Sirolimus
- Generic Name
- Sirolimus
- Brand Names
- Fyarro, Hyftor, Rapamune
- Drug Type
- Small Molecule
- Chemical Formula
- C51H79NO13
- CAS Number
- 53123-88-9
- Unique Ingredient Identifier
- W36ZG6FT64
- Background
Sirolimus, also known as rapamycin, is a macrocyclic lactone antibiotic produced by bacteria Streptomyces hygroscopicus, which was isolated from the soil of the Vai Atari region of Rapa Nui (Easter Island). It was first isolated and identified as an antifungal agent with potent anticandida activity; however, after its potent antitumor and immunosuppressive a...
- Indication
Sirolimus is indicated for the prophylaxis of organ rejection in patients aged 13 years or older receiving renal transplants. In patients at low-to moderate-immunologic risk, it is recommended that sirolimus be used initially in a regimen with cyclosporine and corticosteroids; cyclosporine should be withdrawn two to four months after transplantation. In pati...
- Associated Conditions
- Chordomas, Facial Angiofibroma, Graft-versus-host Disease (GVHD), Heart Transplant Rejection, Liver Transplant Rejection, Lung Transplant Rejection, Lymphangioleiomyomatosis (LAM), Renal Angiomyolipomas, Transplanted Organ Rejection, Metastatic malignant Perivascular Epithelioid Cell Neoplasms, Unresectable, locally advanced malignant Perivascular Epithelioid Cell Neoplasms
- Associated Therapies
- -
Study Evaluating Rapamune in Patients After Kidney Transplantation
- First Posted Date
- 2005-10-17
- Last Posted Date
- 2008-03-14
- Lead Sponsor
- Wyeth is now a wholly owned subsidiary of Pfizer
- Target Recruit Count
- 500
- Registration Number
- NCT00240214
Rapamycin in Combination With Low-dose Aracytin in Elderly Acute Myeloid Leukemia Patients
- First Posted Date
- 2005-10-10
- Last Posted Date
- 2024-02-29
- Lead Sponsor
- University Hospital, Toulouse
- Target Recruit Count
- 50
- Registration Number
- NCT00235560
- Locations
- 🇫🇷
Service d'Hématologie, Hôpital Jean Minjoz, BESANçON, France
🇫🇷Service d'Hématologie, CHU, Angers, France
🇫🇷Service d'Hématologie CHU Purpan, Toulouse, France
Polymorphism of the Cytochrome P450-system in Renal Transplants
- Conditions
- First Posted Date
- 2005-09-22
- Last Posted Date
- 2011-08-04
- Lead Sponsor
- University Hospital Schleswig-Holstein
- Target Recruit Count
- 200
- Registration Number
- NCT00223054
- Locations
- 🇩🇪
University of Schleswig-Holstein, Campus Kiel, Department of Nephrology, Kiel, Germany
Mycophenolate Mofetil and Rapamycin as Secondary Intervention vs. Continuation of Calcineurin Inhibitors in Patients at Risk for Chronic Renal Allograft Failure
- First Posted Date
- 2005-09-22
- Last Posted Date
- 2017-06-21
- Lead Sponsor
- Vanderbilt University Medical Center
- Target Recruit Count
- 20
- Registration Number
- NCT00223678
- Locations
- 🇺🇸
Vanderbilt University, Nashville, Tennessee, United States
Study Evaluating Rapamune in Transplant Recipients in the Nordic Countries
- First Posted Date
- 2005-09-19
- Last Posted Date
- 2012-01-31
- Lead Sponsor
- Wyeth is now a wholly owned subsidiary of Pfizer
- Target Recruit Count
- 66
- Registration Number
- NCT00195195
A Study Comparing the Withdrawal of Steroids or Tacrolimus in Kidney Transplant Recipients
- Conditions
- Interventions
- First Posted Date
- 2005-09-19
- Last Posted Date
- 2023-12-11
- Lead Sponsor
- Wyeth is now a wholly owned subsidiary of Pfizer
- Target Recruit Count
- 47
- Registration Number
- NCT00195429
Study Evaluating Sirolimus in Kidney Transplant Recipients
- Conditions
- Interventions
- First Posted Date
- 2005-09-19
- Last Posted Date
- 2010-04-28
- Lead Sponsor
- Wyeth is now a wholly owned subsidiary of Pfizer
- Target Recruit Count
- 61
- Registration Number
- NCT00195273
Using Donor Stem Cells and Alemtuzumab to Prevent Organ Rejection in Kidney Transplant Patients
- First Posted Date
- 2005-09-16
- Last Posted Date
- 2012-10-02
- Lead Sponsor
- University of Miami
- Target Recruit Count
- 9
- Registration Number
- NCT00183248
- Locations
- 🇺🇸
University of Miami, Miami, Florida, United States
Pilot Study on the Use of Sirolimus to Treat Chronic Allograft Nephropathy in Children After Kidney Transplant
- Conditions
- First Posted Date
- 2005-09-16
- Last Posted Date
- 2010-02-22
- Lead Sponsor
- University of Manitoba
- Target Recruit Count
- 40
- Registration Number
- NCT00188955
- Locations
- 🇨🇦
Children's Hospital, Winnipeg, Manitoba, Canada
Efficacy of Sirolimus-Based, Steroid Avoidance Immunosuppression African Americans
- First Posted Date
- 2005-09-16
- Last Posted Date
- 2018-03-27
- Lead Sponsor
- University of Michigan
- Target Recruit Count
- 49
- Registration Number
- NCT00189202
- Locations
- 🇺🇸
University of Michigan Health Center, Ann Arbor, Michigan, United States
Drug Development Updates
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