Overview
A fungistatic compound that is widely used as a food preservative. It is conjugated to GLYCINE in the liver and excreted as hippuric acid. As the sodium salt form, sodium benzoate is used as a treatment for urea cycle disorders due to its ability to bind amino acids. This leads to excretion of these amino acids and a decrease in ammonia levels. Recent research shows that sodium benzoate may be beneficial as an add-on therapy (1 gram/day) in schizophrenia. Total Positive and Negative Syndrome Scale scores dropped by 21% compared to placebo.
Background
A fungistatic compound that is widely used as a food preservative. It is conjugated to GLYCINE in the liver and excreted as hippuric acid. As the sodium salt form, sodium benzoate is used as a treatment for urea cycle disorders due to its ability to bind amino acids. This leads to excretion of these amino acids and a decrease in ammonia levels. Recent research shows that sodium benzoate may be beneficial as an add-on therapy (1 gram/day) in schizophrenia. Total Positive and Negative Syndrome Scale scores dropped by 21% compared to placebo.
Indication
⑴与水杨酸合用于成龙皮肤真菌病、浅部真菌感染的体癣、手癣及足癣等，但目前有更多的高效抗真菌药，本制剂可作为二线治疗药。也用于食品和药物制剂的防腐剂，一般浓度为0.2％，或用0.5％的苯甲酸钠，溶解度更好。 ⑵用于罕见病精氨酸酶缺乏症的治疗。
Associated Conditions
- Fungal Infections
- Oropharyngeal pain
- Pain
- Ringworm
- Sore Throat
- Tinea Pedis
- Burning sensation in the mouth
- Dry cough
- Oral infections
- Throat infections
Clinical Trials
Title | Posted | Study ID | Phase | Status | Sponsor |
|---|
No clinical trials found
No clinical trials found for this drug
FDA Drug Approvals
Approved Product | Manufacturer | NDC Code | Route | Strength | Effective Date |
|---|---|---|---|---|---|
| Mission Pharmacal Company | 0178-0745 | ORAL | 9 mg in 1 1 | 1/22/2024 | |
| Star Pharmaceuticals, LLC | 0076-0901 | ORAL | 9 mg in 1 1 | 1/5/2017 |
EMA Drug Approvals
Approved Product | Authorization Holder | Status | Issued Date |
|---|---|---|---|
| No EMA approvals found for this drug. | |||
HSA Drug Approvals
Approved Product | Manufacturer | Approval Number | Dosage Form | Strength | Approval Date |
|---|---|---|---|---|---|
| TINEA SKIN SOLUTION (THREE LEG BRAND) | SIN08773P | SOLUTION | 2% w/v | 7/3/1996 | |
| VEELANZ'S OINTMENT | SIN16547P | OINTMENT | 6.01% w/w | 7/7/2022 | |
| ROBINSON RINGWORM & WHITESPOT OINTMENT | SIN09544P | OINTMENT | 6% w/w | 11/21/1997 | |
| SAW HONG CHOON SKIN OINTMENT | SIN09830P | OINTMENT | 6% w/w | 6/18/1998 | |
| NIXODERM OINTMENT | SIN04418P | OINTMENT | 6.00% w/w | 5/3/1990 |
NMPA Drug Approvals
Approved Product | Company | Approval Number | Drug Type | Dosage Form | Approval Date |
|---|---|---|---|---|---|
| No NMPA approvals found for this drug. | |||||
PPB Drug Approvals
Approved Product | Registration No. | Company | Licence No. | Strength | Registration Date |
|---|---|---|---|---|---|
| NIZO SPRAY | N/A | N/A | N/A | 1/29/2001 | |
| SUSIK POWDER | N/A | unicorn laboratories o/b american unicorn laboratories limited | N/A | N/A | 7/3/1998 |
| DERMACORN FOOT SOAKING POWDER | N/A | unicorn laboratories o/b american unicorn laboratories limited | N/A | N/A | 7/14/2011 |
| RADISOL ACID SALICYLIC APPLICATION | N/A | N/A | N/A | 1/24/1979 | |
| CURCYTOL SKIN LOTION (SPRAY) | N/A | N/A | N/A | 2/11/1998 | |
| ZEMASALIC OINTMENT | N/A | meyer pharmaceuticals ltd | N/A | N/A | 2/16/1994 |
| WHITASALIC OINTMENT | N/A | meyer pharmaceuticals ltd | N/A | N/A | 2/16/1994 |
| MAGIC POWDER | N/A | unicorn laboratories o/b american unicorn laboratories limited | N/A | N/A | 10/14/2007 |
| ANTIVE SKIN LOTION | N/A | N/A | N/A | 9/19/1981 | |
| RICH POWDER | N/A | unicorn laboratories o/b american unicorn laboratories limited | N/A | N/A | 9/29/1999 |
TGA Drug Approvals
Approved Product | ARTG ID | Sponsor | Registration Type | Status | Registration Date |
|---|---|---|---|---|---|
| LISTERINE TEETH DEFENCE ANTISEPTIC MOUTHWASH bottle (reformulation) | 201303 | Medicine | A | 9/25/2012 | |
| LISTERINE TOTAL CARE ANTISEPTIC MOUTHWASH bottle | 178347 | Medicine | A | 12/13/2010 | |
| LISTERINE TOTAL CARE SENSITIVE ANTISEPTIC MOUTHWASH bottle | 178257 | Medicine | A | 12/9/2010 | |
| LISTERINE ANTISEPTIC MOUTHWASH oral liquid bottle | 60888 | Medicine | A | 8/21/1997 | |
| LISTERINE FRESHBURST ANTISEPTIC MOUTHWASH bottle (reformulation) | 201302 | Medicine | A | 9/25/2012 | |
| LISTERINE TARTAR CONTROL ANTISEPTIC MOUTHWASH bottle (reformulation) | 201304 | Medicine | A | 9/25/2012 | |
| LISTERINE TOTAL CARE SENSITIVE ANTISEPTIC MOUTHWASH | 315552 | Medicine | A | 3/19/2019 | |
| GOLD CROSS WHITFIELD'S ANTIFUNGAL OINTMENT jar | 14293 | Medicine | A | 8/30/1991 | |
| LISTERINE COOLMINT ANTISEPTIC MOUTHWASH bottle (reformulation) | 201301 | Medicine | A | 9/25/2012 | |
| LISTERINE TOTAL CARE SENSITIVE ANTIBACTERIAL MOUTHWASH bottle | 232749 | Medicine | A | 1/14/2015 |