Tadalafil
- Generic Name
- Tadalafil
- Brand Names
- Adcirca, Alyq, Cialis, Entadfi, Tadliq, Talmanco (previously Tadalafil Generics), Tadalafil Mylan, Tadalafil Lilly, Adcirca (previously Tadalafil Lilly)
- Drug Type
- Small Molecule
- Chemical Formula
- C22H19N3O4
- CAS Number
- 171596-29-5
- Unique Ingredient Identifier
- 742SXX0ICT
- Background
Tadalafil is a selective phosphodiesterase-5 inhibitor that is used in the treatment of erectile dysfunction (ED), pulmonary arterial hypertension (PAH), and benign prostatic hypertrophy. It was first approved in 2003 by the FDA for use in ED and later in 2009 for PAH. In contrast to other PDE5 inhibitors like sildenafil, tadalafil has greater selectivity fo...
- Indication
Tadalafil is indicated for the treatment of erectile dysfunction (ED) and either alone or in combination with finasteride for the treatment of benign prostatic hypertrophy (BPH). It is also indicated for the treatment of pulmonary arterial hypertension (PAH) both alone and in combination with macitentan or other endothelin-1 antagonists.
- Associated Conditions
- Benign Prostatic Hyperplasia (BPH), Erectile Dysfunction, Pulmonary Arterial Hypertension (PAH)
- Associated Therapies
- -
Administration of Tadalafil in Patients With Benign Prostatic Hyperplasia
- First Posted Date
- 2024-06-20
- Last Posted Date
- 2024-08-23
- Lead Sponsor
- Al-Azhar University
- Target Recruit Count
- 306
- Registration Number
- NCT06466369
- Locations
- 🇪🇬
outpatient clinic of the urology department at AlZahraa University Hospital, Al-Azhar University, Faculty of Medicine for Girls., Cairo, Egypt
Vasodilator and Exercise Study for DMD (VASO-REx)
- First Posted Date
- 2024-03-04
- Last Posted Date
- 2024-06-25
- Lead Sponsor
- University of Florida
- Target Recruit Count
- 50
- Registration Number
- NCT06290713
- Locations
- 🇺🇸
University of Florida Clinical and Translational Research Building, Gainesville, Florida, United States
The Effects of a Nitrate Supplementation on Erectile Function
- Conditions
- Interventions
- First Posted Date
- 2024-01-19
- Last Posted Date
- 2024-01-19
- Lead Sponsor
- RHA Investments Ltd
- Target Recruit Count
- 20
- Registration Number
- NCT06213077
- Locations
- 🇺🇸
OnSite Clinical Solutions, Charlotte, North Carolina, United States
Effect of Tadalafil, Sildenafil and Pentoxyfylline on Frozen Embryo Transfer Outcomes
- Conditions
- Interventions
- First Posted Date
- 2023-08-02
- Last Posted Date
- 2023-08-03
- Lead Sponsor
- Beni-Suef University
- Target Recruit Count
- 200
- Registration Number
- NCT05971667
- Locations
- 🇪🇬
Beni-suef university Hospital, Banī Suwayf, Beni Suef, Egypt
Breathe Easier With Tadalafil Therapy for Dyspnea in COPD-PH
- Conditions
- Interventions
- First Posted Date
- 2023-07-10
- Last Posted Date
- 2024-06-27
- Lead Sponsor
- VA Office of Research and Development
- Target Recruit Count
- 126
- Registration Number
- NCT05937854
- Locations
- 🇺🇸
Atlanta VA Medical and Rehab Center, Decatur, GA, Decatur, Georgia, United States
🇺🇸VA Boston Healthcare System Jamaica Plain Campus, Jamaica Plain, MA, Boston, Massachusetts, United States
🇺🇸Providence VA Medical Center, Providence, RI, Providence, Rhode Island, United States
Tadalafil for Severe Pulmonary Hypertension Due to Chronic Obstructive Pulmonary Disease
- Conditions
- Interventions
- First Posted Date
- 2023-05-06
- Last Posted Date
- 2024-06-21
- Lead Sponsor
- Assistance Publique - Hôpitaux de Paris
- Target Recruit Count
- 200
- Registration Number
- NCT05844462
- Locations
- 🇫🇷
Kremlin Bicêtre, Kremlin Bicêtre, France
Comparison Between Tamsulosin and Tadalafil in Management of Benign Prostatic Hyperplasia Long Term Study
- First Posted Date
- 2023-04-19
- Last Posted Date
- 2023-04-19
- Lead Sponsor
- Mansoura University
- Target Recruit Count
- 160
- Registration Number
- NCT05818670
- Locations
- 🇪🇬
Ahmed Atta Elqaffas, Mansoura, Dakahlia, Egypt
🇪🇬Urology and Nephrology Center at Mansoura University, Mansoura, Dakahlia, Egypt
Silodosin, Tadalafil Alone vs. Silodosin Plus Tadalafil as MET for Lower Ureteric Stones
- Conditions
- Interventions
- First Posted Date
- 2023-03-29
- Last Posted Date
- 2023-03-31
- Lead Sponsor
- Benha University
- Target Recruit Count
- 168
- Registration Number
- NCT05789732
- Locations
- 🇪🇬
Benha University Hospitals, Benha, Egypt
Study of Tadalafil Vs. Placebo for Improving Hemodynamics and End-Organ Dysfunction in Fontan Physiology
- First Posted Date
- 2022-01-25
- Last Posted Date
- 2024-11-11
- Lead Sponsor
- Mayo Clinic
- Target Recruit Count
- 80
- Registration Number
- NCT05206955
- Locations
- 🇺🇸
Mayo Clinic, Rochester, Minnesota, United States
Tadalafil as Adjuvant Therapy for DMD
- First Posted Date
- 2022-01-19
- Last Posted Date
- 2024-11-06
- Lead Sponsor
- University of Florida
- Target Recruit Count
- 25
- Registration Number
- NCT05195775
- Locations
- 🇺🇸
University of Florida, Gainesville, Florida, United States
Drug Development Updates
Stay informed with timely notifications on clinical trials, regulatory changes, and research advancements related to this medication.