Shionogi & Co., Ltd. has been awarded a $375 million project agreement by BARDA to develop S-892216, a long-acting injectable antiviral for COVID-19 pre-exposure prophylaxis. This initiative aims to address the unmet need for effective pre-exposure prophylaxis therapeutics, with phase 1 studies expected to begin in 2025. S-892216, a second-generation 3CL protease inhibitor, has shown strong antiviral effects in pre-clinical trials and is being developed in both injectable and oral forms.