Dexamethasone

Generic Name: Dexamethasone

Brand Names: Baycadron, Ciprodex, Decadron, Dexamethasone Intensol, Dextenza, Dioptrol, Hexadrol, Hidex 6-day Taper, Maxidex, Maxitrol, Neofordex, Ozurdex, Taperdex 12 Day Taper, Taperdex 6 Day Taper, Taperdex 7-day Taper, Tobradex, Zcort 7 Day Taper

Drug Type: Small Molecule

Chemical Formula: C_₂₂H_₂₉FO_₅

CAS Number: 50-02-2

Unique Ingredient Identifier: 7S5I7G3JQL

Background: Dexamethasone, or MK-125, is a corticosteroid fluorinated at position 9 used to treat endocrine, rheumatic, collagen, dermatologic, allergic, ophthalmic, gastrointestinal, respiratory, hematologic, neoplastic, edematous, and other conditions. Developed in 1957, it is structurally similar to other corticosteroids like hydrocortisone and prednisolone.

Dexamethasone was granted FDA approval on 30 October 1958. In a press release for the Randomized Evaluation of COVID-19 Therapy (RECOVERY) trial on 16 June 2020, dexamethasone was recommended for use in COVID-19 patients with severe respiratory symptoms. Dexamethasone reduced deaths by approximately one third in patients requiring ventilation and by one fifth in those requiring oxygen.

Indication: Dexamethasone and ciprofloxacin otic suspension is indicated for bacterial infections with inflammation in acute otitis media and acute otitis externa. Intramuscular and intravenous injections are indicated for a number of endocrine, rheumatic, collagen, dermatologic, allergic, ophthalmic, gastrointestinal, respiratory, hematologic, neoplastic, edematous, and other conditions. Oral tablets are indicated for the treatment of multiple myeloma. An intravitreal implant is indicated for some forms of macular edema and non-infectious posterior uveitis affecting the posterior of the eye. Various ophthalmic formulations are indicated for inflammatory conditions of the eye.

Associated Conditions: Acute Gouty Arthritis, Acute Leukemia, Acute Otitis Externa, Acute Otitis Media (AOM), Adrenocortical Hyperfunction, Adrenocortical Insufficiency, Allergic Conjunctivitis (AC), Alopecia Areata (AA), Ankylosing Spondylitis (AS), Aspiration Pneumonitis, Asthma, Atopic Dermatitis, Berylliosis, Bullous dermatitis herpetiformis, Bursitis, Chorioretinitis, Choroiditis, Congenital Adrenal Hyperplasia (CAH), Congenital Hypoplastic Anemia, Conjunctivitis, Contact Dermatitis, Cushing's Syndrome, Dermatitis, Diabetic Macular Edema (DME), Discoid Lupus Erythematosus (DLE), Drug hypersensitivity reaction, Edema of the cerebrum, Epicondylitis, Episcleritis, Erythroblastopenia, Eye Infections, Eye allergy, Glaucoma, Hypercalcemia, Immune Thrombocytopenia (ITP), Infection, Inflammation, Inflammation of the External Auditory Canal, Intraocular Inflammation, Iridocyclitis, Iritis, Keloids Scars, Keratitis, Lichen Planus (LP), Lichen simplex chronicus, Loeffler's syndrome, Lymphoma, Macular Edema, Meningitis caused by Mycobacterium Tuberculosis, Middle ear inflammation, Mucosal Inflammation of the eye, Multiple Myeloma (MM), Muscle Inflammation caused by Cataract Surgery of the eye, Mycosis Fungoides (MF), Necrobiosis lipoidica diabeticorum, Non-infectious Posterior Uveitis, Ocular Infections, Irritations and Inflammations, Ocular Inflammation, Ocular Inflammation and Pain, Ocular Irritation, Ocular Itching, Ophthalmia, Sympathetic, Optic Neuritis, Otitis Externa, Pemphigus, Perennial Allergic Rhinitis (PAR), Phlyctenular keratoconjunctivitis, Postoperative Infections of the eyes caused by susceptible bacteria, Posttraumatic Osteoarthritis, Regional Enteritis, Rheumatoid Arthritis, Rheumatoid Arthritis, Juvenile, Rosacea, Sarcoidosis, Scleritis, Seasonal Allergic Rhinitis, Secondary thrombocytopenia, Serum Sickness, Severe Seborrheic Dermatitis, Stevens-Johnson Syndrome, Synovitis, Systemic Lupus Erythematosus, Tenosynovitis, Trichinosis, Tuberculosis (TB), Ulcerative Colitis, Uveitis, Vernal Keratoconjunctivitis, Acquired immune hemolytic anemia, Acute rheumatic carditis, Anterior eye segment inflammation, Corticosteroid-responsive dermatoses, Ear infection-not otherwise specified caused by susceptible bacteria, Exfoliative erythroderma, Granuloma annulare lesions, Non-suppurative Thyroiditis, Ocular bacterial infections, Severe Psoriasis, Steroid-responsive inflammation of the eye, Swelling of the eyes, Varicella-zoster virus acute retinal necrosis, Watery itchy eyes

