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Cetylpyridinium chloride

Generic Name
Cetylpyridinium chloride
Brand Names
Cepacol Antibacterial Mouthwash, Crest Mouthwash, Orajel Bleeding Gum Rinse, Orasep Reformulated Dec 2013
Drug Type
Small Molecule
Chemical Formula
C21H38N
CAS Number
7773-52-6
Unique Ingredient Identifier
CUB7JI0JV3

Overview

Cetylpyridinium is a quaternary ammonium with broad-spectrum antiseptic properties. Its salt form, cetylpyridinium chloride, is typically found as an active ingredient in mouthwashes, toothpastes, lozenges, throat sprays, breath sprays, and nasal sprays. In these products, it generally mediates an antiseptic activity and protective action against dental plaque and reducing gingivitis.

Background

Cetylpyridinium is a quaternary ammonium with broad-spectrum antiseptic properties. Its salt form, cetylpyridinium chloride, is typically found as an active ingredient in mouthwashes, toothpastes, lozenges, throat sprays, breath sprays, and nasal sprays. In these products, it generally mediates an antiseptic activity and protective action against dental plaque and reducing gingivitis.

Indication

Typically employed as the cetylpyridinium chloride salt, this compound is commonly used as an active ingredient in various over-the-counter mouthwashes, toothpastes, lozenges, and mouth sprays where it is generally indicated for antiseptic actions, gingivitis and plaque prevention, as well as action or prevention against some other oropharyngeal bacterial infections .

Associated Conditions

  • Gingivitis
  • Oral Pain
  • Pain, Orofacial
  • Sore Throat
  • Stomatitis
  • Teething pain
  • Throat irritation
  • Dry cough
  • Gum pain
  • Oral discomfort and pain
  • Oral infections
  • Pain in throat
  • Throat infections
  • Throat inflammation

FDA Approved Products

CPH Anti-bacterial Breath Mist
Manufacturer:OraLabs
Route:TOPICAL
Strength:1.11 g in 13 mL
Approved: 2025/04/22
NDC:63645-179
Antigingivitis/Antiplaque
Manufacturer:Consumer Product Partners, LLC
Route:ORAL
Strength:0.7 mg in 1 mL
Approved: 2025/05/07
NDC:11344-900
Parodontax Active Gum Health Daily Mouthwash Breath Freshener
Manufacturer:Haleon US Holdings LLC
Route:ORAL
Strength:70 mg in 1 mL
Approved: 2025/05/08
NDC:0135-0652
ANTISEPTIC
Manufacturer:Valu Merchandisers.Co
Route:ORAL
Strength:0.7 mg in 1 mL
Approved: 2025/05/20
NDC:63941-299
CloSYS Silver Healthy Gums
Manufacturer:Rowpar Pharmaceuticals, Inc.
Route:ORAL
Strength:0.75 g in 1 mL
Approved: 2025/05/16
NDC:58578-0407

Singapore Approved Products

SORAGEL ANTISEPTIC PAIN RELIEVING ORAL GEL
Manufacturer:ICM PHARMA PTE. LTD.
Form:GEL
Strength:0.01% w/w
Online:Yes
Approved: 1998/11/16
Approval:SIN10428P
DENTINOX TEETHING GEL
Manufacturer:Dendron Brands Ltd
Form:GEL
Strength:0.1% w/w
Online:Yes
Approved: 1990/03/28
Approval:SIN04042P
DIFFLAM ANTI-INFLAMMATORY LOZENGE (WITH ANTIBACTERIAL) (HONEY LEMON)
Manufacturer:Unique Pharmaceuticals Laboratories
Form:LOZENGE
Strength:1.33 mg
Online:Yes
Approved: 2003/06/13
Approval:SIN12320P
DIFFLAM ANTI-INFLAMMATORY LOZENGE (WITH ANTIBACTERIAL) (RASPBERRY RELIEF)
Manufacturer:Unique Pharmaceuticals Laboratories
Form:LOZENGE
Strength:1.33 mg
Online:Yes
Approved: 2003/06/13
Approval:SIN12321P
DIFFLAM MOUTH GEL
Manufacturer:Ensign Laboratories Pty Ltd
Form:GEL
Strength:1 mg/g
Online:Yes
Approved: 1998/08/28
Approval:SIN09963P

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