Daprodustat
- Generic Name
- Daprodustat
- Brand Names
- Jesduvroq
- Drug Type
- Small Molecule
- Chemical Formula
- C19H27N3O6
- CAS Number
- 960539-70-2
- Unique Ingredient Identifier
- JVR38ZM64B
- Background
Daprodustat is a small-molecule hypoxia-inducible factor (HIF) prolyl hydroxylase (PHD) inhibitor that was developed by GSK. Patients with CKD cannot induce erythropoietin (EPO) production in response to hypoxia or anemia. As a potent inhibitor of PHD1, PHD2 and PHD3 (≥ 1000-fold selectivity), daprodustat stabilizes cellular HIF1α and HIF2α and the induces e...
- Indication
用于治疗由慢性肾脏病（CKD）导致的肾性贫血，包括透析和非透析CKD患者。
- Associated Conditions
- Anemia
- Associated Therapies
- -
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