Naldemedine (Symproic, Rizmoic)

概览

Naldemedine is an opioid antagonist used to to treat opioid-induced constipation.

作用机制

Naldemedine binds to and antagonizes mu-, delta-, and kappa-opioid receptors . The binding of opioid agonists to peripheral mu-opioid receptors slows the transit of feces through the intestine resulting in constipation. By antagonizing mu-opioid receptors, naldemedine inhibits this effect.

适应症

For the treatment of opioid-induced constipation .

• Opioid Induced Constipation (OIC)