Methylergometrine

Generic Name: Methylergometrine

Brand Names: Methergine

Drug Type: Small Molecule

Chemical Formula: C_₂₀H_₂₅N_₃O_₂

CAS Number: 113-42-8

Unique Ingredient Identifier: W53L6FE61V

Overview

A homolog of ergonovine containing one more CH2 group. (Merck Index, 11th ed)

Indication

For the prevention and control of excessive bleeding following vaginal childbirth

Associated Conditions

Angina Pectoris, Variant
Postpartum Haemorrhage (PPH)
Postpartum uterine subinvolution
Uterine Atony
Uterine Hemorrhage

Clinical Trials

Title	Posted	Study ID	Phase	Status	Sponsor
Prophylactic Methylergonovine for Twin Cesarean	2023/03/16	NCT05772156	Phase 4	Completed	Columbia University
Multimodal Uterotonics at the Time of Cesarean Section in Laboring Patients	2019/04/05	NCT03904446	Phase 4	Completed	Cynthia Wong
Second-Line Uterotonics in Postpartum Hemorrhage: A Randomized Clinical Trial	2018/07/12	NCT03584854	Phase 4	Active, not recruiting	Brigham and Women's Hospital
Intravenous Versus Intramuscular Administration of Methylergonovine for Uterine Contraction in Cesarean Sections	2017/10/05	NCT03303235	Early Phase 1	Withdrawn	Johns Hopkins University
Uterotonic Prophylaxis Trial	2015/04/06	NCT02408965	Phase 4	Completed	University of California, San Francisco
Reduction of Endometritis After Cesarean Section With the Routine Use of Methergine	2009/03/10	NCT00858832	Not Applicable	Completed	University of South Florida

FDA Drug Approvals

Approved Product	Manufacturer	NDC Code	Route	Strength	Effective Date
Methylergonovine Maleate	Amneal Pharmaceuticals NY LLC	69238-1605	ORAL	0.2 mg in 1 1	6/12/2025
Methergine	Dispensing Solutions, Inc.	66336-402	ORAL	0.2 mg in 1 1	9/22/2011
Methylergonovine Maleate	Rising Pharma Holdings, Inc.	16571-735	ORAL	0.2 mg in 1 1	11/24/2021
METHERGINE	Apotheca, Inc.	12634-179	ORAL	0.2 mg in 1 1	2/19/2010
METHYLERGONOVINE MALEATE	Breckenridge Pharmaceutical, Inc.	51991-144	INTRAVENOUS	0.2 mg in 1 mL	2/20/2024
Methylergonovine Maleate	Granules Pharmaceuticals Inc.	70010-786	ORAL	0.2 mg in 1 1	7/26/2023
Methylergonovine Maleate	ATLANTIC BIOLOGICALS CORP.	17856-3655	ORAL	0.2 mg in 1 1	1/31/2020
methylergonovine maleate	Pharmacist Pharmaceutical, LLC	63704-006	ORAL	0.2 mg in 1 1	5/26/2011
Methylergonovine Maleate	Novel Laboratories, Inc.	40032-140	ORAL	0.2 mg in 1 1	12/22/2017
Methylergonovine Maleate	Teva Pharmaceuticals USA, Inc.	0093-3655	ORAL	0.2 mg in 1 1	7/1/2018

EMA Drug Approvals

Approved Product	Authorization Holder	Status	Issued Date
No EMA approvals found for this drug.

HSA Drug Approvals

Approved Product	Manufacturer	Approval Number	Dosage Form	Strength	Approval Date
No HSA approvals found for this drug.

NMPA Drug Approvals

Approved Product	Company	Approval Number	Drug Type	Dosage Form	Approval Date
No NMPA approvals found for this drug.

PPB Drug Approvals

Approved Product	Registration No.	Company	Licence No.	Strength	Registration Date
No PPB approvals found for this drug.

TGA Drug Approvals

Approved Product	ARTG ID	Sponsor	Registration Type	Status	Registration Date
No TGA approvals found for this drug.

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