Benzoic acid
- Generic Name
- Benzoic acid
- Brand Names
- Ammonul, Hyophen
- Drug Type
- Small Molecule
- Chemical Formula
- C7H6O2
- CAS Number
- 65-85-0
- Unique Ingredient Identifier
- 8SKN0B0MIM
Overview
A fungistatic compound that is widely used as a food preservative. It is conjugated to GLYCINE in the liver and excreted as hippuric acid. As the sodium salt form, sodium benzoate is used as a treatment for urea cycle disorders due to its ability to bind amino acids. This leads to excretion of these amino acids and a decrease in ammonia levels. Recent research shows that sodium benzoate may be beneficial as an add-on therapy (1 gram/day) in schizophrenia. Total Positive and Negative Syndrome Scale scores dropped by 21% compared to placebo.
Background
A fungistatic compound that is widely used as a food preservative. It is conjugated to GLYCINE in the liver and excreted as hippuric acid. As the sodium salt form, sodium benzoate is used as a treatment for urea cycle disorders due to its ability to bind amino acids. This leads to excretion of these amino acids and a decrease in ammonia levels. Recent research shows that sodium benzoate may be beneficial as an add-on therapy (1 gram/day) in schizophrenia. Total Positive and Negative Syndrome Scale scores dropped by 21% compared to placebo.
Indication
⑴与水杨酸合用于成龙皮肤真菌病、浅部真菌感染的体癣、手癣及足癣等，但目前有更多的高效抗真菌药，本制剂可作为二线治疗药。也用于食品和药物制剂的防腐剂，一般浓度为0.2％，或用0.5％的苯甲酸钠，溶解度更好。 ⑵用于罕见病精氨酸酶缺乏症的治疗。
Associated Conditions
- Fungal Infections
- Oropharyngeal pain
- Pain
- Ringworm
- Sore Throat
- Tinea Pedis
- Burning sensation in the mouth
- Dry cough
- Oral infections
- Throat infections
Clinical Trials
Title | Posted | Study ID | Phase | Status | Sponsor |
|---|
No clinical trials found
No clinical trials found for this drug
FDA Approved Products
Product Name | Manufacturer | Route | Strength | Approved | NDC Code |
|---|---|---|---|---|---|
ORAL | 9 mg in 1 1 | 2024/01/22 | 0178-0745 | ||
ORAL | 9 mg in 1 1 | 2017/01/05 | 0076-0901 |
EMA Approved Products
Medicine Name | EMA Number | Auth. Holder | Country | Drug Type | Status | Issued | Opinion | Revision |
|---|
No EMA products found
No EMA products found for this drug
HSA Approved Products
Product Name | Manufacturer | Dosage Form | Strength | Approved | Approval No. |
|---|---|---|---|---|---|
SOLUTION | 2% w/v | 1996/07/03 | SIN08773P | ||
OINTMENT | 6.01% w/w | 2022/07/07 | SIN16547P | ||
OINTMENT | 6% w/w | 1997/11/21 | SIN09544P | ||
OINTMENT | 6% w/w | 1998/06/18 | SIN09830P | ||
OINTMENT | 6.00% w/w | 1990/05/03 | SIN04418P |
NMPA Approved Products
Product Name | Approval No. | Manufacturer | Dosage Form | Trade Name | Strength | Type | Status | Date | Import |
|---|
No NMPA products found
No NMPA products found for this drug
PPB Approved Products
Product Name | Registration Code | Company | Category | Sale Type | Reg. Date |
|---|---|---|---|---|---|
HK-47300 | Non-Poison | OTC | 2001/01/29 | ||
HK-43177 | unicorn laboratories o/b american unicorn laboratories limited | Non-Poison | OTC | 1998/07/03 | |
HK-60544 | unicorn laboratories o/b american unicorn laboratories limited | Non-Poison | OTC | 2011/07/14 | |
HK-03692 | Non-Poison | OTC | 1979/01/24 | ||
HK-42813 | Non-Poison | OTC | 1998/02/11 | ||
HK-37305 | meyer pharmaceuticals ltd | Part 1, Schedule 1 & Schedule 3 Poison | POM | 1994/02/16 | |
HK-37310 | meyer pharmaceuticals ltd | Part 1, Schedule 1 & Schedule 3 Poison | POM | 1994/02/16 | |
HK-55912 | unicorn laboratories o/b american unicorn laboratories limited | Non-Poison | OTC | 2007/10/14 | |
HK-16008 | Non-Poison | OTC | 1981/09/19 | ||
HK-45385 | unicorn laboratories o/b american unicorn laboratories limited | Non-Poison | OTC | 1999/09/29 |
TGA Approved Products
Product Name | ARTG ID | Sponsor | Status | Reg. Date | Ingredient |
|---|---|---|---|---|---|
201303 | Active | 2012/09/25 | benzoic acid | ||
178347 | Active | 2010/12/13 | benzoic acid | ||
178257 | Active | 2010/12/09 | benzoic acid | ||
60888 | Active | 1997/08/21 | benzoic acid | ||
201302 | Active | 2012/09/25 | benzoic acid | ||
201304 | Active | 2012/09/25 | benzoic acid | ||
315552 | Active | 2019/03/19 | benzoic acid | ||
14293 | Active | 1991/08/30 | benzoic acid | ||
201301 | Active | 2012/09/25 | benzoic acid | ||
232749 | Active | 2015/01/14 | benzoic acid |