Associated Therapies: -

Clinical Trials

Effect of Dexamethasone as Analgesic Treatment After Total Knee Arthroplasty

Phase 4

Completed

Conditions: Postoperative Pain

Interventions: Drug: Dexamethasone
Drug: Isotonic saline

First Posted Date: 2021-08-17

Last Posted Date: 2021-09-13

Lead Sponsor: Naestved Hospital

Target Recruit Count: 485

Registration Number: NCT05008367

Locations: 🇩🇰
Næstsved Sygehus, Næstved, Denmark
🇩🇰
Gildhøj Privathospital, Brøndbyvester, Denmark
🇩🇰
Sjællands Universitetshospital, Køge, Køge, Denmark

and more 2 locations

A Study to Evaluate the Safety and Efficacy of Artemisinin- a Herbal Supplement on COVID-19 Subjects

Phase 4

Completed

Conditions: Covid19

Interventions: Dietary Supplement: Artemisinin
Drug: Dexamethasone

First Posted Date: 2021-08-13

Last Posted Date: 2021-09-09

Lead Sponsor: Mateon Therapeutics

Target Recruit Count: 120

Registration Number: NCT05004753

Locations: 🇮🇳
Seven Star Hospital, Nagpur, Maharashtra, India
🇮🇳
Government Medical College & Government General Hospital, Srikakulam, Srikakulam, Andhra Pradesh, India
🇮🇳
Rajarshi Chhatrapati Shahu Maharaj Government Medical college and Chhatrapati Pramila Raje Hospital, Kolhapur, Maharashtra, India

Effect of Dexamethasone Shortly Before Surgery on the Intraoperative Dose of Remifentanil

Phase 4

Completed

Conditions: Perioperative Pain

Interventions: Drug: Dexamethasone
Drug: Isotonic saline

First Posted Date: 2021-08-12

Last Posted Date: 2021-08-12

Lead Sponsor: Naestved Hospital

Target Recruit Count: 94

Registration Number: NCT05002361

Locations: 🇩🇰
Næstsved Sygehus, Næstved, Denmark
🇩🇰
Sjællands Universitetshospital, Køge, Køge, Denmark
🇩🇰
Odense Universitetshospital, Odense, Denmark

and more 2 locations

Efficacy of Soluble Dexamethasone in Refractory Sciatica

Phase 3

Completed

Conditions: Sciatica

Interventions: Drug: Dexamethasone phosphate

First Posted Date: 2021-08-11

Last Posted Date: 2024-02-01

Lead Sponsor: Nantes University Hospital

Target Recruit Count: 109

Registration Number: NCT05000658

Locations: 🇫🇷
Nantes University Hospital, Nantes, France

Palbociclib in Combination With Chemotherapy in Pediatric Patients With Relapsed or Refractory Acute Lymphoblastic Leukemia (RELPALL2)

Phase 1

Recruiting

Conditions: Relapsed Acute Lymphoblastic Leukemia
Refractory Acute Lymphoblastic Leukemia
Acute Lymphoblastic Leukemia, Pediatric

Interventions: Drug: Palbociclib
Drug: Dexamethasone
Drug: Bortezomib
Drug: Doxorubicin

