Aminolevulinic Acid

Generic Name: Aminolevulinic Acid

Brand Names: Ameluz, Gliolan, Levulan

Drug Type: Small Molecule

Chemical Formula: C_₅H_₉NO_₃

CAS Number: 106-60-5

Unique Ingredient Identifier: 88755TAZ87

Background: A compound produced from succinyl-CoA and glycine as an intermediate in heme synthesis. It is used as a photochemotherapy for actinic keratosis. [PubChem]

Indication: 用于皮肤癌及鲍温病、牛皮癣，男性尿道尖锐湿疣等皮肤病。可治疗消化道肿瘤、口腔癌。可诊断和治疗膀胱癌、尿路上皮肿瘤。能阻止血管成形术后在狭窄。

Associated Conditions: Actinic Cheilitis, Actinic Keratoses of the face, Actinic Keratoses of the scalp, Actinic Keratosis (AK) of the Upper Extremity, Basal Cell Carcinoma (BCC), Cutaneous Squamous Cell Carcinoma in Situ (CSCCis), Glioma

Associated Therapies: -

Clinical Trials

A Study of Aminolevulinic Acid Used to Enhance Visualization and Surgical Removal of Brain Tumors

Phase 2

Terminated

Conditions: Glioma
Glioblastoma
Glioblastoma Multiforme
Malignant Glioma
Astrocytoma

Interventions: Drug: Aminolevulinic Acid

First Posted Date: 2011-05-11

Last Posted Date: 2016-03-17

Lead Sponsor: MultiCare Health System Research Institute

Target Recruit Count: 16

Registration Number: NCT01351519

Locations: 🇺🇸
MultiCare Health System Research Institute, Tacoma, Washington, United States

Gliadel Wafer and Fluorescence-Guided Surgery With 5-ALA Followed by Radiation Therapy And Temozolomide in Treating Patients With Primary Glioblastoma

Phase 2

Completed

Conditions: Glioblastoma

Interventions: Drug: 5-ALA
Drug: Gliadel wafers
Radiation: Radiotherapy as normal based on standard clinical protocols determined by the neuro-oncologist
Drug: Concomitant chemotherapy as normal based on standard clinical protocols determined by the neuro-oncologist
Drug: Adjuvant chemotherapy as normal based on standard clinical protocols determined by the neuro-oncologist

First Posted Date: 2011-03-09

Last Posted Date: 2017-10-05

Lead Sponsor: University College, London

Target Recruit Count: 59

Registration Number: NCT01310868

Locations: 🇬🇧
Royal Preston Hospital, Preston, Lancashire, United Kingdom
🇬🇧
Leeds General Infirmary, Leeds, United Kingdom
🇬🇧
Ninewells Hospital, Dundee, United Kingdom

and more 7 locations

Aminolevulinic Acid During Surgery in Treating Patients With Malignant Brain Tumors

Phase 1

Terminated

Conditions: Adult Anaplastic Oligodendroglioma
Adult Mixed Glioma
Recurrent Adult Brain Tumor
Adult Glioblastoma
Adult Anaplastic Astrocytoma
Adult Giant Cell Glioblastoma
Adult Gliosarcoma

Interventions: Drug: aminolevulinic acid
Other: laboratory biomarker analysis
Procedure: therapeutic conventional surgery

First Posted Date: 2010-06-23

Last Posted Date: 2017-02-15

Lead Sponsor: University of Washington

Target Recruit Count: 6

Registration Number: NCT01148966

Locations: 🇺🇸
Fred Hutchinson Cancer Research Center/University of Washington Cancer Consortium, Seattle, Washington, United States

A Study of the Specificity and Sensitivity of 5-ALA Fluorescence in Malignant Brain Tumors

Phase 1

Withdrawn

Conditions: Brain Neoplasms

Interventions: Drug: 5-aminolevulinic acid

First Posted Date: 2009-09-16

Last Posted Date: 2019-09-10

Lead Sponsor: NorthShore University HealthSystem

Registration Number: NCT00977795

Safety Study of Aminolevulinic Acid (ALA) to Improve Visibility of Brain Tumors During Surgery

Phase 2

Completed

Conditions: Glioblastoma

Interventions: Drug: Aminolevulinic Acid

First Posted Date: 2009-08-18

Last Posted Date: 2019-04-12

Lead Sponsor: Matthew R Quigley

Target Recruit Count: 72

Registration Number: NCT00961090

Locations: 🇺🇸
Allegheny General Hospital, Pittsburgh, Pennsylvania, United States

Fluorescence Guided Resection of Brain Tumors

Phase 1

Completed

Conditions: Brain Tumors

Interventions: Drug: 5-aminolevulinic acid

First Posted Date: 2009-03-27

Last Posted Date: 2019-06-14

Lead Sponsor: David W. Roberts

Target Recruit Count: 105

Registration Number: NCT00870779

Locations: 🇺🇸
Dartmouth-Hitchcock Medical Center, Lebanon, New Hampshire, United States

ALA-PDT Versus Vehicle PDT for Treatment of AK and Reduction of New NMSC in Solid Organ Transplant Recipients

Phase 2

Terminated

Conditions: Actinic Keratoses
Skin Neoplasms

Interventions: Drug: Aminolevulinic Acid
Other: Vehicle

First Posted Date: 2009-03-19

Last Posted Date: 2011-10-21

Lead Sponsor: DUSA Pharmaceuticals, Inc.

Target Recruit Count: 6

Registration Number: NCT00865878

Locations: 🇺🇸
The Mount Sinai Medical Center, New York, New York, United States
🇺🇸
University of California, Irvine, Irvine, California, United States
🇺🇸
Fox Chase Cancer Center, Philadelphia, Pennsylvania, United States

and more 4 locations

Imaging Procedure Using ALA in Finding Residual Tumor in Grade IV Malignant Astrocytoma

Phase 2

Completed

Conditions: Brain and Central Nervous System Tumors

Interventions: Drug: aminolevulinic acid
Procedure: Surgical Resection

First Posted Date: 2008-09-15

Last Posted Date: 2021-09-17

Lead Sponsor: Andrew Sloan, MD

Target Recruit Count: 73

Registration Number: NCT00752323

Locations: 🇺🇸
University Hospitals Cleveland Medical Center, Case Comprehensive Cancer Center, Cleveland, Ohio, United States

Study of Aminolevulinic Acid to Enhance Visualization and Resection of Malignant Glial Tumors of the Brain

Phase 1

Completed

Conditions: Brain Tumors

First Posted Date: 2008-05-05

Last Posted Date: 2011-01-14

Lead Sponsor: Advocate Hospital System

Target Recruit Count: 26

Registration Number: NCT00671710

Locations: 🇺🇸
Advocate Lutheran General Hospital, Park Ridge, Illinois, United States

Topical Aminolevulinic Acid in Patients With Nonmelanoma Skin Cancer

Early Phase 1

Terminated

Conditions: Non-melanomatous Skin Cancer

First Posted Date: 2008-04-22

Last Posted Date: 2017-01-02

Lead Sponsor: The Cleveland Clinic

Target Recruit Count: 18

Registration Number: NCT00663910

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