甲氯芬那酸

概览

Meclofenamic acid is an NSAID used to treat mild to moderate pain, primary dysmenorrhea, heavy menstrual blood loss, rheumatoid arthritis, and osteoarthritis.

作用机制

The mode of action, like that of other nonsteroidal anti-inflammatory agents, is not known. Therapeutic action does not result from pituitary-adrenal stimulation. In animal studies, meclofenamic acid was found to inhibit prostaglandin synthesis and to compete for binding at the prostaglandin receptor site. In vitro meclofenamic acid was found to be an inhibitor of human leukocyte 5-lipoxygenase activity. These properties may be responsible for the anti-inflammatory action of meclofenamic acid. There is no evidence that meclofenamic acid alters the course of the underlying disease.

适应症

For the relief of mild to moderate pain, for the treatment of primary dysmenorrhea and for the treatment of idiopathic heavy menstrual blood loss. Also for relief of the signs and symptoms of acute and chronic rheumatoid arthritis and osteoarthritis.

• Acute Gouty Arthritis
• Ankylosing Spondylitis (AS)
• Fever
• Hypermenorrhea
• Juvenile Idiopathic Arthritis (JIA)
• Mild pain
• Osteoarthritis (OA)
• Primary Dysmenorrhoea
• Rheumatoid Arthritis
• Acute Subacromial bursitis
• Moderate Pain
• Supraspinatus tendinitis