First Posted Date: 2021-08-09

Last Posted Date: 2024-04-16

Lead Sponsor: Tanja Andrea Gruber

Target Recruit Count: 22

Registration Number: NCT04996160

Locations: 🇺🇸
Lucile Packard Children's Hospital Stanford, Stanford, California, United States

Selinexor for Treatment of Light Chain Amyloidosis With Relapsed/Refractory Disease

Early Phase 1

Withdrawn

Conditions: Amyloid
Amyloidosis
AL Amyloidosis

Interventions: Drug: Selinexor
Drug: Dexamethasone

First Posted Date: 2021-07-30

Last Posted Date: 2022-11-17

Lead Sponsor: Weill Medical College of Cornell University

Registration Number: NCT04984330

Locations: 🇺🇸
Weill Cornell Medicine - Multiple Myeloma Center, New York, New York, United States

Open-label Study Comparing Iberdomide, Daratumumab and Dexamethasone (IberDd) Versus Daratumumab, Bortezomib, and Dexamethasone (DVd) in Participants With Relapsed or Refractory Multiple Myeloma (RRMM)

Phase 3

Recruiting

Conditions: Multiple Myeloma

Interventions: Drug: Dexamethasone
Drug: Daratumumab
Drug: Bortezomib
Drug: Iberdomide

First Posted Date: 2021-07-26

Last Posted Date: 2024-12-04

Lead Sponsor: Celgene

Target Recruit Count: 864

Registration Number: NCT04975997

Locations: 🇺🇸
Ohio Health Corporation, Columbus, Ohio, United States
🇺🇸
MetroHealth Medical Center - Main Campus, Cleveland, Ohio, United States
🇺🇸
Cleveland Clinic - Taussig Cancer Institute, Cleveland, Ohio, United States

and more 279 locations

A Study to Evaluate an Updated Dexamethasone Intravitreal (Into the Eye) Applicator in Adult Participants With Macular Edema Due to Diseases of the Retina

Phase 3

Completed

Conditions: Macular Edema

Interventions: Device: Updated DEX PS DDS Applicator
Device: Approved DEX PS DDS Applicator
Drug: Dexamethasone

First Posted Date: 2021-07-26

Last Posted Date: 2023-02-28

Lead Sponsor: AbbVie

Target Recruit Count: 54

Registration Number: NCT04976777

Locations: 🇺🇸
North Texas Retina Consultants /ID# 241013, Willow Park, Texas, United States
🇺🇸
Global Research Management /ID# 238944, Glendale, California, United States
🇺🇸
Retina Research Institute of Texas /ID# 231420, Abilene, Texas, United States

and more 4 locations

A Phase 1b/2 Study of BGB-11417in Monotherapy and in Various Combinations With Dexamethasone and Carfilzomib in Multiple Myeloma

Phase 1

Recruiting

Conditions: Relapsed/Refractory Multiple Myeloma

Interventions: Drug: BGB-11417
Drug: Dexamethasone
Drug: Carfilzomib

First Posted Date: 2021-07-22

Last Posted Date: 2024-12-13

Lead Sponsor: BeiGene

Target Recruit Count: 167

Registration Number: NCT04973605

Locations: 🇺🇸
City of Hope At Irvine Lennar, Irvine, California, United States
🇺🇸
Southern Illinois University School of Medicine, Springfield, Illinois, United States
🇺🇸
University of California At San Francisco, San Francisco, California, United States

and more 85 locations

Baricitinib in Hospitalized Covid-19 Patients With Diabetes Mellitus

Phase 3

Withdrawn

Conditions: COVID-19 Pneumonia

Interventions: Drug: Baricitinib
Drug: Dexamethasone
Drug: Remdesivir

First Posted Date: 2021-07-21

Last Posted Date: 2024-04-09

Lead Sponsor: Bangladesh Institute of Research and Rehabilitation in Diabetes, Endocrine and Metabolic Disorders

Registration Number: NCT04970719

Locations: 🇧🇩
Kurigram Adhunik Sadar Hospital, Kurigram, Bangladesh
🇧🇩
Rajshahi Medical College & Hospital, Rajshahi, Bangladesh
🇧🇩
Debidwar Upazila Health Complex, Comilla, Bangladesh

and more 4 locations

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