Dexamethasone, or MK-125, is a corticosteroid fluorinated at position 9 used to treat endocrine, rheumatic, collagen, dermatologic, allergic, ophthalmic, gastrointestinal, respiratory, hematologic, neoplastic, edematous, and other conditions. Developed in 1957, it is structurally similar to other corticosteroids like hydrocortisone and prednisolone.
Dexamethasone was granted FDA approval on 30 October 1958. In a press release for the Randomized Evaluation of COVID-19 Therapy (RECOVERY) trial on 16 June 2020, dexamethasone was recommended for use in COVID-19 patients with severe respiratory symptoms. Dexamethasone reduced deaths by approximately one third in patients requiring ventilation and by one fifth in those requiring oxygen.
Dexamethasone and ciprofloxacin otic suspension is indicated for bacterial infections with inflammation in acute otitis media and acute otitis externa. Intramuscular and intravenous injections are indicated for a number of endocrine, rheumatic, collagen, dermatologic, allergic, ophthalmic, gastrointestinal, respiratory, hematologic, neoplastic, edematous, and other conditions. Oral tablets are indicated for the treatment of multiple myeloma. An intravitreal implant is indicated for some forms of macular edema and non-infectious posterior uveitis affecting the posterior of the eye. Various ophthalmic formulations are indicated for inflammatory conditions of the eye.
Oregon Health & Science University Cancer Institute, Portland, Oregon, United States
Children's Hospital of Columbus, Columbus, Ohio, United States
Ireland Cancer Center, Cleveland, Ohio, United States
Children's National Medical Center, Washington, District of Columbia, United States
Fred Hutchinson Cancer Research Center/University of Washington Cancer Consortium, Seattle, Washington, United States
USC/Norris Comprehensive Cancer Center and Hospital, Los Angeles, California, United States
Cancer Center and Beckman Research Institute, City of Hope, Duarte, California, United States
Ingalls Memorial Hospital, Harvey, Illinois, United States
USC/Norris Comprehensive Cancer Center and Hospital, Los Angeles, California, United States
Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, Maryland, United States
New England Medical Center Hospital, Boston, Massachusetts, United States
Beth Israel Deaconess Medical Center, Boston, Massachusetts, United States
Credit Valley Hospital, Mississauga, Ontario, Canada
Cancer Care Ontario-Hamilton Regional Cancer Centre, Hamilton, Ontario, Canada
Princess Margaret Hospital, Toronto, Ontario, Canada
Warren Grant Magnuson Clinical Center - NCI Clinical Studies Support, Bethesda, Maryland, United States
Mount Sinai Medical Center, NY, New York, New York, United States
National Heart, Lung, and Blood Institute, Bethesda, Maryland, United States
CCOP - Christiana Care Health Services, Wilmington, Delaware, United States
CancerCare Manitoba, Winnipeg, Manitoba, Canada
Cancer Care Ontario-London Regional Cancer Centre, London, Ontario, Canada
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