交沙霉素

概览

Josamycin is a macrolide antibiotic used for the treatment of various susceptible bacterial infections.

作用机制

The mechanism of action of macrolides such as Josamycin is via inhibition of bacterial protein biosynthesis by binding reversibly to the subunit 50S of the bacterial ribosome, thereby inhibiting translocation of peptidyl tRNA. This action is mainly bacteriostatic, but can also be bactericidal in high concentrations. Macrolides tend to accumulate within leukocytes, and are therefore actually transported into the site of infection.

适应症

For the treatment of bacterial infections.

• Bacterial Infections
• Biliary tract infection
• Breast Infection
• Dental and oral soft tissue infections
• Genital infection
• Respiratory Tract Infections (RTI)
• Soft Tissues Infections
• Ear, nose, and throat infections