Overview
Metamizole (dipyrone) is a pyrazolone derivative that belongs to the group of nonacid nonopioids. It is considered a potent analgesic and antipyretic with favourable gastrointestinal tolerability. Metamizole was formerly marketed in the US as Dimethone tablets and injection, Protemp oral liquid, and other drug products, and was withdrawn due to its association with potentially fatal agranulocytosis. Approvals of the NDA's for metamizole drug products were withdrawn on June 27, 1977 (see the Federal Register of June 17, 1977, 42 FR 30893). In 1963, metamizole was withdrawn from the Canadian market and banned in the UK, France, Sweden, Norway and Australia. Metamizole is still used in certain countries in Europe, Asia and South America.
Indication
Metamizole is banned in several countries, where it was previously used as a powerful analgesic and fever reducer. In countries where it is still available, metamizole is indicated for acute severe pain after injuries or surgeries, colic, tumor pain, and acute or severe pain symptoms, as well as high fever if other treatments are unsuccessful.
Associated Conditions
- Severe Pain
- Severe Fever
Clinical Trials
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Title | Posted | Study ID | Phase | Status | Sponsor |
|---|---|---|---|---|---|
2017/08/09 | Phase 4 | Completed | |||
2017/06/29 | Phase 3 | UNKNOWN | Hospital General Universitario Elche | ||
2016/11/25 | Not Applicable | Completed | |||
2016/11/23 | Not Applicable | Completed | |||
2016/06/29 | Not Applicable | Completed | Universidade Estadual Paulista Júlio de Mesquita Filho | ||
2016/06/27 | Not Applicable | Completed | Universidade Estadual Paulista Júlio de Mesquita Filho | ||
2016/06/17 | Phase 4 | Completed | Michał Borys | ||
2016/03/17 | Phase 3 | Terminated | |||
2016/02/23 | Phase 4 | Terminated | |||
2016/02/19 | Phase 4 | Completed | University Hospital, Basel, Switzerland |
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