid (5-ALA) and is non-invasive, delivered in an outpatient setting.
Related Clinical Trials:
Drug Development Updates
Stay informed with timely notifications on clinical trials, regulatory changes, and research advancements related to this medication.
© Copyright 2024. All Rights Reserved by MedPath