Acetyl sulfisoxazole

Sulfisoxazole acetyl is an ester of sulfisoxazole, a broad-spectrum sulfanilamide and a synthetic analog of para-aminobenzoic acid (PABA) with antibacterial activity. Sulfisoxazole acetyl competes with PABA for the bacterial enzyme, dihydropteroate synthase, preventing the incorporation of PABA into dihydrofolic acid, which is the precursor of folic acid. This process causes an inhibition of bacterial folic acid synthesis and de novo synthesis of purines and pyrimidines, resulting in cell growth arrest and cell death . It is often combined with erythromycin to treat acute otitis media caused by the bacteria, haemophilus influenzae .

Acute, recurrent or chronic urinary tract infections (primarily pyelonephritis, pyelitis and cystitis) due to susceptible organisms (usually Escherichia coli, Klebsiella-Enterobacter, staphylococcus, Proteus mirabilis and, less frequently, Proteus vulgaris) in the absence of obstructive uropathy or foreign bodies Meningococcal meningitis where the organism has been demonstrated to be susceptible. Haemophilus influenzae meningitis as adjunctive therapy with parenteral streptomycin Meningococcal meningitis prophylaxis . Acute otitis media due to Haemophilus influenzae when used concomitantly with adequate doses of penicillin or erythromycin (see appropriate labeling for prescribing information) . Trachoma, inclusion conjunctivitis, nocardiosis, chancroid, toxoplasmosis as adjunctive therapy with pyrimethamine. Malaria due to chloroquine-resistant strains of Plasmodium falciparum, when used as adjunctive therapy . Currently, the increasing frequency of resistant organisms is a limitation of the usefulness of antibacterial agents including the sulfonamides, especially in the treatment of chronic and recurrent urinary tract infections .

• Acute Otitis Media caused by Haemophilus Influenzae
• Chancroid
• Conjunctivitis, Inclusion
• Malaria
• Meningitis caused by Haemophilus influenzae
• Meningococcal Meningitis
• Nocardiosis
• Toxoplasmosis
• Trachoma
• Acute, recurrent Urinary Tract Infection caused by Klebsiella Enterobacter, Staphylococcus, Proteus mirabilis, Proteus vulgaris, Escherichia Coli
• Chronic, recurrent Urinary Tract Infection caused by Klebsiella Enterobacter, Staphylococcus, Proteus mirabilis, Proteus vulgaris, Escherichia Coli