甲基麦角新碱 (Methergine)

概览

Methylergometrine is an ergot alkaloid used to prevent and control uterine atony and hemorrhage before and after delivery.

作用机制

Methylergometrine acts directly on the smooth muscle of the uterus and increases the tone, rate, and amplitude of rhythmic contractions through binding and the resultant antagonism of the dopamine D1 receptor. Thus, it induces a rapid and sustained tetanic uterotonic effect which shortens the third stage of labor and reduces blood loss.

适应症

For the prevention and control of excessive bleeding following vaginal childbirth

• Angina Pectoris, Variant
• Postpartum Haemorrhage (PPH)
• Postpartum uterine subinvolution
• Uterine Atony
• Uterine Hemorrhage