anti-thymocyte globulin
- Generic Name
- anti-thymocyte globulin
Gene-Edited Pig Kidney Functions in Macaque for Over Six Months in Chinese Study
• Chinese scientists achieved a breakthrough by maintaining a gene-edited pig kidney's function in a macaque for 184 days, marking progress in xenotransplantation.
• The pig kidney, modified with four gene edits, functioned normally for five months in the macaque before chronic rejection began.
• Researchers used an improved immunosuppressive regimen to extend graft survival, aiming to pave the way for human clinical trials.
• This milestone brings China closer to international standards in xenotransplantation research, addressing the critical need for organ donors.
Axatilimab Approved for Chronic GVHD After Failure of Two Prior Therapies
• Axatilimab has received FDA approval for treating chronic graft-versus-host disease (GVHD) in patients who have not responded to at least two prior systemic therapies.
• Chronic GVHD can affect almost any organ in the body, leading to significant symptom burden and long-term immunosuppression requirements for affected individuals.
• Current GVHD prevention methods, such as calcineurin inhibitors and methotrexate, have reduced incidence rates, but effective treatments are still needed for those affected.
• Emerging strategies like graft engineering with platforms such as Orca-T show promise in further reducing chronic GVHD rates, but the disease is unlikely to vanish completely.
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