Overview
Beremagene geperpavec is a live, replication-defective herpes simplex virus type 1 (HSV-1)-based vector therapy. Developed by Krystal Biotech, it was first approved by the FDA on May 19, 2023, for the treatment of wounds associated with dystrophic epidermolysis bullosa (DEB). DEB is caused by mutations in the COL7A1 gene that encodes collagen VII (COL7), a major component of the anchoring fibrils for dermal–epidermal cohesion. Beremagene geperpavec is genetically modified to deliver COL7A1, thereby restoring the levels of the COL7 protein.
Indication
Beremagene geperpavec is indicated for the treatment of wounds in patients six months of age and older with dystrophic epidermolysis bullosa with mutation(s) in the collagen type VII alpha 1 chain (COL7A1) gene.
Associated Conditions
- Wound
Clinical Trials
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